Phosphoinositide-Dependent Signaling in Cancer: A Focus on Phospholipase C Isozymes
Phosphoinositides (PI) form just a minor portion of the total phospholipid content in cells but are significantly involved in cancer development and progression. In several cancer types, phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P ] and phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)...
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| Veröffentlicht in: | International journal of molecular sciences 2020-04, Vol.21 (7), p.2581 |
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| creator | Owusu Obeng, Eric Rusciano, Isabella Marvi, Maria Vittoria Fazio, Antonietta Ratti, Stefano Follo, Matilde Yung Xian, Jie Manzoli, Lucia Billi, Anna Maria Mongiorgi, Sara Ramazzotti, Giulia Cocco, Lucio |
| description | Phosphoinositides (PI) form just a minor portion of the total phospholipid content in cells but are significantly involved in cancer development and progression. In several cancer types, phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P
] and phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P
] play significant roles in regulating survival, proliferation, invasion, and growth of cancer cells. Phosphoinositide-specific phospholipase C (PLC) catalyze the generation of the essential second messengers diacylglycerol (DAG) and inositol 1,4,5 trisphosphate (InsP
) by hydrolyzing PtdIns(4,5)P
. DAG and InsP
regulate Protein Kinase C (PKC) activation and the release of calcium ions (Ca
) into the cytosol, respectively. This event leads to the control of several important biological processes implicated in cancer. PLCs have been extensively studied in cancer but their regulatory roles in the oncogenic process are not fully understood. This review aims to provide up-to-date knowledge on the involvement of PLCs in cancer. We focus specifically on PLCβ, PLCγ, PLCδ, and PLCε isoforms due to the numerous evidence of their involvement in various cancer types. |
| doi_str_mv | 10.3390/ijms21072581 |
| format | Article |
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] and phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P
] play significant roles in regulating survival, proliferation, invasion, and growth of cancer cells. Phosphoinositide-specific phospholipase C (PLC) catalyze the generation of the essential second messengers diacylglycerol (DAG) and inositol 1,4,5 trisphosphate (InsP
) by hydrolyzing PtdIns(4,5)P
. DAG and InsP
regulate Protein Kinase C (PKC) activation and the release of calcium ions (Ca
) into the cytosol, respectively. This event leads to the control of several important biological processes implicated in cancer. PLCs have been extensively studied in cancer but their regulatory roles in the oncogenic process are not fully understood. This review aims to provide up-to-date knowledge on the involvement of PLCs in cancer. We focus specifically on PLCβ, PLCγ, PLCδ, and PLCε isoforms due to the numerous evidence of their involvement in various cancer types.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms21072581</identifier><identifier>PMID: 32276377</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Animals ; Biological activity ; Breast cancer ; Calcium ; Calcium ions ; Cancer ; Cardiovascular system ; Cell adhesion & migration ; Cell growth ; Cell proliferation ; Cytosol ; Diglycerides ; Diglycerides - metabolism ; Enzymes ; Growth factors ; Humans ; Inositol 1,4,5-trisphosphate receptors ; Isoenzymes ; Isoforms ; Kinases ; Metabolism ; Neoplasms - enzymology ; Neoplasms - metabolism ; Neoplasms - physiopathology ; Phosphatidylinositol 3,4,5-triphosphate ; Phosphatidylinositol 4,5-diphosphate ; Phosphatidylinositols - metabolism ; Phosphoinositide Phospholipase C - metabolism ; Phosphoinositides ; Phospholipase ; Phospholipase C ; Phospholipids ; Phosphorylation ; Protein kinase C ; Protein Kinase C - metabolism ; Proteins ; Review ; Second messengers ; Signal Transduction</subject><ispartof>International journal of molecular sciences, 2020-04, Vol.21 (7), p.2581</ispartof><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c478t-2953b97c5eae0783ad67747bbfc49d693276cf1e605e1a1334026eb947715a373</citedby><cites>FETCH-LOGICAL-c478t-2953b97c5eae0783ad67747bbfc49d693276cf1e605e1a1334026eb947715a373</cites><orcidid>0000-0003-0403-9466 ; 0000-0001-9684-714X ; 0000-0002-3454-9072 ; 0000-0002-6258-5345</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177890/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177890/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32276377$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Owusu Obeng, Eric</creatorcontrib><creatorcontrib>Rusciano, Isabella</creatorcontrib><creatorcontrib>Marvi, Maria Vittoria</creatorcontrib><creatorcontrib>Fazio, Antonietta</creatorcontrib><creatorcontrib>Ratti, Stefano</creatorcontrib><creatorcontrib>Follo, Matilde Yung</creatorcontrib><creatorcontrib>Xian, Jie</creatorcontrib><creatorcontrib>Manzoli, Lucia</creatorcontrib><creatorcontrib>Billi, Anna Maria</creatorcontrib><creatorcontrib>Mongiorgi, Sara</creatorcontrib><creatorcontrib>Ramazzotti, Giulia</creatorcontrib><creatorcontrib>Cocco, Lucio</creatorcontrib><title>Phosphoinositide-Dependent Signaling in Cancer: A Focus on Phospholipase C Isozymes</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Phosphoinositides (PI) form just a minor portion of the total phospholipid content in cells but are significantly involved in cancer development and progression. In several cancer types, phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P
] and phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P
] play significant roles in regulating survival, proliferation, invasion, and growth of cancer cells. Phosphoinositide-specific phospholipase C (PLC) catalyze the generation of the essential second messengers diacylglycerol (DAG) and inositol 1,4,5 trisphosphate (InsP
) by hydrolyzing PtdIns(4,5)P
. DAG and InsP
regulate Protein Kinase C (PKC) activation and the release of calcium ions (Ca
) into the cytosol, respectively. This event leads to the control of several important biological processes implicated in cancer. PLCs have been extensively studied in cancer but their regulatory roles in the oncogenic process are not fully understood. This review aims to provide up-to-date knowledge on the involvement of PLCs in cancer. We focus specifically on PLCβ, PLCγ, PLCδ, and PLCε isoforms due to the numerous evidence of their involvement in various cancer types.</description><subject>Animals</subject><subject>Biological activity</subject><subject>Breast cancer</subject><subject>Calcium</subject><subject>Calcium ions</subject><subject>Cancer</subject><subject>Cardiovascular system</subject><subject>Cell adhesion & migration</subject><subject>Cell growth</subject><subject>Cell proliferation</subject><subject>Cytosol</subject><subject>Diglycerides</subject><subject>Diglycerides - metabolism</subject><subject>Enzymes</subject><subject>Growth factors</subject><subject>Humans</subject><subject>Inositol 1,4,5-trisphosphate receptors</subject><subject>Isoenzymes</subject><subject>Isoforms</subject><subject>Kinases</subject><subject>Metabolism</subject><subject>Neoplasms - enzymology</subject><subject>Neoplasms - metabolism</subject><subject>Neoplasms - physiopathology</subject><subject>Phosphatidylinositol 3,4,5-triphosphate</subject><subject>Phosphatidylinositol 4,5-diphosphate</subject><subject>Phosphatidylinositols - metabolism</subject><subject>Phosphoinositide Phospholipase C - metabolism</subject><subject>Phosphoinositides</subject><subject>Phospholipase</subject><subject>Phospholipase C</subject><subject>Phospholipids</subject><subject>Phosphorylation</subject><subject>Protein kinase C</subject><subject>Protein Kinase C - metabolism</subject><subject>Proteins</subject><subject>Review</subject><subject>Second messengers</subject><subject>Signal Transduction</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkctLxDAQxoMovm-eJeDFg9U82k7jQZD1CYKCeg5pOrubpU1qsxX0r7eLq6yeZmB-8_HNfIQccHYqpWJnbtZEwRmIrOBrZJunQiSM5bC-0m-RnRhnjAkpMrVJtqQQkEuAbfL8NA2xnQbnQ3RzV2FyhS36Cv2cPruJN7XzE-o8HRlvsTunl_Qm2D7S4OlytXatiUhH9D6Gz48G4x7ZGJs64v6y7pLXm-uX0V3y8Hh7P7p8SGwKxTwRKpOlApuhQQaFNFUOkEJZjm2qqlzJwaMdc8xZhtxwKVMmcixVCsAzI0Hukotv3bYvG6zs4LkztW4715juQwfj9N-Jd1M9Ce8aOECh2CBwvBTowluPca4bFy3WtfEY-qiFLIqCZ6D4gB79Q2eh74b3LCjFVZFDvnB08k3ZLsTY4fjXDGd6kZZeTWvAD1cP-IV_4pFfUseQLg</recordid><startdate>20200408</startdate><enddate>20200408</enddate><creator>Owusu Obeng, Eric</creator><creator>Rusciano, Isabella</creator><creator>Marvi, Maria Vittoria</creator><creator>Fazio, Antonietta</creator><creator>Ratti, Stefano</creator><creator>Follo, Matilde Yung</creator><creator>Xian, Jie</creator><creator>Manzoli, Lucia</creator><creator>Billi, Anna Maria</creator><creator>Mongiorgi, Sara</creator><creator>Ramazzotti, Giulia</creator><creator>Cocco, Lucio</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0403-9466</orcidid><orcidid>https://orcid.org/0000-0001-9684-714X</orcidid><orcidid>https://orcid.org/0000-0002-3454-9072</orcidid><orcidid>https://orcid.org/0000-0002-6258-5345</orcidid></search><sort><creationdate>20200408</creationdate><title>Phosphoinositide-Dependent Signaling in Cancer: A Focus on Phospholipase C Isozymes</title><author>Owusu Obeng, Eric ; Rusciano, Isabella ; Marvi, Maria Vittoria ; Fazio, Antonietta ; Ratti, Stefano ; Follo, Matilde Yung ; Xian, Jie ; Manzoli, Lucia ; Billi, Anna Maria ; Mongiorgi, Sara ; Ramazzotti, Giulia ; Cocco, Lucio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-2953b97c5eae0783ad67747bbfc49d693276cf1e605e1a1334026eb947715a373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Biological activity</topic><topic>Breast cancer</topic><topic>Calcium</topic><topic>Calcium ions</topic><topic>Cancer</topic><topic>Cardiovascular system</topic><topic>Cell adhesion & migration</topic><topic>Cell growth</topic><topic>Cell proliferation</topic><topic>Cytosol</topic><topic>Diglycerides</topic><topic>Diglycerides - metabolism</topic><topic>Enzymes</topic><topic>Growth factors</topic><topic>Humans</topic><topic>Inositol 1,4,5-trisphosphate receptors</topic><topic>Isoenzymes</topic><topic>Isoforms</topic><topic>Kinases</topic><topic>Metabolism</topic><topic>Neoplasms - enzymology</topic><topic>Neoplasms - metabolism</topic><topic>Neoplasms - physiopathology</topic><topic>Phosphatidylinositol 3,4,5-triphosphate</topic><topic>Phosphatidylinositol 4,5-diphosphate</topic><topic>Phosphatidylinositols - metabolism</topic><topic>Phosphoinositide Phospholipase C - metabolism</topic><topic>Phosphoinositides</topic><topic>Phospholipase</topic><topic>Phospholipase C</topic><topic>Phospholipids</topic><topic>Phosphorylation</topic><topic>Protein kinase C</topic><topic>Protein Kinase C - metabolism</topic><topic>Proteins</topic><topic>Review</topic><topic>Second messengers</topic><topic>Signal Transduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Owusu Obeng, Eric</creatorcontrib><creatorcontrib>Rusciano, Isabella</creatorcontrib><creatorcontrib>Marvi, Maria Vittoria</creatorcontrib><creatorcontrib>Fazio, Antonietta</creatorcontrib><creatorcontrib>Ratti, Stefano</creatorcontrib><creatorcontrib>Follo, Matilde Yung</creatorcontrib><creatorcontrib>Xian, Jie</creatorcontrib><creatorcontrib>Manzoli, Lucia</creatorcontrib><creatorcontrib>Billi, Anna Maria</creatorcontrib><creatorcontrib>Mongiorgi, Sara</creatorcontrib><creatorcontrib>Ramazzotti, Giulia</creatorcontrib><creatorcontrib>Cocco, Lucio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Owusu Obeng, Eric</au><au>Rusciano, Isabella</au><au>Marvi, Maria Vittoria</au><au>Fazio, Antonietta</au><au>Ratti, Stefano</au><au>Follo, Matilde Yung</au><au>Xian, Jie</au><au>Manzoli, Lucia</au><au>Billi, Anna Maria</au><au>Mongiorgi, Sara</au><au>Ramazzotti, Giulia</au><au>Cocco, Lucio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phosphoinositide-Dependent Signaling in Cancer: A Focus on Phospholipase C Isozymes</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2020-04-08</date><risdate>2020</risdate><volume>21</volume><issue>7</issue><spage>2581</spage><pages>2581-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>Phosphoinositides (PI) form just a minor portion of the total phospholipid content in cells but are significantly involved in cancer development and progression. In several cancer types, phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P
] and phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P
] play significant roles in regulating survival, proliferation, invasion, and growth of cancer cells. Phosphoinositide-specific phospholipase C (PLC) catalyze the generation of the essential second messengers diacylglycerol (DAG) and inositol 1,4,5 trisphosphate (InsP
) by hydrolyzing PtdIns(4,5)P
. DAG and InsP
regulate Protein Kinase C (PKC) activation and the release of calcium ions (Ca
) into the cytosol, respectively. This event leads to the control of several important biological processes implicated in cancer. PLCs have been extensively studied in cancer but their regulatory roles in the oncogenic process are not fully understood. This review aims to provide up-to-date knowledge on the involvement of PLCs in cancer. We focus specifically on PLCβ, PLCγ, PLCδ, and PLCε isoforms due to the numerous evidence of their involvement in various cancer types.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>32276377</pmid><doi>10.3390/ijms21072581</doi><orcidid>https://orcid.org/0000-0003-0403-9466</orcidid><orcidid>https://orcid.org/0000-0001-9684-714X</orcidid><orcidid>https://orcid.org/0000-0002-3454-9072</orcidid><orcidid>https://orcid.org/0000-0002-6258-5345</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | International journal of molecular sciences, 2020-04, Vol.21 (7), p.2581 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central |
| subjects | Animals Biological activity Breast cancer Calcium Calcium ions Cancer Cardiovascular system Cell adhesion & migration Cell growth Cell proliferation Cytosol Diglycerides Diglycerides - metabolism Enzymes Growth factors Humans Inositol 1,4,5-trisphosphate receptors Isoenzymes Isoforms Kinases Metabolism Neoplasms - enzymology Neoplasms - metabolism Neoplasms - physiopathology Phosphatidylinositol 3,4,5-triphosphate Phosphatidylinositol 4,5-diphosphate Phosphatidylinositols - metabolism Phosphoinositide Phospholipase C - metabolism Phosphoinositides Phospholipase Phospholipase C Phospholipids Phosphorylation Protein kinase C Protein Kinase C - metabolism Proteins Review Second messengers Signal Transduction |
| title | Phosphoinositide-Dependent Signaling in Cancer: A Focus on Phospholipase C Isozymes |
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