Apatinib Combined with Local Irradiation Leads to Systemic Tumor Control via Reversal of Immunosuppressive Tumor Microenvironment in Lung Cancer

Purpose This study aimed to investigate the potential systemic antitumor effects of stereotactic ablative radiotherapy (SABR) and apatinib (a novel vascular endothelial growth factor receptor 2 inhibitor) via reversing the immunosuppressive tumor microenvironment for lung carcinoma. Materials and Me...

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Veröffentlicht in:	Cancer research and treatment 2020, 52(2), , pp.406-418
Hauptverfasser:	Liang, Li-jun, Hu, Chen-xi, Wen, Yi-xuan, Geng, Xiao-wei, Chen, Ting, Gu, Guo-qing, Wang, Lei, Xia, You-you, Liu, Yong, Fei, Jia-yan, Dong, Jie, Zhao, Feng-hua, Ahongjiang, Yiliyar, Hui, Kai-yuan, Jiang, Xiao-dong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Combined Modality Therapy - methods Disease Models, Animal Female Humans Life Sciences & Biomedicine Lung Neoplasms - drug therapy Lung Neoplasms - radiotherapy Male Mice Mice, Inbred C57BL Oncology Original Protein Kinase Inhibitors - therapeutic use Pyridines - therapeutic use Science & Technology Tumor Microenvironment 의학일반
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