Liposarcoma: molecular targets and therapeutic implications
Liposarcoma (LPS) is the most common soft tissue sarcoma and accounts for approximately 20 % of all adult sarcomas. Current treatment modalities (surgery, chemotherapy, and radiotherapy) all have limitations; therefore, molecularly driven studies are needed to improve the identification and increase...
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| Veröffentlicht in: | Cellular and molecular life sciences : CMLS 2016-10, Vol.73 (19), p.3711-3718 |
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| container_title | Cellular and molecular life sciences : CMLS |
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| creator | Bill, Kate Lynn J. Casadei, Lucia Prudner, Bethany C. Iwenofu, Hans Strohecker, Anne M. Pollock, Raphael E. |
| description | Liposarcoma (LPS) is the most common soft tissue sarcoma and accounts for approximately 20 % of all adult sarcomas. Current treatment modalities (surgery, chemotherapy, and radiotherapy) all have limitations; therefore, molecularly driven studies are needed to improve the identification and increased understanding of genetic and epigenetic deregulations in LPS if we are to successfully target specific tumorigenic drivers. It can be anticipated that such biology-driven therapeutics will improve treatments by selectively deleting cancer cells while sparing normal tissues. This review will focus on several therapeutically actionable molecular markers identified in well-differentiated LPS and dedifferentiated LPS, highlighting their potential clinical applicability. |
| doi_str_mv | 10.1007/s00018-016-2266-2 |
| format | Article |
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Current treatment modalities (surgery, chemotherapy, and radiotherapy) all have limitations; therefore, molecularly driven studies are needed to improve the identification and increased understanding of genetic and epigenetic deregulations in LPS if we are to successfully target specific tumorigenic drivers. It can be anticipated that such biology-driven therapeutics will improve treatments by selectively deleting cancer cells while sparing normal tissues. This review will focus on several therapeutically actionable molecular markers identified in well-differentiated LPS and dedifferentiated LPS, highlighting their potential clinical applicability.</description><identifier>ISSN: 1420-682X</identifier><identifier>EISSN: 1420-9071</identifier><identifier>DOI: 10.1007/s00018-016-2266-2</identifier><identifier>PMID: 27173057</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Animals ; Biochemistry ; Biomarkers, Tumor - metabolism ; Biomedical and Life Sciences ; Biomedicine ; Cancer ; Cell Biology ; Disease Progression ; Drug therapy ; Humans ; Life Sciences ; Liposarcoma - genetics ; Liposarcoma - pathology ; Liposarcoma - therapy ; MicroRNAs - genetics ; MicroRNAs - metabolism ; Molecular biology ; Molecular Targeted Therapy ; Review ; Sarcoma ; Tissues</subject><ispartof>Cellular and molecular life sciences : CMLS, 2016-10, Vol.73 (19), p.3711-3718</ispartof><rights>Springer International Publishing 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-5bb400318e64f6069f08cb04357cc3fc9f9b28d27a568f4b27109c10515aed293</citedby><cites>FETCH-LOGICAL-c503t-5bb400318e64f6069f08cb04357cc3fc9f9b28d27a568f4b27109c10515aed293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175098/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175098/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,313,314,727,780,784,792,885,27922,27924,27925,41488,42557,51319,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27173057$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bill, Kate Lynn J.</creatorcontrib><creatorcontrib>Casadei, Lucia</creatorcontrib><creatorcontrib>Prudner, Bethany C.</creatorcontrib><creatorcontrib>Iwenofu, Hans</creatorcontrib><creatorcontrib>Strohecker, Anne M.</creatorcontrib><creatorcontrib>Pollock, Raphael E.</creatorcontrib><title>Liposarcoma: molecular targets and therapeutic implications</title><title>Cellular and molecular life sciences : CMLS</title><addtitle>Cell. Mol. Life Sci</addtitle><addtitle>Cell Mol Life Sci</addtitle><description>Liposarcoma (LPS) is the most common soft tissue sarcoma and accounts for approximately 20 % of all adult sarcomas. Current treatment modalities (surgery, chemotherapy, and radiotherapy) all have limitations; therefore, molecularly driven studies are needed to improve the identification and increased understanding of genetic and epigenetic deregulations in LPS if we are to successfully target specific tumorigenic drivers. It can be anticipated that such biology-driven therapeutics will improve treatments by selectively deleting cancer cells while sparing normal tissues. This review will focus on several therapeutically actionable molecular markers identified in well-differentiated LPS and dedifferentiated LPS, highlighting their potential clinical applicability.</description><subject>Animals</subject><subject>Biochemistry</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer</subject><subject>Cell Biology</subject><subject>Disease Progression</subject><subject>Drug therapy</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Liposarcoma - genetics</subject><subject>Liposarcoma - pathology</subject><subject>Liposarcoma - therapy</subject><subject>MicroRNAs - genetics</subject><subject>MicroRNAs - metabolism</subject><subject>Molecular biology</subject><subject>Molecular Targeted Therapy</subject><subject>Review</subject><subject>Sarcoma</subject><subject>Tissues</subject><issn>1420-682X</issn><issn>1420-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkV1LwzAUhoMobk5_gDdS8Mab6knapKmCIMMvGHij4F1Is3TLaJuatIL_3szNMQXBm5zAec57Pl6EjjGcY4DswgMA5jFgFhPCwrODhjglEOeQ4d31n3HyOkAH3i8CTDlh-2hAMpwlQLMhupqY1nrplK3lZVTbSqu-ki7qpJvpzkeymUbdXDvZ6r4zKjJ1WxklO2Mbf4j2Sll5fbSOI_Ryd_s8fognT_eP45tJrCgkXUyLIgVIMNcsLRmwvASuCkgTmimVlCov84LwKckkZbxMizAc5AoDxVTqKcmTEbpe6bZ9Ueup0k3nZCVaZ2rpPoSVRvzMNGYuZvZdhC0p5DwInK0FnH3rte9EbbzSVSUbbXsvMMc5ToFnyX_QlKWUMBrQ01_owvauCZf4oshSDgcKryjlrPdOl5u5MYili2LlogguiqWLgoSak-2FNxXftgWArAAfUs1Mu63Wf6p-Ao7OpuQ</recordid><startdate>20161001</startdate><enddate>20161001</enddate><creator>Bill, Kate Lynn J.</creator><creator>Casadei, Lucia</creator><creator>Prudner, Bethany C.</creator><creator>Iwenofu, Hans</creator><creator>Strohecker, Anne M.</creator><creator>Pollock, Raphael E.</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SS</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20161001</creationdate><title>Liposarcoma: molecular targets and therapeutic implications</title><author>Bill, Kate Lynn J. ; Casadei, Lucia ; Prudner, Bethany C. ; Iwenofu, Hans ; Strohecker, Anne M. ; Pollock, Raphael E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-5bb400318e64f6069f08cb04357cc3fc9f9b28d27a568f4b27109c10515aed293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Biochemistry</topic><topic>Biomarkers, Tumor - 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Mol. Life Sci</stitle><addtitle>Cell Mol Life Sci</addtitle><date>2016-10-01</date><risdate>2016</risdate><volume>73</volume><issue>19</issue><spage>3711</spage><epage>3718</epage><pages>3711-3718</pages><issn>1420-682X</issn><eissn>1420-9071</eissn><abstract>Liposarcoma (LPS) is the most common soft tissue sarcoma and accounts for approximately 20 % of all adult sarcomas. Current treatment modalities (surgery, chemotherapy, and radiotherapy) all have limitations; therefore, molecularly driven studies are needed to improve the identification and increased understanding of genetic and epigenetic deregulations in LPS if we are to successfully target specific tumorigenic drivers. It can be anticipated that such biology-driven therapeutics will improve treatments by selectively deleting cancer cells while sparing normal tissues. This review will focus on several therapeutically actionable molecular markers identified in well-differentiated LPS and dedifferentiated LPS, highlighting their potential clinical applicability.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>27173057</pmid><doi>10.1007/s00018-016-2266-2</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1420-682X |
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| subjects | Animals Biochemistry Biomarkers, Tumor - metabolism Biomedical and Life Sciences Biomedicine Cancer Cell Biology Disease Progression Drug therapy Humans Life Sciences Liposarcoma - genetics Liposarcoma - pathology Liposarcoma - therapy MicroRNAs - genetics MicroRNAs - metabolism Molecular biology Molecular Targeted Therapy Review Sarcoma Tissues |
| title | Liposarcoma: molecular targets and therapeutic implications |
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