Kinesin family member 2A high expression correlates with advanced tumor stages and worse prognosis in non‐small cell lung cancer patients
Background This present study was to explore the association of kinesin family member 2A (KIF2A) expression with clinicopathological features and survival profiles, and the effect of KIF2A on cell proliferation and chemosensitivity in non‐small cell lung cancer (NSCLC). Methods Tumor and paired adja...
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| Veröffentlicht in: | Journal of clinical laboratory analysis 2020-04, Vol.34 (4), p.e23135-n/a |
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| description | Background
This present study was to explore the association of kinesin family member 2A (KIF2A) expression with clinicopathological features and survival profiles, and the effect of KIF2A on cell proliferation and chemosensitivity in non‐small cell lung cancer (NSCLC).
Methods
Tumor and paired adjacent specimens were collected from 380 patients with NSCLC underwent resection for immunohistochemistry assay of KIF2A expression. In vitro, the effect of KIF2A on cell proliferation, chemosensitivity to cisplatin/vinorelbine was detected via KIF2A plasmids transfection into NCI‐H1299 NSCLC cells.
Results
Kinesin family member 2A expression was upregulated in tumor tissues compared with adjacent tissues, and tumor tissue KIF2A high expression was associated with higher pathological grade (P |
| doi_str_mv | 10.1002/jcla.23135 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7171296</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2392164312</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4485-88a148a4b9903451154cae31cc61d89a0d9fe594da1e972def2e76483bda8d3c3</originalsourceid><addsrcrecordid>eNp9kT2PEzEQhi0E4sJBww9AlmhOSHv4Yz_sBimK-I5EA7Xl2LMbR7v2Yu9eSHf9NfxGfgkOOU5AQTNTzKNnZvQi9JSSS0oIe7kzvb5knPLqHlpQIkXBBKvuowURoikEofwMPUppRwgRktYP0RmnohJ12SzQzUfnITmPWz24_oAHGDYQMVvireu2GL6NEVJywWMTYoReT5Dw3k1brO2V9gYsnuYhRJwm3eWR9hbvQ0yAxxg6H5JLONt98D-uv6dB9z02kEs_-w6boyDiUU8O_JQeowet7hM8ue3n6Mub159X74r1p7fvV8t1YcpSVIUQmpZClxspCS8rSqvSaODUmJpaITWxsoVKllZTkA2z0DJo6lLwjdXCcsPP0auTd5w3A1iTd0fdqzG6QceDCtqpvyfebVUXrlRDG8pknQUXt4IYvs6QJjW4dHxLewhzUowz2XApKpLR5_-guzBHn9_LlGS0LjllmXpxokwMKUVo746hRB0zVseM1a-MM_zsz_Pv0N-hZoCegL3r4fAflfqwWi9P0p9marXE</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2392164312</pqid></control><display><type>article</type><title>Kinesin family member 2A high expression correlates with advanced tumor stages and worse prognosis in non‐small cell lung cancer patients</title><source>MEDLINE</source><source>Wiley Journals</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Wiley-Blackwell Open Access Titles</source><source>PubMed Central</source><creator>Wang, Guanjie ; Wang, Zheng ; Yu, Haizhen</creator><creatorcontrib>Wang, Guanjie ; Wang, Zheng ; Yu, Haizhen</creatorcontrib><description>Background
This present study was to explore the association of kinesin family member 2A (KIF2A) expression with clinicopathological features and survival profiles, and the effect of KIF2A on cell proliferation and chemosensitivity in non‐small cell lung cancer (NSCLC).
Methods
Tumor and paired adjacent specimens were collected from 380 patients with NSCLC underwent resection for immunohistochemistry assay of KIF2A expression. In vitro, the effect of KIF2A on cell proliferation, chemosensitivity to cisplatin/vinorelbine was detected via KIF2A plasmids transfection into NCI‐H1299 NSCLC cells.
Results
Kinesin family member 2A expression was upregulated in tumor tissues compared with adjacent tissues, and tumor tissue KIF2A high expression was associated with higher pathological grade (P < .001), larger tumor size (P = .021), lymph node metastasis (P = .044), and increased tumor‐node‐metastasis stage (P = .001). As for survival profiles, disease‐free survival (P < .001) and overall survival (P < .001) were worse in patients with KIF2A high expression compared with those with KIF2A low expression. Multivariate Cox's regression exhibited that KIF2A high expression was an independent predictive factor for lower DFS (P < .001) and OS (P < .001). In vitro, KIF2A promoted proliferation and decreased chemosensitivity to cisplatin but not vinorelbine in NCI‐H1299 NSCLC cells.
Conclusions
The correlation of KIF2A expression with tumor features, survival, and its cellular function implies its potential as a prognostic biomarker and a treatment target in NSCLC.</description><identifier>ISSN: 0887-8013</identifier><identifier>EISSN: 1098-2825</identifier><identifier>DOI: 10.1002/jcla.23135</identifier><identifier>PMID: 31858647</identifier><language>eng</language><publisher>United States: John Wiley & Sons, Inc</publisher><subject>Antigens ; Cancer therapies ; Carcinoma, Non-Small-Cell Lung - drug therapy ; Carcinoma, Non-Small-Cell Lung - genetics ; Carcinoma, Non-Small-Cell Lung - pathology ; Cell division ; Cell growth ; Cell Line, Tumor ; Cell proliferation ; Cell Proliferation - genetics ; chemosensitivity ; Chemotherapy ; Cisplatin ; clinical features ; Disease-Free Survival ; Female ; Gene Expression Regulation, Neoplastic ; Hospitals ; Humans ; Immunohistochemistry ; Kinesin ; Kinesin - genetics ; Kinesin - metabolism ; kinesin family member 2A ; Lung cancer ; Lung Neoplasms - drug therapy ; Lung Neoplasms - genetics ; Lung Neoplasms - pathology ; Lymph nodes ; Lymphatic system ; Male ; Medical prognosis ; Metastases ; Metastasis ; Middle Aged ; Multivariate Analysis ; Neoplasm Staging ; Non-small cell lung carcinoma ; non‐small cell lung cancer ; Plasmids ; Prognosis ; Proportional Hazards Models ; Small cell lung carcinoma ; Transfection ; Vinorelbine</subject><ispartof>Journal of clinical laboratory analysis, 2020-04, Vol.34 (4), p.e23135-n/a</ispartof><rights>2019 The Authors. published by Wiley Periodicals, Inc.</rights><rights>2019 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals, Inc.</rights><rights>2020. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4485-88a148a4b9903451154cae31cc61d89a0d9fe594da1e972def2e76483bda8d3c3</citedby><cites>FETCH-LOGICAL-c4485-88a148a4b9903451154cae31cc61d89a0d9fe594da1e972def2e76483bda8d3c3</cites><orcidid>0000-0002-2854-0688</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171296/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171296/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,1417,11562,27924,27925,45574,45575,46052,46476,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31858647$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Guanjie</creatorcontrib><creatorcontrib>Wang, Zheng</creatorcontrib><creatorcontrib>Yu, Haizhen</creatorcontrib><title>Kinesin family member 2A high expression correlates with advanced tumor stages and worse prognosis in non‐small cell lung cancer patients</title><title>Journal of clinical laboratory analysis</title><addtitle>J Clin Lab Anal</addtitle><description>Background
This present study was to explore the association of kinesin family member 2A (KIF2A) expression with clinicopathological features and survival profiles, and the effect of KIF2A on cell proliferation and chemosensitivity in non‐small cell lung cancer (NSCLC).
Methods
Tumor and paired adjacent specimens were collected from 380 patients with NSCLC underwent resection for immunohistochemistry assay of KIF2A expression. In vitro, the effect of KIF2A on cell proliferation, chemosensitivity to cisplatin/vinorelbine was detected via KIF2A plasmids transfection into NCI‐H1299 NSCLC cells.
Results
Kinesin family member 2A expression was upregulated in tumor tissues compared with adjacent tissues, and tumor tissue KIF2A high expression was associated with higher pathological grade (P < .001), larger tumor size (P = .021), lymph node metastasis (P = .044), and increased tumor‐node‐metastasis stage (P = .001). As for survival profiles, disease‐free survival (P < .001) and overall survival (P < .001) were worse in patients with KIF2A high expression compared with those with KIF2A low expression. Multivariate Cox's regression exhibited that KIF2A high expression was an independent predictive factor for lower DFS (P < .001) and OS (P < .001). In vitro, KIF2A promoted proliferation and decreased chemosensitivity to cisplatin but not vinorelbine in NCI‐H1299 NSCLC cells.
Conclusions
The correlation of KIF2A expression with tumor features, survival, and its cellular function implies its potential as a prognostic biomarker and a treatment target in NSCLC.</description><subject>Antigens</subject><subject>Cancer therapies</subject><subject>Carcinoma, Non-Small-Cell Lung - drug therapy</subject><subject>Carcinoma, Non-Small-Cell Lung - genetics</subject><subject>Carcinoma, Non-Small-Cell Lung - pathology</subject><subject>Cell division</subject><subject>Cell growth</subject><subject>Cell Line, Tumor</subject><subject>Cell proliferation</subject><subject>Cell Proliferation - genetics</subject><subject>chemosensitivity</subject><subject>Chemotherapy</subject><subject>Cisplatin</subject><subject>clinical features</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Kinesin</subject><subject>Kinesin - genetics</subject><subject>Kinesin - metabolism</subject><subject>kinesin family member 2A</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - drug therapy</subject><subject>Lung Neoplasms - genetics</subject><subject>Lung Neoplasms - pathology</subject><subject>Lymph nodes</subject><subject>Lymphatic system</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Neoplasm Staging</subject><subject>Non-small cell lung carcinoma</subject><subject>non‐small cell lung cancer</subject><subject>Plasmids</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Small cell lung carcinoma</subject><subject>Transfection</subject><subject>Vinorelbine</subject><issn>0887-8013</issn><issn>1098-2825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kT2PEzEQhi0E4sJBww9AlmhOSHv4Yz_sBimK-I5EA7Xl2LMbR7v2Yu9eSHf9NfxGfgkOOU5AQTNTzKNnZvQi9JSSS0oIe7kzvb5knPLqHlpQIkXBBKvuowURoikEofwMPUppRwgRktYP0RmnohJ12SzQzUfnITmPWz24_oAHGDYQMVvireu2GL6NEVJywWMTYoReT5Dw3k1brO2V9gYsnuYhRJwm3eWR9hbvQ0yAxxg6H5JLONt98D-uv6dB9z02kEs_-w6boyDiUU8O_JQeowet7hM8ue3n6Mub159X74r1p7fvV8t1YcpSVIUQmpZClxspCS8rSqvSaODUmJpaITWxsoVKllZTkA2z0DJo6lLwjdXCcsPP0auTd5w3A1iTd0fdqzG6QceDCtqpvyfebVUXrlRDG8pknQUXt4IYvs6QJjW4dHxLewhzUowz2XApKpLR5_-guzBHn9_LlGS0LjllmXpxokwMKUVo746hRB0zVseM1a-MM_zsz_Pv0N-hZoCegL3r4fAflfqwWi9P0p9marXE</recordid><startdate>202004</startdate><enddate>202004</enddate><creator>Wang, Guanjie</creator><creator>Wang, Zheng</creator><creator>Yu, Haizhen</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-2854-0688</orcidid></search><sort><creationdate>202004</creationdate><title>Kinesin family member 2A high expression correlates with advanced tumor stages and worse prognosis in non‐small cell lung cancer patients</title><author>Wang, Guanjie ; Wang, Zheng ; Yu, Haizhen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4485-88a148a4b9903451154cae31cc61d89a0d9fe594da1e972def2e76483bda8d3c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Antigens</topic><topic>Cancer therapies</topic><topic>Carcinoma, Non-Small-Cell Lung - drug therapy</topic><topic>Carcinoma, Non-Small-Cell Lung - genetics</topic><topic>Carcinoma, Non-Small-Cell Lung - pathology</topic><topic>Cell division</topic><topic>Cell growth</topic><topic>Cell Line, Tumor</topic><topic>Cell proliferation</topic><topic>Cell Proliferation - genetics</topic><topic>chemosensitivity</topic><topic>Chemotherapy</topic><topic>Cisplatin</topic><topic>clinical features</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Kinesin</topic><topic>Kinesin - genetics</topic><topic>Kinesin - metabolism</topic><topic>kinesin family member 2A</topic><topic>Lung cancer</topic><topic>Lung Neoplasms - drug therapy</topic><topic>Lung Neoplasms - genetics</topic><topic>Lung Neoplasms - pathology</topic><topic>Lymph nodes</topic><topic>Lymphatic system</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Neoplasm Staging</topic><topic>Non-small cell lung carcinoma</topic><topic>non‐small cell lung cancer</topic><topic>Plasmids</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Small cell lung carcinoma</topic><topic>Transfection</topic><topic>Vinorelbine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Guanjie</creatorcontrib><creatorcontrib>Wang, Zheng</creatorcontrib><creatorcontrib>Yu, Haizhen</creatorcontrib><collection>Wiley-Blackwell Open Access Titles</collection><collection>Wiley Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical laboratory analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Guanjie</au><au>Wang, Zheng</au><au>Yu, Haizhen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Kinesin family member 2A high expression correlates with advanced tumor stages and worse prognosis in non‐small cell lung cancer patients</atitle><jtitle>Journal of clinical laboratory analysis</jtitle><addtitle>J Clin Lab Anal</addtitle><date>2020-04</date><risdate>2020</risdate><volume>34</volume><issue>4</issue><spage>e23135</spage><epage>n/a</epage><pages>e23135-n/a</pages><issn>0887-8013</issn><eissn>1098-2825</eissn><abstract>Background
This present study was to explore the association of kinesin family member 2A (KIF2A) expression with clinicopathological features and survival profiles, and the effect of KIF2A on cell proliferation and chemosensitivity in non‐small cell lung cancer (NSCLC).
Methods
Tumor and paired adjacent specimens were collected from 380 patients with NSCLC underwent resection for immunohistochemistry assay of KIF2A expression. In vitro, the effect of KIF2A on cell proliferation, chemosensitivity to cisplatin/vinorelbine was detected via KIF2A plasmids transfection into NCI‐H1299 NSCLC cells.
Results
Kinesin family member 2A expression was upregulated in tumor tissues compared with adjacent tissues, and tumor tissue KIF2A high expression was associated with higher pathological grade (P < .001), larger tumor size (P = .021), lymph node metastasis (P = .044), and increased tumor‐node‐metastasis stage (P = .001). As for survival profiles, disease‐free survival (P < .001) and overall survival (P < .001) were worse in patients with KIF2A high expression compared with those with KIF2A low expression. Multivariate Cox's regression exhibited that KIF2A high expression was an independent predictive factor for lower DFS (P < .001) and OS (P < .001). In vitro, KIF2A promoted proliferation and decreased chemosensitivity to cisplatin but not vinorelbine in NCI‐H1299 NSCLC cells.
Conclusions
The correlation of KIF2A expression with tumor features, survival, and its cellular function implies its potential as a prognostic biomarker and a treatment target in NSCLC.</abstract><cop>United States</cop><pub>John Wiley & Sons, Inc</pub><pmid>31858647</pmid><doi>10.1002/jcla.23135</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-2854-0688</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Journals; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley-Blackwell Open Access Titles; PubMed Central |
| subjects | Antigens Cancer therapies Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - pathology Cell division Cell growth Cell Line, Tumor Cell proliferation Cell Proliferation - genetics chemosensitivity Chemotherapy Cisplatin clinical features Disease-Free Survival Female Gene Expression Regulation, Neoplastic Hospitals Humans Immunohistochemistry Kinesin Kinesin - genetics Kinesin - metabolism kinesin family member 2A Lung cancer Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - pathology Lymph nodes Lymphatic system Male Medical prognosis Metastases Metastasis Middle Aged Multivariate Analysis Neoplasm Staging Non-small cell lung carcinoma non‐small cell lung cancer Plasmids Prognosis Proportional Hazards Models Small cell lung carcinoma Transfection Vinorelbine |
| title | Kinesin family member 2A high expression correlates with advanced tumor stages and worse prognosis in non‐small cell lung cancer patients |
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