A time‐saving–modified Giemsa stain is a better diagnostic method of Helicobacter pylori infection compared with the rapid urease test
Background Despite having chronic gastritis, most people infected by Helicobacter pylori (H. pylori) are asymptomatic and have no specific clinical signs and symptoms. H. pylori infection can be diagnosed by several detection methods. Giemsa stain and rapid urease test (CLO test) are the most perfor...
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| Veröffentlicht in: | Journal of clinical laboratory analysis 2020-04, Vol.34 (4), p.e23110-n/a |
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| description | Background
Despite having chronic gastritis, most people infected by Helicobacter pylori (H. pylori) are asymptomatic and have no specific clinical signs and symptoms. H. pylori infection can be diagnosed by several detection methods. Giemsa stain and rapid urease test (CLO test) are the most performed tests of H. pylori infection at first‐line clinical examination because of their simplicity and reliability. However, the sensitivity of CLO test is significantly reduced in patients with atrophic gastritis and intestinal metaplasia, and the weaknesses of Giemsa stain are higher cost and time‐consuming.
Methods
The Giemsa stain was modified in several staining solutions and procedures based on the simplified Giemsa technique described by Gray, Wyatt, & Rathbone (1986). The modified Giemsa stain is examined its efficacy and compared with the CLO test using 233 H. pylori‐infected patients with gastric disease.
Results
The modified Giemsa stain is comparable to the traditional one. Statistical analysis indicated that the modified Giemsa stain obtains greater accuracy in H. pylori‐infected patients with gastritis and ulcer than the CLO test (48.1% vs. 43.7%). Moreover, considering the prognosis of different symptoms of gastric diseases, the modified Giemsa stain has a more accurate prognosis than combination symptoms (P = 1.8E‐05 vs. P = 5.49E‐05). The modified Giemsa stain is confirmed to be better than CLO test using 233 H. pylori‐infected patients with gastric disease.
Conclusions
The modified Giemsa stain is more simplified and time‐saving than traditional Giemsa stain, which is comparable to the traditional one and is confirmed to be better than CLO test using 233 H. pylori‐infected patients with gastric disease. In clinical examination, this modified Giemsa stain can be applied to routine examination and provides quick and accurate diagnosis and prognosis to H. pylori‐infected patients with gastric diseases. |
| doi_str_mv | 10.1002/jcla.23110 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7171334</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2392152839</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4480-cbed252c76ad0ace3f770056dcea13d4a5fd6e61cf0aae96184aeb7de97671523</originalsourceid><addsrcrecordid>eNp9kTFv1DAYhi0Eokdh4QcgSywIKcWOkzhZkE4n2oJOYoHZ-mJ_ufMpiYPttLqtMxNS_2F_CT6uVMDA5MGPH73WQ8hLzs44Y_m7ne7hLBecs0dkwVlTZ3mdl4_JgtW1zGrGxQl5FsKOMVY3vHpKTgSXQjAmF-T7kkY74N3NjwBXdtzc3dwOztjOoqEXFocANESwI7WBAm0xRvTUWNiMLkSr6YBx6wx1Hb3E3mrXgj4Q07533lI7dqijdSPVbpjAJ-m1jVsat0g9TNbQ2SMEpBFDfE6edNAHfHF_npKv5x--rC6z9eeLj6vlOtNFUbNMt2jyMteyAsNAo-ikZKysjEbgwhRQdqbCiuuOAWBT8boAbKXBRlaSl7k4Je-P3mluB0zPxuihV5O3A_i9cmDV3zej3aqNu1KSSy5EkQRv7gXefZvTcjXYoLHvYUQ3B5VSlJxVVcMT-vofdOdmP6bvJarJ05xaNIl6e6S0dyF47B7GcKYOidUhsfqVOMGv_pz_gP5umgB-BK5tj_v_qNSn1Xp5lP4EIKm2kg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2392152839</pqid></control><display><type>article</type><title>A time‐saving–modified Giemsa stain is a better diagnostic method of Helicobacter pylori infection compared with the rapid urease test</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Access via Wiley Online Library</source><source>Wiley Online Library Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Fan, Chi‐Chen ; Chen, Chung‐Hsing ; Chou, Chi ; Kao, Ting‐Yu ; Cheng, An Ning ; Lee, Alan Yueh‐Luen ; Kuo, Cheng‐Liang</creator><creatorcontrib>Fan, Chi‐Chen ; Chen, Chung‐Hsing ; Chou, Chi ; Kao, Ting‐Yu ; Cheng, An Ning ; Lee, Alan Yueh‐Luen ; Kuo, Cheng‐Liang</creatorcontrib><description>Background
Despite having chronic gastritis, most people infected by Helicobacter pylori (H. pylori) are asymptomatic and have no specific clinical signs and symptoms. H. pylori infection can be diagnosed by several detection methods. Giemsa stain and rapid urease test (CLO test) are the most performed tests of H. pylori infection at first‐line clinical examination because of their simplicity and reliability. However, the sensitivity of CLO test is significantly reduced in patients with atrophic gastritis and intestinal metaplasia, and the weaknesses of Giemsa stain are higher cost and time‐consuming.
Methods
The Giemsa stain was modified in several staining solutions and procedures based on the simplified Giemsa technique described by Gray, Wyatt, & Rathbone (1986). The modified Giemsa stain is examined its efficacy and compared with the CLO test using 233 H. pylori‐infected patients with gastric disease.
Results
The modified Giemsa stain is comparable to the traditional one. Statistical analysis indicated that the modified Giemsa stain obtains greater accuracy in H. pylori‐infected patients with gastritis and ulcer than the CLO test (48.1% vs. 43.7%). Moreover, considering the prognosis of different symptoms of gastric diseases, the modified Giemsa stain has a more accurate prognosis than combination symptoms (P = 1.8E‐05 vs. P = 5.49E‐05). The modified Giemsa stain is confirmed to be better than CLO test using 233 H. pylori‐infected patients with gastric disease.
Conclusions
The modified Giemsa stain is more simplified and time‐saving than traditional Giemsa stain, which is comparable to the traditional one and is confirmed to be better than CLO test using 233 H. pylori‐infected patients with gastric disease. In clinical examination, this modified Giemsa stain can be applied to routine examination and provides quick and accurate diagnosis and prognosis to H. pylori‐infected patients with gastric diseases.</description><identifier>ISSN: 0887-8013</identifier><identifier>EISSN: 1098-2825</identifier><identifier>DOI: 10.1002/jcla.23110</identifier><identifier>PMID: 31733007</identifier><language>eng</language><publisher>United States: John Wiley & Sons, Inc</publisher><subject>Accuracy ; Azure Stains ; Biopsy ; Chronic infection ; Endoscopy ; gastric diseases ; Gastritis ; Gastritis - microbiology ; H. pylori ; Helicobacter Infections - diagnosis ; Helicobacter Infections - pathology ; Helicobacter pylori ; histological techniques ; Humans ; Hyperplasia ; Infections ; Intestine ; Medical prognosis ; Metaplasia ; Methods ; new Giemsa stain ; Patients ; Prognosis ; Sensitivity analysis ; Stains & staining ; Statistical analysis ; Stomach Ulcer - microbiology ; Ulcers ; Urease ; Urease - metabolism</subject><ispartof>Journal of clinical laboratory analysis, 2020-04, Vol.34 (4), p.e23110-n/a</ispartof><rights>2019 The Authors. published by Wiley Periodicals, Inc.</rights><rights>2019 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals, Inc.</rights><rights>2020. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4480-cbed252c76ad0ace3f770056dcea13d4a5fd6e61cf0aae96184aeb7de97671523</citedby><cites>FETCH-LOGICAL-c4480-cbed252c76ad0ace3f770056dcea13d4a5fd6e61cf0aae96184aeb7de97671523</cites><orcidid>0000-0001-7145-1878 ; 0000-0003-0252-0571 ; 0000-0003-2401-9390</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171334/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171334/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,1417,11562,27924,27925,45574,45575,46052,46476,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31733007$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fan, Chi‐Chen</creatorcontrib><creatorcontrib>Chen, Chung‐Hsing</creatorcontrib><creatorcontrib>Chou, Chi</creatorcontrib><creatorcontrib>Kao, Ting‐Yu</creatorcontrib><creatorcontrib>Cheng, An Ning</creatorcontrib><creatorcontrib>Lee, Alan Yueh‐Luen</creatorcontrib><creatorcontrib>Kuo, Cheng‐Liang</creatorcontrib><title>A time‐saving–modified Giemsa stain is a better diagnostic method of Helicobacter pylori infection compared with the rapid urease test</title><title>Journal of clinical laboratory analysis</title><addtitle>J Clin Lab Anal</addtitle><description>Background
Despite having chronic gastritis, most people infected by Helicobacter pylori (H. pylori) are asymptomatic and have no specific clinical signs and symptoms. H. pylori infection can be diagnosed by several detection methods. Giemsa stain and rapid urease test (CLO test) are the most performed tests of H. pylori infection at first‐line clinical examination because of their simplicity and reliability. However, the sensitivity of CLO test is significantly reduced in patients with atrophic gastritis and intestinal metaplasia, and the weaknesses of Giemsa stain are higher cost and time‐consuming.
Methods
The Giemsa stain was modified in several staining solutions and procedures based on the simplified Giemsa technique described by Gray, Wyatt, & Rathbone (1986). The modified Giemsa stain is examined its efficacy and compared with the CLO test using 233 H. pylori‐infected patients with gastric disease.
Results
The modified Giemsa stain is comparable to the traditional one. Statistical analysis indicated that the modified Giemsa stain obtains greater accuracy in H. pylori‐infected patients with gastritis and ulcer than the CLO test (48.1% vs. 43.7%). Moreover, considering the prognosis of different symptoms of gastric diseases, the modified Giemsa stain has a more accurate prognosis than combination symptoms (P = 1.8E‐05 vs. P = 5.49E‐05). The modified Giemsa stain is confirmed to be better than CLO test using 233 H. pylori‐infected patients with gastric disease.
Conclusions
The modified Giemsa stain is more simplified and time‐saving than traditional Giemsa stain, which is comparable to the traditional one and is confirmed to be better than CLO test using 233 H. pylori‐infected patients with gastric disease. In clinical examination, this modified Giemsa stain can be applied to routine examination and provides quick and accurate diagnosis and prognosis to H. pylori‐infected patients with gastric diseases.</description><subject>Accuracy</subject><subject>Azure Stains</subject><subject>Biopsy</subject><subject>Chronic infection</subject><subject>Endoscopy</subject><subject>gastric diseases</subject><subject>Gastritis</subject><subject>Gastritis - microbiology</subject><subject>H. pylori</subject><subject>Helicobacter Infections - diagnosis</subject><subject>Helicobacter Infections - pathology</subject><subject>Helicobacter pylori</subject><subject>histological techniques</subject><subject>Humans</subject><subject>Hyperplasia</subject><subject>Infections</subject><subject>Intestine</subject><subject>Medical prognosis</subject><subject>Metaplasia</subject><subject>Methods</subject><subject>new Giemsa stain</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Sensitivity analysis</subject><subject>Stains & staining</subject><subject>Statistical analysis</subject><subject>Stomach Ulcer - microbiology</subject><subject>Ulcers</subject><subject>Urease</subject><subject>Urease - metabolism</subject><issn>0887-8013</issn><issn>1098-2825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kTFv1DAYhi0Eokdh4QcgSywIKcWOkzhZkE4n2oJOYoHZ-mJ_ufMpiYPttLqtMxNS_2F_CT6uVMDA5MGPH73WQ8hLzs44Y_m7ne7hLBecs0dkwVlTZ3mdl4_JgtW1zGrGxQl5FsKOMVY3vHpKTgSXQjAmF-T7kkY74N3NjwBXdtzc3dwOztjOoqEXFocANESwI7WBAm0xRvTUWNiMLkSr6YBx6wx1Hb3E3mrXgj4Q07533lI7dqijdSPVbpjAJ-m1jVsat0g9TNbQ2SMEpBFDfE6edNAHfHF_npKv5x--rC6z9eeLj6vlOtNFUbNMt2jyMteyAsNAo-ikZKysjEbgwhRQdqbCiuuOAWBT8boAbKXBRlaSl7k4Je-P3mluB0zPxuihV5O3A_i9cmDV3zej3aqNu1KSSy5EkQRv7gXefZvTcjXYoLHvYUQ3B5VSlJxVVcMT-vofdOdmP6bvJarJ05xaNIl6e6S0dyF47B7GcKYOidUhsfqVOMGv_pz_gP5umgB-BK5tj_v_qNSn1Xp5lP4EIKm2kg</recordid><startdate>202004</startdate><enddate>202004</enddate><creator>Fan, Chi‐Chen</creator><creator>Chen, Chung‐Hsing</creator><creator>Chou, Chi</creator><creator>Kao, Ting‐Yu</creator><creator>Cheng, An Ning</creator><creator>Lee, Alan Yueh‐Luen</creator><creator>Kuo, Cheng‐Liang</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7145-1878</orcidid><orcidid>https://orcid.org/0000-0003-0252-0571</orcidid><orcidid>https://orcid.org/0000-0003-2401-9390</orcidid></search><sort><creationdate>202004</creationdate><title>A time‐saving–modified Giemsa stain is a better diagnostic method of Helicobacter pylori infection compared with the rapid urease test</title><author>Fan, Chi‐Chen ; Chen, Chung‐Hsing ; Chou, Chi ; Kao, Ting‐Yu ; Cheng, An Ning ; Lee, Alan Yueh‐Luen ; Kuo, Cheng‐Liang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4480-cbed252c76ad0ace3f770056dcea13d4a5fd6e61cf0aae96184aeb7de97671523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Accuracy</topic><topic>Azure Stains</topic><topic>Biopsy</topic><topic>Chronic infection</topic><topic>Endoscopy</topic><topic>gastric diseases</topic><topic>Gastritis</topic><topic>Gastritis - microbiology</topic><topic>H. pylori</topic><topic>Helicobacter Infections - diagnosis</topic><topic>Helicobacter Infections - pathology</topic><topic>Helicobacter pylori</topic><topic>histological techniques</topic><topic>Humans</topic><topic>Hyperplasia</topic><topic>Infections</topic><topic>Intestine</topic><topic>Medical prognosis</topic><topic>Metaplasia</topic><topic>Methods</topic><topic>new Giemsa stain</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Sensitivity analysis</topic><topic>Stains & staining</topic><topic>Statistical analysis</topic><topic>Stomach Ulcer - microbiology</topic><topic>Ulcers</topic><topic>Urease</topic><topic>Urease - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fan, Chi‐Chen</creatorcontrib><creatorcontrib>Chen, Chung‐Hsing</creatorcontrib><creatorcontrib>Chou, Chi</creatorcontrib><creatorcontrib>Kao, Ting‐Yu</creatorcontrib><creatorcontrib>Cheng, An Ning</creatorcontrib><creatorcontrib>Lee, Alan Yueh‐Luen</creatorcontrib><creatorcontrib>Kuo, Cheng‐Liang</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Wiley Online Library (Open Access Collection)</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical laboratory analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fan, Chi‐Chen</au><au>Chen, Chung‐Hsing</au><au>Chou, Chi</au><au>Kao, Ting‐Yu</au><au>Cheng, An Ning</au><au>Lee, Alan Yueh‐Luen</au><au>Kuo, Cheng‐Liang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A time‐saving–modified Giemsa stain is a better diagnostic method of Helicobacter pylori infection compared with the rapid urease test</atitle><jtitle>Journal of clinical laboratory analysis</jtitle><addtitle>J Clin Lab Anal</addtitle><date>2020-04</date><risdate>2020</risdate><volume>34</volume><issue>4</issue><spage>e23110</spage><epage>n/a</epage><pages>e23110-n/a</pages><issn>0887-8013</issn><eissn>1098-2825</eissn><abstract>Background
Despite having chronic gastritis, most people infected by Helicobacter pylori (H. pylori) are asymptomatic and have no specific clinical signs and symptoms. H. pylori infection can be diagnosed by several detection methods. Giemsa stain and rapid urease test (CLO test) are the most performed tests of H. pylori infection at first‐line clinical examination because of their simplicity and reliability. However, the sensitivity of CLO test is significantly reduced in patients with atrophic gastritis and intestinal metaplasia, and the weaknesses of Giemsa stain are higher cost and time‐consuming.
Methods
The Giemsa stain was modified in several staining solutions and procedures based on the simplified Giemsa technique described by Gray, Wyatt, & Rathbone (1986). The modified Giemsa stain is examined its efficacy and compared with the CLO test using 233 H. pylori‐infected patients with gastric disease.
Results
The modified Giemsa stain is comparable to the traditional one. Statistical analysis indicated that the modified Giemsa stain obtains greater accuracy in H. pylori‐infected patients with gastritis and ulcer than the CLO test (48.1% vs. 43.7%). Moreover, considering the prognosis of different symptoms of gastric diseases, the modified Giemsa stain has a more accurate prognosis than combination symptoms (P = 1.8E‐05 vs. P = 5.49E‐05). The modified Giemsa stain is confirmed to be better than CLO test using 233 H. pylori‐infected patients with gastric disease.
Conclusions
The modified Giemsa stain is more simplified and time‐saving than traditional Giemsa stain, which is comparable to the traditional one and is confirmed to be better than CLO test using 233 H. pylori‐infected patients with gastric disease. In clinical examination, this modified Giemsa stain can be applied to routine examination and provides quick and accurate diagnosis and prognosis to H. pylori‐infected patients with gastric diseases.</abstract><cop>United States</cop><pub>John Wiley & Sons, Inc</pub><pmid>31733007</pmid><doi>10.1002/jcla.23110</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0001-7145-1878</orcidid><orcidid>https://orcid.org/0000-0003-0252-0571</orcidid><orcidid>https://orcid.org/0000-0003-2401-9390</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Access via Wiley Online Library; Wiley Online Library Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Accuracy Azure Stains Biopsy Chronic infection Endoscopy gastric diseases Gastritis Gastritis - microbiology H. pylori Helicobacter Infections - diagnosis Helicobacter Infections - pathology Helicobacter pylori histological techniques Humans Hyperplasia Infections Intestine Medical prognosis Metaplasia Methods new Giemsa stain Patients Prognosis Sensitivity analysis Stains & staining Statistical analysis Stomach Ulcer - microbiology Ulcers Urease Urease - metabolism |
| title | A time‐saving–modified Giemsa stain is a better diagnostic method of Helicobacter pylori infection compared with the rapid urease test |
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