Tumor-Derived Extracellular Vesicles Breach the Intact Blood–Brain Barrier via Transcytosis

The restrictive nature of the blood–brain barrier (BBB) creates a major challenge for brain drug delivery with current nanomedicines lacking the ability to cross the BBB. Extracellular vesicles (EVs) have been shown to contribute to the progression of a variety of brain diseases including metastatic...

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Veröffentlicht in:	ACS nano 2019-12, Vol.13 (12), p.13853-13865
Hauptverfasser:	Morad, Golnaz, Carman, Christopher V, Hagedorn, Elliott J, Perlin, Julie R, Zon, Leonard I, Mustafaoglu, Nur, Park, Tae-Eun, Ingber, Donald E, Daisy, Cassandra C, Moses, Marsha A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood-Brain Barrier - metabolism Brain Neoplasms - secondary Breast Neoplasms - metabolism Caveolins - metabolism Cell Line, Tumor Down-Regulation Endosomes - metabolism Endothelium - metabolism Extracellular Vesicles - metabolism Extracellular Vesicles - ultrastructure Female Humans Mice, Nude Protein Transport rab GTP-Binding Proteins - metabolism SNARE Proteins - metabolism Transcytosis
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