Ligustrazine ameliorates lipopolysaccharide‑induced neurocognitive impairment by activating autophagy via the PI3K/AKT/mTOR pathway

Autophagy is a lysosome‑mediated cell content‑dependent degradation pathway that leads to enhanced inflammation in an uncontrolled state. This study examined the role of autophagy in lipopolysaccharide (LPS)‑induced brain inflammation and the effects of the traditional Chinese medicine ligustrazine...

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Veröffentlicht in:	International journal of molecular medicine 2020-06, Vol.45 (6), p.1711-1720
Hauptverfasser:	Li, Guangming, Liu, Sisi, Wang, Huili, Pan, Rui, Tang, Haijie, Yan, Xueqin, Wang, Yanping, Fu, Yongmei, Jing, Fujun, Dong, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Alzheimer's disease Analysis Animal memory Animals Apoptosis - drug effects Asian medicine Autophagy Autophagy - drug effects Disabilities Down-Regulation - drug effects Experiments Female Inflammation Inflammation - drug therapy Inflammation - metabolism Interleukin-1beta - metabolism Interleukins Lipopolysaccharides - pharmacology Male Mitogens Necrosis Neurocognitive Disorders - chemically induced Neurocognitive Disorders - drug therapy Neurocognitive Disorders - metabolism Neurons Older people Phosphatidylinositol 3-Kinases - metabolism Protein kinases Proto-Oncogene Proteins c-akt - metabolism Pyrazines - pharmacology Rats Rats, Sprague-Dawley Signal Transduction - drug effects TOR Serine-Threonine Kinases - metabolism Traditional Chinese medicine Tumor necrosis factor Tumor necrosis factor-TNF Tumors
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