Hepatitis B: changes in epidemiological features of Afro-descendant communities in Central Brazil
Hepatitis B virus (HBV) infection is still a concern in vulnerable populations. In a study performed by our team in 1999–2003 in two Afro-Brazilian communities, Furnas dos Dionísios (FD) and São Benedito (SB), high prevalence rates of HBV exposure (42.7% and 16.0%, respectively), high susceptibility...
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| creator | Lima, Livia Alves Lago, Bárbara Vieira do Weis-Torres, Sabrina Moreira dos Santos Martins, Regina Maria Bringel Cesar, Gabriela Alves Bandeira, Larissa Melo Rezende, Grazielli Rocha Lindenberg, Andrea de Siqueira Campos Gomes, Selma Andrade Motta-Castro, Ana Rita Coimbra |
| description | Hepatitis B virus (HBV) infection is still a concern in vulnerable populations. In a study performed by our team in 1999–2003 in two Afro-Brazilian communities, Furnas dos Dionísios (FD) and São Benedito (SB), high prevalence rates of HBV exposure (42.7% and 16.0%, respectively), high susceptibility to HBV (55.3% and 63.0%) and low HBV vaccination like profile rates (2.0% and 21.0%) were observed. In 2015–2016, we reassessed HBV epidemiological and molecular features in these two communities to verify the impact of health actions adopted in the last years. The prevalence rate of HBV exposure among the enrolled 331 subjects was 35.3% in FD and 21.8% in SB. HBV chronic infection (5.8% in FD, 4.9% in SB) remained high. The rate of HBV vaccination like profile increased from 10.7% to 43.5% (2.0% to 45.9% in FD, 21.0% to 39.5% in SB) while susceptible subjects declined from 58.9% to 26.3% (55.3% to 18.8% in FD, 63.0% to 38.7% in SB). Among 18 HBsAg positive samples, 13 were successfully sequenced (pre-S/S region). Phylogenetic analyses showed that all isolates belong to HBV subgenotype A1, clustering within the Asian-American clade. Despite the maintenance of high prevalence rate of HBV exposure over these 13 years of surveillance, significant improvements were observed, reinforcing the importance of facilitated HBV vaccination to difficult-to-access population to close gaps in prevention. |
| doi_str_mv | 10.1038/s41598-020-63094-5 |
| format | Article |
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In a study performed by our team in 1999–2003 in two Afro-Brazilian communities, Furnas dos Dionísios (FD) and São Benedito (SB), high prevalence rates of HBV exposure (42.7% and 16.0%, respectively), high susceptibility to HBV (55.3% and 63.0%) and low HBV vaccination like profile rates (2.0% and 21.0%) were observed. In 2015–2016, we reassessed HBV epidemiological and molecular features in these two communities to verify the impact of health actions adopted in the last years. The prevalence rate of HBV exposure among the enrolled 331 subjects was 35.3% in FD and 21.8% in SB. HBV chronic infection (5.8% in FD, 4.9% in SB) remained high. The rate of HBV vaccination like profile increased from 10.7% to 43.5% (2.0% to 45.9% in FD, 21.0% to 39.5% in SB) while susceptible subjects declined from 58.9% to 26.3% (55.3% to 18.8% in FD, 63.0% to 38.7% in SB). Among 18 HBsAg positive samples, 13 were successfully sequenced (pre-S/S region). Phylogenetic analyses showed that all isolates belong to HBV subgenotype A1, clustering within the Asian-American clade. Despite the maintenance of high prevalence rate of HBV exposure over these 13 years of surveillance, significant improvements were observed, reinforcing the importance of facilitated HBV vaccination to difficult-to-access population to close gaps in prevention.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-63094-5</identifier><identifier>PMID: 32317697</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>13 ; 13/51 ; 45 ; 45/22 ; 45/23 ; 45/29 ; 631/326/2521 ; 692/4020/4021 ; 692/499 ; Adolescent ; Adult ; African Continental Ancestry Group ; Asian Americans ; Behavior ; Biomarkers - blood ; Brazil - epidemiology ; Child ; Child, Preschool ; Chronic infection ; Demography ; Epidemiology ; Female ; Hepatitis ; Hepatitis B ; Hepatitis B - blood ; Hepatitis B - epidemiology ; Hepatitis B - immunology ; Hepatitis B surface antigen ; Hepatitis B virus - genetics ; Hepatitis B virus - physiology ; Humanities and Social Sciences ; Humans ; Immunization ; Infant ; Male ; Middle Aged ; multidisciplinary ; Phylogeny ; Population studies ; Prevalence ; Science ; Science (multidisciplinary) ; Vaccination ; Young Adult</subject><ispartof>Scientific reports, 2020-04, Vol.10 (1), p.6708-6708, Article 6708</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c522t-946c8b4167c87bb2239918037e8eede4f98f130fffd6f41836d7f3526d4224593</citedby><cites>FETCH-LOGICAL-c522t-946c8b4167c87bb2239918037e8eede4f98f130fffd6f41836d7f3526d4224593</cites><orcidid>0000-0002-3457-1675 ; 0000-0002-9173-6309</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174315/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174315/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32317697$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lima, Livia Alves</creatorcontrib><creatorcontrib>Lago, Bárbara Vieira do</creatorcontrib><creatorcontrib>Weis-Torres, Sabrina Moreira dos Santos</creatorcontrib><creatorcontrib>Martins, Regina Maria Bringel</creatorcontrib><creatorcontrib>Cesar, Gabriela Alves</creatorcontrib><creatorcontrib>Bandeira, Larissa Melo</creatorcontrib><creatorcontrib>Rezende, Grazielli Rocha</creatorcontrib><creatorcontrib>Lindenberg, Andrea de Siqueira Campos</creatorcontrib><creatorcontrib>Gomes, Selma Andrade</creatorcontrib><creatorcontrib>Motta-Castro, Ana Rita Coimbra</creatorcontrib><title>Hepatitis B: changes in epidemiological features of Afro-descendant communities in Central Brazil</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Hepatitis B virus (HBV) infection is still a concern in vulnerable populations. In a study performed by our team in 1999–2003 in two Afro-Brazilian communities, Furnas dos Dionísios (FD) and São Benedito (SB), high prevalence rates of HBV exposure (42.7% and 16.0%, respectively), high susceptibility to HBV (55.3% and 63.0%) and low HBV vaccination like profile rates (2.0% and 21.0%) were observed. In 2015–2016, we reassessed HBV epidemiological and molecular features in these two communities to verify the impact of health actions adopted in the last years. The prevalence rate of HBV exposure among the enrolled 331 subjects was 35.3% in FD and 21.8% in SB. HBV chronic infection (5.8% in FD, 4.9% in SB) remained high. The rate of HBV vaccination like profile increased from 10.7% to 43.5% (2.0% to 45.9% in FD, 21.0% to 39.5% in SB) while susceptible subjects declined from 58.9% to 26.3% (55.3% to 18.8% in FD, 63.0% to 38.7% in SB). Among 18 HBsAg positive samples, 13 were successfully sequenced (pre-S/S region). Phylogenetic analyses showed that all isolates belong to HBV subgenotype A1, clustering within the Asian-American clade. 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In a study performed by our team in 1999–2003 in two Afro-Brazilian communities, Furnas dos Dionísios (FD) and São Benedito (SB), high prevalence rates of HBV exposure (42.7% and 16.0%, respectively), high susceptibility to HBV (55.3% and 63.0%) and low HBV vaccination like profile rates (2.0% and 21.0%) were observed. In 2015–2016, we reassessed HBV epidemiological and molecular features in these two communities to verify the impact of health actions adopted in the last years. The prevalence rate of HBV exposure among the enrolled 331 subjects was 35.3% in FD and 21.8% in SB. HBV chronic infection (5.8% in FD, 4.9% in SB) remained high. The rate of HBV vaccination like profile increased from 10.7% to 43.5% (2.0% to 45.9% in FD, 21.0% to 39.5% in SB) while susceptible subjects declined from 58.9% to 26.3% (55.3% to 18.8% in FD, 63.0% to 38.7% in SB). Among 18 HBsAg positive samples, 13 were successfully sequenced (pre-S/S region). Phylogenetic analyses showed that all isolates belong to HBV subgenotype A1, clustering within the Asian-American clade. Despite the maintenance of high prevalence rate of HBV exposure over these 13 years of surveillance, significant improvements were observed, reinforcing the importance of facilitated HBV vaccination to difficult-to-access population to close gaps in prevention.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32317697</pmid><doi>10.1038/s41598-020-63094-5</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-3457-1675</orcidid><orcidid>https://orcid.org/0000-0002-9173-6309</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 13 13/51 45 45/22 45/23 45/29 631/326/2521 692/4020/4021 692/499 Adolescent Adult African Continental Ancestry Group Asian Americans Behavior Biomarkers - blood Brazil - epidemiology Child Child, Preschool Chronic infection Demography Epidemiology Female Hepatitis Hepatitis B Hepatitis B - blood Hepatitis B - epidemiology Hepatitis B - immunology Hepatitis B surface antigen Hepatitis B virus - genetics Hepatitis B virus - physiology Humanities and Social Sciences Humans Immunization Infant Male Middle Aged multidisciplinary Phylogeny Population studies Prevalence Science Science (multidisciplinary) Vaccination Young Adult |
| title | Hepatitis B: changes in epidemiological features of Afro-descendant communities in Central Brazil |
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