Evasion of early innate immune response by 2′- O -methylation of dengue genomic RNA

Abstract Dengue virus (DENV) is the most prevalent mosquito-borne virus pathogen in humans. There is currently no antiviral therapeutic or widely available vaccine against dengue infection. The DENV RNA genome is methylated on its 5′ cap by its NS5 protein. DENV bearing a single E216A point mutation...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2016-12, Vol.499, p.259-266
Hauptverfasser:	Chang, David C, Hoang, Long T, Mohamed Naim, Ahmad Nazri, Dong, Hongping, Schreiber, Mark J, Hibberd, Martin L, Tan, Min Jie Alvin, Shi, Pei-Yong
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line Dengue - immunology Dengue - virology Dengue virus Dengue Virus - chemistry Dengue Virus - genetics Dengue Virus - immunology DNA Methylation Genomics Humans Immune Evasion Immunity, Innate Infectious Disease Innate immune response Methyltransferase NS5 RNA, Viral - chemistry RNA, Viral - genetics RNA, Viral - immunology
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