Plasma Donors in the Southwestern United States Positively Contribute to the Diverse Therapeutic Antibody Profile of Immune Globulin Products
Human-plasma-derived immune globulin (IG) is used in augmentation therapy to provide protective levels of antibodies to patients with primary immune deficiency diseases (PIDD) and for prophylaxis against infectious diseases. To maintain the breadth of antibodies necessary for clinical protection, it...
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| Veröffentlicht in: | Scientific reports 2020-04, Vol.10 (1), p.6850, Article 6850 |
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| creator | Ciencewicki, Jonathan M. Schouest, Katherine R. Gierman, Todd M. Vandeberg, Peter J. Gooch, Barry D. |
| description | Human-plasma-derived immune globulin (IG) is used in augmentation therapy to provide protective levels of antibodies to patients with primary immune deficiency diseases (PIDD) and for prophylaxis against infectious diseases. To maintain the breadth of antibodies necessary for clinical protection, it is important to understand regional patterns of antibody seroprevalence in source plasma from which IG products are manufactured. In this study, source plasma from donation centers in various locations of the Southwestern quarter of the United States was surveyed for antibody titers to hepatitis A virus (HAV), measles virus (MeV), and cytomegalovirus (CMV). A broad range of anti-HAV Ig plasma titers was observed among these centers, with some centers exhibiting 3–5 times the titers of the others. Minor to no differences were observed for levels of anti-MeV and anti-CMV, respectively. Importantly, elevated anti-HAV Ig titers were broadly observed across plasma units obtained from the centers exhibiting high titers, indicative of a potential regional phenomenon among donors as opposed to few donors with singularly high titers. Plasma from these high-titer centers conferred significantly greater neutralization against HAV
in vitro
. The outcomes of this study give a glimpse of the antibody diversity inherent in human plasma used to manufacture IG products.. |
| doi_str_mv | 10.1038/s41598-020-63794-y |
| format | Article |
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in vitro
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in vitro
. The outcomes of this study give a glimpse of the antibody diversity inherent in human plasma used to manufacture IG products..</description><subject>13/1</subject><subject>631/250</subject><subject>631/250/251</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Antibodies, Viral - immunology</subject><subject>Blood Donors</subject><subject>Cell Line</subject><subject>Chlorocebus aethiops</subject><subject>Cytomegalovirus</subject><subject>Deficiency diseases</subject><subject>Female</subject><subject>Globulins</subject><subject>Hepatitis A</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Immunoglobulin G - immunology</subject><subject>Immunoglobulins</subject><subject>Immunoglobulins, Intravenous - immunology</subject><subject>Infectious diseases</subject><subject>Macaca mulatta</subject><subject>Male</subject><subject>multidisciplinary</subject><subject>Neutralization</subject><subject>Plasma</subject><subject>Prophylaxis</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Seroepidemiologic Studies</subject><subject>Serology</subject><subject>Southwestern United States - 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immunology</topic><topic>Blood Donors</topic><topic>Cell Line</topic><topic>Chlorocebus aethiops</topic><topic>Cytomegalovirus</topic><topic>Deficiency diseases</topic><topic>Female</topic><topic>Globulins</topic><topic>Hepatitis A</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Immunoglobulin G - immunology</topic><topic>Immunoglobulins</topic><topic>Immunoglobulins, Intravenous - immunology</topic><topic>Infectious diseases</topic><topic>Macaca mulatta</topic><topic>Male</topic><topic>multidisciplinary</topic><topic>Neutralization</topic><topic>Plasma</topic><topic>Prophylaxis</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Seroepidemiologic Studies</topic><topic>Serology</topic><topic>Southwestern United States - epidemiology</topic><topic>Virus Diseases - epidemiology</topic><topic>Virus Diseases - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ciencewicki, Jonathan M.</creatorcontrib><creatorcontrib>Schouest, Katherine R.</creatorcontrib><creatorcontrib>Gierman, Todd M.</creatorcontrib><creatorcontrib>Vandeberg, Peter J.</creatorcontrib><creatorcontrib>Gooch, Barry D.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ciencewicki, Jonathan M.</au><au>Schouest, Katherine R.</au><au>Gierman, Todd M.</au><au>Vandeberg, Peter J.</au><au>Gooch, Barry D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma Donors in the Southwestern United States Positively Contribute to the Diverse Therapeutic Antibody Profile of Immune Globulin Products</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2020-04-22</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>6850</spage><pages>6850-</pages><artnum>6850</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Human-plasma-derived immune globulin (IG) is used in augmentation therapy to provide protective levels of antibodies to patients with primary immune deficiency diseases (PIDD) and for prophylaxis against infectious diseases. To maintain the breadth of antibodies necessary for clinical protection, it is important to understand regional patterns of antibody seroprevalence in source plasma from which IG products are manufactured. In this study, source plasma from donation centers in various locations of the Southwestern quarter of the United States was surveyed for antibody titers to hepatitis A virus (HAV), measles virus (MeV), and cytomegalovirus (CMV). A broad range of anti-HAV Ig plasma titers was observed among these centers, with some centers exhibiting 3–5 times the titers of the others. Minor to no differences were observed for levels of anti-MeV and anti-CMV, respectively. Importantly, elevated anti-HAV Ig titers were broadly observed across plasma units obtained from the centers exhibiting high titers, indicative of a potential regional phenomenon among donors as opposed to few donors with singularly high titers. Plasma from these high-titer centers conferred significantly greater neutralization against HAV
in vitro
. The outcomes of this study give a glimpse of the antibody diversity inherent in human plasma used to manufacture IG products..</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32321978</pmid><doi>10.1038/s41598-020-63794-y</doi><orcidid>https://orcid.org/0000-0002-8840-6528</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 13/1 631/250 631/250/251 Animals Antibodies Antibodies, Viral - immunology Blood Donors Cell Line Chlorocebus aethiops Cytomegalovirus Deficiency diseases Female Globulins Hepatitis A Humanities and Social Sciences Humans Immunoglobulin G - immunology Immunoglobulins Immunoglobulins, Intravenous - immunology Infectious diseases Macaca mulatta Male multidisciplinary Neutralization Plasma Prophylaxis Science Science (multidisciplinary) Seroepidemiologic Studies Serology Southwestern United States - epidemiology Virus Diseases - epidemiology Virus Diseases - immunology |
| title | Plasma Donors in the Southwestern United States Positively Contribute to the Diverse Therapeutic Antibody Profile of Immune Globulin Products |
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