RNA sequencing reveals novel macrophage transcriptome favoring neurovascular plasticity after ischemic stroke

Blood monocytes/macrophages infiltrate the brain after ischemic stroke and critically influence brain injury and regeneration. We investigated stroke-induced transcriptomic changes of monocytes/macrophages by RNA sequencing profiling, using a mouse model of permanent focal cerebral ischemia. Compare...

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Veröffentlicht in:	Journal of cerebral blood flow and metabolism 2020-04, Vol.40 (4), p.720-738
Hauptverfasser:	Wang, Rongrong, Liu, Yaan, Ye, Qing, Hassan, Sulaiman H, Zhao, Jingyan, Li, Sicheng, Hu, Xiaoming, Leak, Rehana K, Rocha, Marcelo, Wechsler, Lawrence R, Chen, Jun, Shi, Yejie
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - blood supply Brain - metabolism Cell Movement - genetics Cerebrovascular Circulation - genetics Ischemic Stroke - blood Ischemic Stroke - genetics Macrophages - metabolism Mice, Inbred C57BL Mice, Knockout Monocytes - metabolism Neovascularization, Physiologic - genetics Neurogenesis - genetics Neuronal Plasticity - genetics Original PPAR gamma - genetics Sequence Analysis, RNA Transcriptome - genetics
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