ATAC-Me Captures Prolonged DNA Methylation of Dynamic Chromatin Accessibility Loci during Cell Fate Transitions

DNA methylation of enhancers is dynamic, cell-type specific, and vital for cell fate progression. However, current models inadequately define its role within the hierarchy of gene regulation. Analysis of independent datasets shows an unanticipated overlap between DNA methylation and chromatin access...

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Veröffentlicht in:	Molecular cell 2020-03, Vol.77 (6), p.1350-1364.e6
Hauptverfasser:	Barnett, Kelly R., Decato, Benjamin E., Scott, Timothy J., Hansen, Tyler J., Chen, Bob, Attalla, Jonathan, Smith, Andrew D., Hodges, Emily
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Cell Differentiation Cell Lineage cellular differentiation Cellular Reprogramming Chromatin - genetics chromatin accessibility DNA Methylation enhancers epigenetics Gene Expression Regulation, Developmental Gene Regulatory Networks High-Throughput Nucleotide Sequencing - methods Humans Macrophages - cytology Macrophages - metabolism Monocytes - cytology Monocytes - metabolism Regulatory Sequences, Nucleic Acid
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