Delivery of RNAi mediators
Delivering polynucleotides into animals has been a major challenge facing their success as therapeutic agents. Given the matured understanding of antibody‐mediated delivery techniques, it is possible to rationally design delivery vehicles that circulate in the blood stream and are specifically deliv...
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| Veröffentlicht in: | Wiley interdisciplinary reviews. RNA 2010-09, Vol.1 (2), p.341-350 |
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| container_title | Wiley interdisciplinary reviews. RNA |
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| creator | Ford, Lance P. Toloue, Masoud M. |
| description | Delivering polynucleotides into animals has been a major challenge facing their success as therapeutic agents. Given the matured understanding of antibody‐mediated delivery techniques, it is possible to rationally design delivery vehicles that circulate in the blood stream and are specifically delivered into target organs. If the targeting moiety is designed to contain the cargo of an RNAi mediator without impacting its paratope, directed delivery can be achieved. In this article, we review the state of art in delivery technology for RNA mediators and address how this technique could soon be used to enhance the efficacy of the numerous small RNA therapeutic programs currently under evaluation. Copyright © 2010 John Wiley & Sons, Ltd.
This article is categorized under:
Regulatory RNAs/RNAi/Riboswitches > RNAi: Mechanisms of Action
RNA Methods > RNA Analyses in Cells
RNA in Disease and Development > RNA in Disease |
| doi_str_mv | 10.1002/wrna.12 |
| format | Article |
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This article is categorized under:
Regulatory RNAs/RNAi/Riboswitches > RNAi: Mechanisms of Action
RNA Methods > RNA Analyses in Cells
RNA in Disease and Development > RNA in Disease</description><identifier>ISSN: 1757-7004</identifier><identifier>EISSN: 1757-7012</identifier><identifier>DOI: 10.1002/wrna.12</identifier><identifier>PMID: 21935894</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Animals ; Clinical Trials as Topic ; Drug Delivery Systems - methods ; Drug Discovery - methods ; Focus ; Gene Transfer Techniques ; Humans ; Models, Animal ; Polynucleotides ; Ribonucleic acid ; Riboswitches ; RNA ; RNA Analyses in Cells ; RNA in Disease ; RNA Interference - physiology ; RNA, Small Interfering - administration & dosage ; RNA-mediated interference ; RNAi: Mechanisms of Action ; Validation Studies as Topic</subject><ispartof>Wiley interdisciplinary reviews. RNA, 2010-09, Vol.1 (2), p.341-350</ispartof><rights>Copyright © 2010 John Wiley & Sons, Ltd.</rights><rights>Copyright Wiley Subscription Services, Inc. Sep/Oct 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5362-3d668c4b2daf5ab628a1f94f4b246cba4e0abb716ffcc6479c88d4561f7a6a073</citedby><cites>FETCH-LOGICAL-c5362-3d668c4b2daf5ab628a1f94f4b246cba4e0abb716ffcc6479c88d4561f7a6a073</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fwrna.12$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fwrna.12$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21935894$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ford, Lance P.</creatorcontrib><creatorcontrib>Toloue, Masoud M.</creatorcontrib><title>Delivery of RNAi mediators</title><title>Wiley interdisciplinary reviews. RNA</title><addtitle>WIREs RNA</addtitle><description>Delivering polynucleotides into animals has been a major challenge facing their success as therapeutic agents. Given the matured understanding of antibody‐mediated delivery techniques, it is possible to rationally design delivery vehicles that circulate in the blood stream and are specifically delivered into target organs. If the targeting moiety is designed to contain the cargo of an RNAi mediator without impacting its paratope, directed delivery can be achieved. In this article, we review the state of art in delivery technology for RNA mediators and address how this technique could soon be used to enhance the efficacy of the numerous small RNA therapeutic programs currently under evaluation. Copyright © 2010 John Wiley & Sons, Ltd.
This article is categorized under:
Regulatory RNAs/RNAi/Riboswitches > RNAi: Mechanisms of Action
RNA Methods > RNA Analyses in Cells
RNA in Disease and Development > RNA in Disease</description><subject>Animals</subject><subject>Clinical Trials as Topic</subject><subject>Drug Delivery Systems - methods</subject><subject>Drug Discovery - methods</subject><subject>Focus</subject><subject>Gene Transfer Techniques</subject><subject>Humans</subject><subject>Models, Animal</subject><subject>Polynucleotides</subject><subject>Ribonucleic acid</subject><subject>Riboswitches</subject><subject>RNA</subject><subject>RNA Analyses in Cells</subject><subject>RNA in Disease</subject><subject>RNA Interference - physiology</subject><subject>RNA, Small Interfering - administration & dosage</subject><subject>RNA-mediated interference</subject><subject>RNAi: Mechanisms of Action</subject><subject>Validation Studies as Topic</subject><issn>1757-7004</issn><issn>1757-7012</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM1PwjAchhujEYLEuwdD4sGDGbZd124XE4KKRoIJfuCt6UqrxcGwHSD_vUVwfiT20qZ98vzevgDsI9hEEOLThZ2IJsJboIpYxAIGEd4uz5BUQN25EfSLQMwQ2gUVjJIwihNSBQfnKjNzZZeNXDf6vZZpjNXQiCK3bg_saJE5Vd_sNfBweXHfvgq6t53rdqsbyCikOAiHlMaSpHgodCRSimOBdEK0vyFUpoIoKNKUIaq1lJSwRMbxkEQUaSaogCysgbO1dzpL_XCpJoUVGZ9aMxZ2yXNh-O-XiXnhz_mce2fi_-MFxxuBzd9myhV8bJxUWSYmKp85Hichwwgi4smjP-Qon_n2MscxhJSFNInht0_a3DmrdJkFQb5qnK8a5wh78vBn9JL76tcDJ2tgYTK1_M_DB775T12wpo0r1HtJC_vKfTYW8UGvw9t3FMU3j0-8H34AFyiXuw</recordid><startdate>201009</startdate><enddate>201009</enddate><creator>Ford, Lance P.</creator><creator>Toloue, Masoud M.</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201009</creationdate><title>Delivery of RNAi mediators</title><author>Ford, Lance P. ; Toloue, Masoud M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5362-3d668c4b2daf5ab628a1f94f4b246cba4e0abb716ffcc6479c88d4561f7a6a073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Clinical Trials as Topic</topic><topic>Drug Delivery Systems - methods</topic><topic>Drug Discovery - methods</topic><topic>Focus</topic><topic>Gene Transfer Techniques</topic><topic>Humans</topic><topic>Models, Animal</topic><topic>Polynucleotides</topic><topic>Ribonucleic acid</topic><topic>Riboswitches</topic><topic>RNA</topic><topic>RNA Analyses in Cells</topic><topic>RNA in Disease</topic><topic>RNA Interference - physiology</topic><topic>RNA, Small Interfering - administration & dosage</topic><topic>RNA-mediated interference</topic><topic>RNAi: Mechanisms of Action</topic><topic>Validation Studies as Topic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ford, Lance P.</creatorcontrib><creatorcontrib>Toloue, Masoud M.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Wiley interdisciplinary reviews. RNA</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ford, Lance P.</au><au>Toloue, Masoud M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Delivery of RNAi mediators</atitle><jtitle>Wiley interdisciplinary reviews. RNA</jtitle><addtitle>WIREs RNA</addtitle><date>2010-09</date><risdate>2010</risdate><volume>1</volume><issue>2</issue><spage>341</spage><epage>350</epage><pages>341-350</pages><issn>1757-7004</issn><eissn>1757-7012</eissn><abstract>Delivering polynucleotides into animals has been a major challenge facing their success as therapeutic agents. Given the matured understanding of antibody‐mediated delivery techniques, it is possible to rationally design delivery vehicles that circulate in the blood stream and are specifically delivered into target organs. If the targeting moiety is designed to contain the cargo of an RNAi mediator without impacting its paratope, directed delivery can be achieved. In this article, we review the state of art in delivery technology for RNA mediators and address how this technique could soon be used to enhance the efficacy of the numerous small RNA therapeutic programs currently under evaluation. Copyright © 2010 John Wiley & Sons, Ltd.
This article is categorized under:
Regulatory RNAs/RNAi/Riboswitches > RNAi: Mechanisms of Action
RNA Methods > RNA Analyses in Cells
RNA in Disease and Development > RNA in Disease</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>21935894</pmid><doi>10.1002/wrna.12</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1757-7004 |
| ispartof | Wiley interdisciplinary reviews. RNA, 2010-09, Vol.1 (2), p.341-350 |
| issn | 1757-7004 1757-7012 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7169711 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Clinical Trials as Topic Drug Delivery Systems - methods Drug Discovery - methods Focus Gene Transfer Techniques Humans Models, Animal Polynucleotides Ribonucleic acid Riboswitches RNA RNA Analyses in Cells RNA in Disease RNA Interference - physiology RNA, Small Interfering - administration & dosage RNA-mediated interference RNAi: Mechanisms of Action Validation Studies as Topic |
| title | Delivery of RNAi mediators |
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