Rationale and Study Design of a Randomized Clinical Trial of Metformin to Prevent Frailty in Older Adults With Prediabetes

Abstract Background Frailty is a geriatric syndrome that leads to poor health outcomes with aging. Previous studies have demonstrated that insulin resistance and inflammation predict frailty onset. Metformin is a widely used, well-tolerated drug that improves insulin sensitivity and displays anti-in...

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Veröffentlicht in:	The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2020-01, Vol.75 (1), p.102-109
Hauptverfasser:	Espinoza, Sara E, Musi, Nicolas, Wang, Chen-pin, Michalek, Joel, Orsak, Beverly, Romo, Terry, Powers, Becky, Conde, Alice, Moris, Melody, Bair-Kelps, Darcy, Li, Yan, Ganapathy, Vinutha, Jergensen, Tyson E, Kelly, Lauri C, Jiwani, Rozmin
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aging Anti-inflammatory agents Antidiabetics Blood Glucose - metabolism Body composition Clinical trials Dementia disorders Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - drug therapy Double-Blind Method Dual energy X-ray absorptiometry Female Follow-Up Studies Frailty Frailty - blood Frailty - etiology Frailty - prevention & control Glucose Glucose tolerance Glucose Tolerance Test Humans Hypoglycemic Agents - administration & dosage Inflammation Insulin Insulin resistance Insulin Resistance - physiology Lung diseases Male Malignancy Metformin Metformin - administration & dosage Neurological diseases Older people Prognosis Skeletal muscle THE JOURNAL OF GERONTOLOGY: Translational Section: Drug Interventions Therapeutic applications Time Factors
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