Opioid presynaptic disinhibition of the midbrain periaqueductal grey descending analgesic pathway

Background and Purpose The midbrain periaqueductal grey (PAG) plays a central role in modulating pain through a descending pathway that projects indirectly to the spinal cord via the rostroventral medial medulla (RVM). While opioids are potent analgesics that target the PAG, their cellular actions o...

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