Silencing the lncRNA Maclpil in pro-inflammatory macrophages attenuates acute experimental ischemic stroke via LCP1 in mice

Long noncoding RNAs (lncRNA) expression profiles change in the ischemic brain after stroke, but their roles in specific cell types after stroke have not been studied. We tested the hypothesis that lncRNA modulates brain injury by altering macrophage functions. Using RNA deep sequencing, we identifie...

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Veröffentlicht in:	Journal of cerebral blood flow and metabolism 2020-04, Vol.40 (4), p.747-759
Hauptverfasser:	Wang, Yan, Luo, Ying, Yao, Yang, Ji, Yuhua, Feng, Liangshu, Du, Fang, Zheng, Xiaoya, Tao, Tao, Zhai, Xuan, Li, Yaning, Han, Pei, Xu, Baohui, Zhao, Heng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Cell Movement - genetics Cell Movement - immunology Disease Models, Animal Down-Regulation Gene Silencing Inflammation Ischemic Stroke - genetics Ischemic Stroke - immunology Macrophages - immunology Macrophages - metabolism Male Mice, Inbred C57BL Microfilament Proteins - antagonists & inhibitors Microfilament Proteins - genetics Microglia - immunology Microglia - metabolism Monocytes - immunology Monocytes - metabolism Original Phagocytosis - genetics Phagocytosis - immunology RNA, Long Noncoding - genetics
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