Glucocerebrosidases catalyze a transgalactosylation reaction that yields a newly-identified brain sterol metabolite, galactosylated cholesterol

β-Glucocerebrosidase (GBA) hydrolyzes glucosylceramide (GlcCer) to generate ceramide. Previously, we demonstrated that lysosomal GBA1 and nonlysosomal GBA2 possess not only GlcCer hydrolase activity, but also transglucosylation activity to transfer the glucose residue from GlcCer to cholesterol to f...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of biological chemistry 2020-04, Vol.295 (16), p.5257-5277
Hauptverfasser:	Akiyama, Hisako, Ide, Mitsuko, Nagatsuka, Yasuko, Sayano, Tomoko, Nakanishi, Etsuro, Uemura, Norihito, Yuyama, Kohei, Yamaguchi, Yoshiki, Kamiguchi, Hiroyuki, Takahashi, Ryosuke, Aerts, Johannes M.F.G., Greimel, Peter, Hirabayashi, Yoshio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals brain Brain - cytology Brain - metabolism Cell Line, Tumor Cells, Cultured cholesterol Cholesterol - analogs & derivatives Cholesterol - metabolism Female Galactose - metabolism galactosylated cholesterol Galactosylceramides - metabolism glucocerebrosidase Glucosylceramidase - genetics Glucosylceramidase - metabolism glycolipid Humans Lipids Male mass spectrometry (MS) Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred ICR Myelin Sheath - metabolism Neuroglia - metabolism Neurons - metabolism Oryzias Rats Rats, Wistar sterol sterylglycoside transglycosylation β-cholesterylgalactoside
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!