Coronary artery bypass grafting is associated with immunoparalysis of monocytes and dendritic cells

Coronary artery bypass grafting (CABG) triggers a systemic inflammatory response that may contribute to adverse outcomes. Dendritic cells (DC) and monocytes are immunoregulatory cells potentially affected by CABG, contributing to an altered immune state. This study investigated changes in DC and mon...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2020-04, Vol.24 (8), p.4791-4803
Hauptverfasser:	Perros, Alexis J., Esguerra‐Lallen, Arlanna, Rooks, Kelly, Chong, Fenny, Engkilde‐Pedersen, Sanne, Faddy, Helen M., Hewlett, Elise, Naidoo, Rishendran, Tung, John‐Paul, Fraser, John F., Tesar, Peter, Ziegenfuss, Marc, Smith, Susan, O’Brien, Donalee, Flower, Robert L., Dean, Melinda M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antigens Blood culture Bypass cardiac surgery Cardiovascular disease Cell Adhesion Molecules - genetics Cell culture Clinical outcomes Cloning Coronary artery coronary artery bypass Coronary Artery Bypass - adverse effects Coronary vessels Cytokines Dendritic cells Dendritic Cells - drug effects Dendritic Cells - immunology Female Fibrillation Flow cytometry Gene Expression Regulation - drug effects Heart surgery Hematology Hepatitis Histocompatibility antigen HLA HLA-DR Antigens - blood HLA-DR Antigens - genetics Homeostasis Humans immune modulation immunoparalysis Immunoregulation Infections Inflammation Interleukin-6 - blood Interleukin-6 - genetics Intracellular Leukocytes Lipopolysaccharides Lipopolysaccharides - pharmacology Male Monocytes Monocytes - drug effects Monocytes - immunology Neutrophils Original Paralysis - blood Paralysis - immunology Paralysis - pathology Patients Thoracic Surgery
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