Identification of Risk Loci for Parkinson Disease in Asians and Comparison of Risk Between Asians and Europeans: A Genome-Wide Association Study

IMPORTANCE: Large-scale genome-wide association studies in the European population have identified 90 risk variants associated with Parkinson disease (PD); however, there are limited studies in the largest population worldwide (ie, Asian). OBJECTIVES: To identify novel genome-wide significant loci f...

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Veröffentlicht in:	Archives of neurology (Chicago) 2020-06, Vol.77 (6), p.746-754
Hauptverfasser:	Foo, Jia Nee, Chew, Elaine Guo Yan, Chung, Sun Ju, Peng, Rong, Blauwendraat, Cornelis, Nalls, Mike A, Mok, Kin Y, Satake, Wataru, Toda, Tatsushi, Chao, Yinxia, Tan, Louis C. S, Tandiono, Moses, Lian, Michelle M, Ng, Ebonne Y, Prakash, Kumar-M, Au, Wing-Lok, Meah, Wee-Yang, Mok, Shi Qi, Annuar, Azlina Ahmad, Chan, Anne Y. Y, Chen, Ling, Chen, Yongping, Jeon, Beom S, Jiang, Lulu, Lim, Jia Lun, Lin, Juei-Jueng, Liu, Chunfeng, Mao, Chengjie, Mok, Vincent, Pei, Zhong, Shang, Hui-Fang, Shi, Chang-He, Song, Kyuyoung, Tan, Ai Huey, Wu, Yih-Ru, Xu, Yu-ming, Xu, Renshi, Yan, Yaping, Yang, Jing, Zhang, BaoRong, Koh, Woon-Puay, Lim, Shen-Yang, Khor, Chiea Chuen, Liu, Jianjun, Tan, Eng-King
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aged Asian people Asian People - genetics Comments Female Gene loci Genetic Predisposition to Disease - genetics Genome-wide association studies Genome-Wide Association Study Genomes Genotype Genotypes Health risks Heterogeneity Humans Male Membrane Glycoproteins - genetics Middle Aged Movement disorders N-Acetylgalactosaminyltransferases - genetics Nerve Tissue Proteins - genetics Neurodegenerative diseases Online First Original Investigation Parkinson Disease - genetics Parkinson's disease Polypeptide N-acetylgalactosaminyltransferase Population Population studies Precision medicine Quality control Replication Risk analysis Risk Factors Risk management Systematic review Variance analysis White People - genetics
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