Biochemical and structural insights into how amino acids regulate pyruvate kinase muscle isoform 2

Pyruvate kinase muscle isoform 2 (PKM2) is a key glycolytic enzyme involved in ATP generation and critical for cancer metabolism. PKM2 is expressed in many human cancers and is regulated by complex mechanisms that promote tumor growth and proliferation. Therefore, it is considered an attractive ther...

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Veröffentlicht in:	The Journal of biological chemistry 2020-04, Vol.295 (16), p.5390-5403
Hauptverfasser:	Nandi, Suparno, Dey, Mishtu
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric Regulation Allosteric Site amino acids Amino Acids - chemistry Amino Acids - metabolism asparagine aspartate cancer metabolism Carrier Proteins - antagonists & inhibitors Carrier Proteins - chemistry Carrier Proteins - metabolism crystal structure Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology enzyme kinetics fluorescence binding glycolysis Humans Membrane Proteins - antagonists & inhibitors Membrane Proteins - chemistry Membrane Proteins - metabolism Molecular Biophysics oligomerization Protein Binding Protein Multimerization pyruvate kinase pyruvate kinase muscle isoform 2 (PKM2) Thyroid Hormone-Binding Proteins Thyroid Hormones - chemistry Thyroid Hormones - metabolism valine valines
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