Identification of tipifarnib sensitivity biomarkers in T-cell acute lymphoblastic leukemia and T-cell lymphoma

Patients diagnosed with T-cell leukemias and T-cell lymphomas (TCLs) still have a poor prognosis and an inadequate response to current therapies, highlighting the need for targeted treatments. We have analyzed the potential therapeutic value of the farnesyltransferase inhibitor, tipifarnib, in 25 TC...

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Veröffentlicht in:	Scientific reports 2020-04, Vol.10 (1), p.6721, Article 6721
Hauptverfasser:	Alonso-Alonso, Ruth, Mondéjar, Rufino, Martínez, Nerea, García-Diaz, Nuria, Pérez, Cristina, Merino, David, Rodríguez, Marta, Esteve-Codina, Anna, Fuste, Berta, Gut, Marta, Burrows, Francis, Scholz, Catherine, Vaqué, Jose Pedro, Gualberto, Antonio, Piris, Miguel Ángel
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208 631/337 631/67 631/67/1990 631/67/68 631/67/69 692/4017 692/4028 692/53 Acute lymphoblastic leukemia Apoptosis Apoptosis - drug effects Biomarkers Biomarkers, Tumor - metabolism Cell cycle Cell Cycle - drug effects Cell Line, Tumor Cell Survival - drug effects Cell viability Down-Regulation - drug effects Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics Farnesyltransferase Gene Expression Regulation, Leukemic - drug effects Genomics Humanities and Social Sciences Humans Immunohistochemistry Inhibitory Concentration 50 Leukemia Lymphatic leukemia Lymphocytes T Lymphoma Lymphoma, T-Cell - drug therapy Lymphoma, T-Cell - genetics Lymphoma, T-Cell - pathology Mitochondria multidisciplinary Mutation - genetics Notch1 protein p53 Protein Phenotype Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - pathology Quinolones - pharmacology Quinolones - therapeutic use RelB protein Ribonucleic acid RNA Science Science (multidisciplinary) Signal Transduction - drug effects T-cell lymphoma T-Lymphocytes - drug effects T-Lymphocytes - immunology Tumor cell lines
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