Association of polymorphisms in MALAT1 with the risk of endometrial cancer in Southern Chinese women
Background Endometrial cancer is the most common gynecologic malignancy worldwide. Polymorphisms in MALAT1 have been demonstrated to play critical roles in cancer. However, the roles of MALAT1 polymorphisms in the etiology of endometrial cancer have not been well documented. Methods We genotyped thr...
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| Veröffentlicht in: | Journal of clinical laboratory analysis 2020-04, Vol.34 (4), p.e23146-n/a |
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| description | Background
Endometrial cancer is the most common gynecologic malignancy worldwide. Polymorphisms in MALAT1 have been demonstrated to play critical roles in cancer. However, the roles of MALAT1 polymorphisms in the etiology of endometrial cancer have not been well documented.
Methods
We genotyped three MALAT1 polymorphisms in 249 endometrial cancer cases and 446 cancer‐free female controls using quantitative polymerase chain reaction with TaqMan probes. To estimate the association between MALAT1 polymorphisms (rs591291 C>T, rs664589 C>G, and rs4102217 G>C) and the risk of endometrial cancer, an unconditional logistic regression model was conducted to calculate the odds ratio (OR) and the 95% confidence interval (CI), adjusting for surgery history, menopause, number of deliveries, BMI, and FIGO stage.
Results
We found that the MALAT1 rs664589 C>G polymorphism was significantly associated with endometrial cancer risk (heterogeneous: adjusted OR = 0.57, 95% CI = 0.34‐0.93, P = .026; homogenous: adjusted OR = 3.74, 95% CI = 1.12‐12.45, P = .032; and recessive: adjusted OR = 4.06, 95% CI = 1.22‐13.48, P = .022). Stratified analysis further demonstrated that the MALAT1 rs664589 C>G polymorphism significantly increased the risk of endometrial cancer susceptibility in patients with no history of surgery, more deliveries, BMI between 25 and 29.9, and FIGO stages II‐III. Compared with the wild‐type GCG haplotype carriers, individuals with CGG haplotypes had a higher risk of developing endometrial cancer.
Conclusion
The MALAT1 rs664589 C>G polymorphism was associated with a significant increase in endometrial cancer risk. |
| doi_str_mv | 10.1002/jcla.23146 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7171330</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2331251624</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4486-136febaa673b5b2f3b867fe399831f1622c46e1a7cb06d18618e32d64ac6e0913</originalsourceid><addsrcrecordid>eNp90U-L1DAYBvAgijuuXvwAEvCyCF3zJm2aXoQy-JcRD67nkKZvbcY2GZPWYb69rbMu6sFTDvnl4QkPIU-BXQNj_OXeDuaaC8jlPbIBVqmMK17cJxumVJkpBuKCPEppzxhTFciH5EKAUstLtSFtnVKwzkwueBo6egjDaQzx0Ls0Juo8_Vjv6hugRzf1dOqRRpe-rRB9G0acojMDtcZbjKv-HOYFRU-3vfOYkB4X5B-TB50ZEj65PS_Jlzevb7bvst2nt--39S6zea5kBkJ22BgjS9EUDe9Eo2TZoagqJaADybnNJYIpbcNkC0qCQsFbmRsrkVUgLsmrc-5hbkZsLfopmkEfohtNPOlgnP77xrtefw0_dAklCMGWgKvbgBi-z5gmPbpkcRiMxzAnzYUAXixN8oU-_4fuwxz98r1FVRyKqixW9eKsbAwpRezuygDT63h6HU__Gm_Bz_6sf0d_r7UAOIOjG_D0nyj9Yburz6E_AW06pNA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2392159754</pqid></control><display><type>article</type><title>Association of polymorphisms in MALAT1 with the risk of endometrial cancer in Southern Chinese women</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><source>Wiley Open Access</source><source>PubMed Central</source><source>Directory of Open Access Journals</source><source>EZB Electronic Journals Library</source><creator>Chen, Guange ; Zhang, Mingyao ; Liang, Zongwen ; Chen, Sailing ; Chen, Feng ; Zhu, Jiawei ; Zhao, Manman ; He, Jing ; Hua, Wenfeng ; Duan, Ping</creator><creatorcontrib>Chen, Guange ; Zhang, Mingyao ; Liang, Zongwen ; Chen, Sailing ; Chen, Feng ; Zhu, Jiawei ; Zhao, Manman ; He, Jing ; Hua, Wenfeng ; Duan, Ping</creatorcontrib><description>Background
Endometrial cancer is the most common gynecologic malignancy worldwide. Polymorphisms in MALAT1 have been demonstrated to play critical roles in cancer. However, the roles of MALAT1 polymorphisms in the etiology of endometrial cancer have not been well documented.
Methods
We genotyped three MALAT1 polymorphisms in 249 endometrial cancer cases and 446 cancer‐free female controls using quantitative polymerase chain reaction with TaqMan probes. To estimate the association between MALAT1 polymorphisms (rs591291 C>T, rs664589 C>G, and rs4102217 G>C) and the risk of endometrial cancer, an unconditional logistic regression model was conducted to calculate the odds ratio (OR) and the 95% confidence interval (CI), adjusting for surgery history, menopause, number of deliveries, BMI, and FIGO stage.
Results
We found that the MALAT1 rs664589 C>G polymorphism was significantly associated with endometrial cancer risk (heterogeneous: adjusted OR = 0.57, 95% CI = 0.34‐0.93, P = .026; homogenous: adjusted OR = 3.74, 95% CI = 1.12‐12.45, P = .032; and recessive: adjusted OR = 4.06, 95% CI = 1.22‐13.48, P = .022). Stratified analysis further demonstrated that the MALAT1 rs664589 C>G polymorphism significantly increased the risk of endometrial cancer susceptibility in patients with no history of surgery, more deliveries, BMI between 25 and 29.9, and FIGO stages II‐III. Compared with the wild‐type GCG haplotype carriers, individuals with CGG haplotypes had a higher risk of developing endometrial cancer.
Conclusion
The MALAT1 rs664589 C>G polymorphism was associated with a significant increase in endometrial cancer risk.</description><identifier>ISSN: 0887-8013</identifier><identifier>EISSN: 1098-2825</identifier><identifier>DOI: 10.1002/jcla.23146</identifier><identifier>PMID: 31880028</identifier><language>eng</language><publisher>United States: John Wiley & Sons, Inc</publisher><subject>Adult ; Age ; Aged ; Aged, 80 and over ; Asian Continental Ancestry Group - genetics ; Cancer ; Case-Control Studies ; Confidence intervals ; Deoxyribonucleic acid ; DNA ; Endometrial cancer ; Endometrial Neoplasms - genetics ; Endometrium ; Etiology ; Female ; Genetic Association Studies ; Genetic Predisposition to Disease ; Genotype & phenotype ; Haplotypes ; Haplotypes - genetics ; Health risk assessment ; Humans ; Logistic Models ; MALAT1 ; Malignancy ; Menopause ; Metastasis ; Middle Aged ; Polymerase chain reaction ; Polymorphism, Single Nucleotide - genetics ; risk ; Risk Factors ; RNA, Long Noncoding - genetics ; single nucleotide polymorphisms ; Surgery ; Womens health</subject><ispartof>Journal of clinical laboratory analysis, 2020-04, Vol.34 (4), p.e23146-n/a</ispartof><rights>2019 The Authors. published by Wiley Periodicals, Inc.</rights><rights>2019 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals, Inc.</rights><rights>2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4486-136febaa673b5b2f3b867fe399831f1622c46e1a7cb06d18618e32d64ac6e0913</citedby><cites>FETCH-LOGICAL-c4486-136febaa673b5b2f3b867fe399831f1622c46e1a7cb06d18618e32d64ac6e0913</cites><orcidid>0000-0002-1954-2892 ; 0000-0003-0177-182X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171330/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171330/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,1411,11541,27901,27902,45550,45551,46027,46451,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31880028$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Guange</creatorcontrib><creatorcontrib>Zhang, Mingyao</creatorcontrib><creatorcontrib>Liang, Zongwen</creatorcontrib><creatorcontrib>Chen, Sailing</creatorcontrib><creatorcontrib>Chen, Feng</creatorcontrib><creatorcontrib>Zhu, Jiawei</creatorcontrib><creatorcontrib>Zhao, Manman</creatorcontrib><creatorcontrib>He, Jing</creatorcontrib><creatorcontrib>Hua, Wenfeng</creatorcontrib><creatorcontrib>Duan, Ping</creatorcontrib><title>Association of polymorphisms in MALAT1 with the risk of endometrial cancer in Southern Chinese women</title><title>Journal of clinical laboratory analysis</title><addtitle>J Clin Lab Anal</addtitle><description>Background
Endometrial cancer is the most common gynecologic malignancy worldwide. Polymorphisms in MALAT1 have been demonstrated to play critical roles in cancer. However, the roles of MALAT1 polymorphisms in the etiology of endometrial cancer have not been well documented.
Methods
We genotyped three MALAT1 polymorphisms in 249 endometrial cancer cases and 446 cancer‐free female controls using quantitative polymerase chain reaction with TaqMan probes. To estimate the association between MALAT1 polymorphisms (rs591291 C>T, rs664589 C>G, and rs4102217 G>C) and the risk of endometrial cancer, an unconditional logistic regression model was conducted to calculate the odds ratio (OR) and the 95% confidence interval (CI), adjusting for surgery history, menopause, number of deliveries, BMI, and FIGO stage.
Results
We found that the MALAT1 rs664589 C>G polymorphism was significantly associated with endometrial cancer risk (heterogeneous: adjusted OR = 0.57, 95% CI = 0.34‐0.93, P = .026; homogenous: adjusted OR = 3.74, 95% CI = 1.12‐12.45, P = .032; and recessive: adjusted OR = 4.06, 95% CI = 1.22‐13.48, P = .022). Stratified analysis further demonstrated that the MALAT1 rs664589 C>G polymorphism significantly increased the risk of endometrial cancer susceptibility in patients with no history of surgery, more deliveries, BMI between 25 and 29.9, and FIGO stages II‐III. Compared with the wild‐type GCG haplotype carriers, individuals with CGG haplotypes had a higher risk of developing endometrial cancer.
Conclusion
The MALAT1 rs664589 C>G polymorphism was associated with a significant increase in endometrial cancer risk.</description><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>Cancer</subject><subject>Case-Control Studies</subject><subject>Confidence intervals</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Endometrial cancer</subject><subject>Endometrial Neoplasms - genetics</subject><subject>Endometrium</subject><subject>Etiology</subject><subject>Female</subject><subject>Genetic Association Studies</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype & phenotype</subject><subject>Haplotypes</subject><subject>Haplotypes - genetics</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>MALAT1</subject><subject>Malignancy</subject><subject>Menopause</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Polymerase chain reaction</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>risk</subject><subject>Risk Factors</subject><subject>RNA, Long Noncoding - genetics</subject><subject>single nucleotide polymorphisms</subject><subject>Surgery</subject><subject>Womens health</subject><issn>0887-8013</issn><issn>1098-2825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp90U-L1DAYBvAgijuuXvwAEvCyCF3zJm2aXoQy-JcRD67nkKZvbcY2GZPWYb69rbMu6sFTDvnl4QkPIU-BXQNj_OXeDuaaC8jlPbIBVqmMK17cJxumVJkpBuKCPEppzxhTFciH5EKAUstLtSFtnVKwzkwueBo6egjDaQzx0Ls0Juo8_Vjv6hugRzf1dOqRRpe-rRB9G0acojMDtcZbjKv-HOYFRU-3vfOYkB4X5B-TB50ZEj65PS_Jlzevb7bvst2nt--39S6zea5kBkJ22BgjS9EUDe9Eo2TZoagqJaADybnNJYIpbcNkC0qCQsFbmRsrkVUgLsmrc-5hbkZsLfopmkEfohtNPOlgnP77xrtefw0_dAklCMGWgKvbgBi-z5gmPbpkcRiMxzAnzYUAXixN8oU-_4fuwxz98r1FVRyKqixW9eKsbAwpRezuygDT63h6HU__Gm_Bz_6sf0d_r7UAOIOjG_D0nyj9Yburz6E_AW06pNA</recordid><startdate>202004</startdate><enddate>202004</enddate><creator>Chen, Guange</creator><creator>Zhang, Mingyao</creator><creator>Liang, Zongwen</creator><creator>Chen, Sailing</creator><creator>Chen, Feng</creator><creator>Zhu, Jiawei</creator><creator>Zhao, Manman</creator><creator>He, Jing</creator><creator>Hua, Wenfeng</creator><creator>Duan, Ping</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1954-2892</orcidid><orcidid>https://orcid.org/0000-0003-0177-182X</orcidid></search><sort><creationdate>202004</creationdate><title>Association of polymorphisms in MALAT1 with the risk of endometrial cancer in Southern Chinese women</title><author>Chen, Guange ; Zhang, Mingyao ; Liang, Zongwen ; Chen, Sailing ; Chen, Feng ; Zhu, Jiawei ; Zhao, Manman ; He, Jing ; Hua, Wenfeng ; Duan, Ping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4486-136febaa673b5b2f3b867fe399831f1622c46e1a7cb06d18618e32d64ac6e0913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Asian Continental Ancestry Group - genetics</topic><topic>Cancer</topic><topic>Case-Control Studies</topic><topic>Confidence intervals</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Endometrial cancer</topic><topic>Endometrial Neoplasms - genetics</topic><topic>Endometrium</topic><topic>Etiology</topic><topic>Female</topic><topic>Genetic Association Studies</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype & phenotype</topic><topic>Haplotypes</topic><topic>Haplotypes - genetics</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Logistic Models</topic><topic>MALAT1</topic><topic>Malignancy</topic><topic>Menopause</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Polymerase chain reaction</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>risk</topic><topic>Risk Factors</topic><topic>RNA, Long Noncoding - genetics</topic><topic>single nucleotide polymorphisms</topic><topic>Surgery</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Guange</creatorcontrib><creatorcontrib>Zhang, Mingyao</creatorcontrib><creatorcontrib>Liang, Zongwen</creatorcontrib><creatorcontrib>Chen, Sailing</creatorcontrib><creatorcontrib>Chen, Feng</creatorcontrib><creatorcontrib>Zhu, Jiawei</creatorcontrib><creatorcontrib>Zhao, Manman</creatorcontrib><creatorcontrib>He, Jing</creatorcontrib><creatorcontrib>Hua, Wenfeng</creatorcontrib><creatorcontrib>Duan, Ping</creatorcontrib><collection>Wiley Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>ProQuest - Health & Medical Complete保健、医学与药学数据库</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Public Health Database (Proquest)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical laboratory analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Guange</au><au>Zhang, Mingyao</au><au>Liang, Zongwen</au><au>Chen, Sailing</au><au>Chen, Feng</au><au>Zhu, Jiawei</au><au>Zhao, Manman</au><au>He, Jing</au><au>Hua, Wenfeng</au><au>Duan, Ping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of polymorphisms in MALAT1 with the risk of endometrial cancer in Southern Chinese women</atitle><jtitle>Journal of clinical laboratory analysis</jtitle><addtitle>J Clin Lab Anal</addtitle><date>2020-04</date><risdate>2020</risdate><volume>34</volume><issue>4</issue><spage>e23146</spage><epage>n/a</epage><pages>e23146-n/a</pages><issn>0887-8013</issn><eissn>1098-2825</eissn><abstract>Background
Endometrial cancer is the most common gynecologic malignancy worldwide. Polymorphisms in MALAT1 have been demonstrated to play critical roles in cancer. However, the roles of MALAT1 polymorphisms in the etiology of endometrial cancer have not been well documented.
Methods
We genotyped three MALAT1 polymorphisms in 249 endometrial cancer cases and 446 cancer‐free female controls using quantitative polymerase chain reaction with TaqMan probes. To estimate the association between MALAT1 polymorphisms (rs591291 C>T, rs664589 C>G, and rs4102217 G>C) and the risk of endometrial cancer, an unconditional logistic regression model was conducted to calculate the odds ratio (OR) and the 95% confidence interval (CI), adjusting for surgery history, menopause, number of deliveries, BMI, and FIGO stage.
Results
We found that the MALAT1 rs664589 C>G polymorphism was significantly associated with endometrial cancer risk (heterogeneous: adjusted OR = 0.57, 95% CI = 0.34‐0.93, P = .026; homogenous: adjusted OR = 3.74, 95% CI = 1.12‐12.45, P = .032; and recessive: adjusted OR = 4.06, 95% CI = 1.22‐13.48, P = .022). Stratified analysis further demonstrated that the MALAT1 rs664589 C>G polymorphism significantly increased the risk of endometrial cancer susceptibility in patients with no history of surgery, more deliveries, BMI between 25 and 29.9, and FIGO stages II‐III. Compared with the wild‐type GCG haplotype carriers, individuals with CGG haplotypes had a higher risk of developing endometrial cancer.
Conclusion
The MALAT1 rs664589 C>G polymorphism was associated with a significant increase in endometrial cancer risk.</abstract><cop>United States</cop><pub>John Wiley & Sons, Inc</pub><pmid>31880028</pmid><doi>10.1002/jcla.23146</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-1954-2892</orcidid><orcidid>https://orcid.org/0000-0003-0177-182X</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library All Journals; Wiley Open Access; PubMed Central; Directory of Open Access Journals; EZB Electronic Journals Library |
| subjects | Adult Age Aged Aged, 80 and over Asian Continental Ancestry Group - genetics Cancer Case-Control Studies Confidence intervals Deoxyribonucleic acid DNA Endometrial cancer Endometrial Neoplasms - genetics Endometrium Etiology Female Genetic Association Studies Genetic Predisposition to Disease Genotype & phenotype Haplotypes Haplotypes - genetics Health risk assessment Humans Logistic Models MALAT1 Malignancy Menopause Metastasis Middle Aged Polymerase chain reaction Polymorphism, Single Nucleotide - genetics risk Risk Factors RNA, Long Noncoding - genetics single nucleotide polymorphisms Surgery Womens health |
| title | Association of polymorphisms in MALAT1 with the risk of endometrial cancer in Southern Chinese women |
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