Triglyceride/High-Density Lipoprotein Cholesterol Ratio Is Associated with In-Hospital Mortality in Acute Type B Aortic Dissection
Background. Triglyceride/high-density lipoprotein cholesterol (TG/HDL-c) ratio varies with vascular and other metabolic diseases. However, its role in acute type B aortic dissection is not well understood. In the current study, we evaluated the relationship between TG/HDL-c ratio and in-hospital mor...
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| description | Background. Triglyceride/high-density lipoprotein cholesterol (TG/HDL-c) ratio varies with vascular and other metabolic diseases. However, its role in acute type B aortic dissection is not well understood. In the current study, we evaluated the relationship between TG/HDL-c ratio and in-hospital mortality in type B aortic dissection. Methods. We performed a retrospective analysis of consecutive patients between January 2015 and December 2018, by targeting dependent (TG/HDL-c ratio) and independent (in-hospital mortality) variables. TG/HDL-c ratio was determined as a division of TG levels by HDL-c levels. Results. Of 523 patients in the study, we found a mean age of 55.00±11.74 years, 15.68% of them being female. A fully-adjusted model revealed a positive relationship between TG/HDL-c ratio and in-hospital mortality in acute type B aortic dissection after adjusting confounders (OR=2.08, 95% CI 1.32 to 3.27). This relationship was also nonlinear, with a point of 2.05. OR values (and confidence intervals) for the right (>2.05) and left (≤2.05) sides of the inflection point were 1.0 (0.580-1.26, P=0.983) and 3.17 (1.54-6.57, P=0.001), respectively. Conclusions. The TG/HDL-c ratio and in-hospital mortality in type B AAD have a nonlinear relationship among Chinese population. This ratio increased in-hospital mortality when it is less than 2.05. |
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Triglyceride/high-density lipoprotein cholesterol (TG/HDL-c) ratio varies with vascular and other metabolic diseases. However, its role in acute type B aortic dissection is not well understood. In the current study, we evaluated the relationship between TG/HDL-c ratio and in-hospital mortality in type B aortic dissection. Methods. We performed a retrospective analysis of consecutive patients between January 2015 and December 2018, by targeting dependent (TG/HDL-c ratio) and independent (in-hospital mortality) variables. TG/HDL-c ratio was determined as a division of TG levels by HDL-c levels. Results. Of 523 patients in the study, we found a mean age of 55.00±11.74 years, 15.68% of them being female. A fully-adjusted model revealed a positive relationship between TG/HDL-c ratio and in-hospital mortality in acute type B aortic dissection after adjusting confounders (OR=2.08, 95% CI 1.32 to 3.27). This relationship was also nonlinear, with a point of 2.05. OR values (and confidence intervals) for the right (>2.05) and left (≤2.05) sides of the inflection point were 1.0 (0.580-1.26, P=0.983) and 3.17 (1.54-6.57, P=0.001), respectively. Conclusions. The TG/HDL-c ratio and in-hospital mortality in type B AAD have a nonlinear relationship among Chinese population. This ratio increased in-hospital mortality when it is less than 2.05.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2020/5419846</identifier><identifier>PMID: 32337256</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Adult ; Age ; Aged ; Alanine Transaminase - blood ; Analysis ; Aneurysm, Dissecting - blood ; Aneurysm, Dissecting - mortality ; Aorta ; Aortic dissection ; Asians ; Aspartate Aminotransferases - blood ; Atherosclerosis ; Blood pressure ; Body Mass Index ; Cardiovascular disease ; China ; Cholesterol ; Cholesterol, HDL - blood ; Confidence intervals ; Creatinine - blood ; Density ; Diabetes ; Dissecting aneurysm ; Dissection ; Female ; Hemoglobin ; High density lipoprotein ; Hospital Mortality ; Hospitals ; Humans ; Hypertension ; Independent variables ; Lipoproteins ; Male ; Marfan syndrome ; Medical research ; Medicine, Experimental ; Metabolic disorders ; Metabolic syndrome ; Middle Aged ; Mortality ; Patient outcomes ; Regression analysis ; Retrospective Studies ; Risk Factors ; Stroke ; Studies ; Surgery ; Triglycerides ; Triglycerides - blood ; Troponin T - blood ; Uric acid ; Uric Acid - blood ; Variables</subject><ispartof>BioMed research international, 2020, Vol.2020 (2020), p.1-9</ispartof><rights>Copyright © 2020 Yang Zhou et al.</rights><rights>COPYRIGHT 2020 John Wiley & Sons, Inc.</rights><rights>Copyright © 2020 Yang Zhou et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2020 Yang Zhou et al. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-cc752846dc3c9f40e8b899582257b0ddb9d9c55396f5f1e1989f9ed80dd4e0f73</citedby><cites>FETCH-LOGICAL-c499t-cc752846dc3c9f40e8b899582257b0ddb9d9c55396f5f1e1989f9ed80dd4e0f73</cites><orcidid>0000-0003-4809-0175 ; 0000-0003-1753-6795 ; 0000-0002-3575-2646 ; 0000-0001-7373-1996 ; 0000-0003-3897-6773 ; 0000-0003-1067-9822</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168694/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168694/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,4010,27900,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32337256$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Uehara, Yoshinari</contributor><creatorcontrib>Peng, Wen</creatorcontrib><creatorcontrib>Pan, Xiaogao</creatorcontrib><creatorcontrib>He, Huaping</creatorcontrib><creatorcontrib>Yang, Guifang</creatorcontrib><creatorcontrib>Zhou, Yang</creatorcontrib><creatorcontrib>Chai, Xiangping</creatorcontrib><title>Triglyceride/High-Density Lipoprotein Cholesterol Ratio Is Associated with In-Hospital Mortality in Acute Type B Aortic Dissection</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Background. Triglyceride/high-density lipoprotein cholesterol (TG/HDL-c) ratio varies with vascular and other metabolic diseases. However, its role in acute type B aortic dissection is not well understood. In the current study, we evaluated the relationship between TG/HDL-c ratio and in-hospital mortality in type B aortic dissection. Methods. We performed a retrospective analysis of consecutive patients between January 2015 and December 2018, by targeting dependent (TG/HDL-c ratio) and independent (in-hospital mortality) variables. TG/HDL-c ratio was determined as a division of TG levels by HDL-c levels. Results. Of 523 patients in the study, we found a mean age of 55.00±11.74 years, 15.68% of them being female. A fully-adjusted model revealed a positive relationship between TG/HDL-c ratio and in-hospital mortality in acute type B aortic dissection after adjusting confounders (OR=2.08, 95% CI 1.32 to 3.27). This relationship was also nonlinear, with a point of 2.05. OR values (and confidence intervals) for the right (>2.05) and left (≤2.05) sides of the inflection point were 1.0 (0.580-1.26, P=0.983) and 3.17 (1.54-6.57, P=0.001), respectively. Conclusions. The TG/HDL-c ratio and in-hospital mortality in type B AAD have a nonlinear relationship among Chinese population. This ratio increased in-hospital mortality when it is less than 2.05.</description><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Alanine Transaminase - blood</subject><subject>Analysis</subject><subject>Aneurysm, Dissecting - blood</subject><subject>Aneurysm, Dissecting - mortality</subject><subject>Aorta</subject><subject>Aortic dissection</subject><subject>Asians</subject><subject>Aspartate Aminotransferases - blood</subject><subject>Atherosclerosis</subject><subject>Blood pressure</subject><subject>Body Mass Index</subject><subject>Cardiovascular disease</subject><subject>China</subject><subject>Cholesterol</subject><subject>Cholesterol, HDL - blood</subject><subject>Confidence intervals</subject><subject>Creatinine - blood</subject><subject>Density</subject><subject>Diabetes</subject><subject>Dissecting aneurysm</subject><subject>Dissection</subject><subject>Female</subject><subject>Hemoglobin</subject><subject>High density lipoprotein</subject><subject>Hospital Mortality</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Independent variables</subject><subject>Lipoproteins</subject><subject>Male</subject><subject>Marfan syndrome</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Metabolic disorders</subject><subject>Metabolic syndrome</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Patient outcomes</subject><subject>Regression analysis</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Stroke</subject><subject>Studies</subject><subject>Surgery</subject><subject>Triglycerides</subject><subject>Triglycerides - blood</subject><subject>Troponin T - blood</subject><subject>Uric acid</subject><subject>Uric Acid - blood</subject><subject>Variables</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkkGP0zAQhSMEYlfL3jgjS1yQIDS2Yye-IIXuLq1UhITK2XKdSetVagfbYdUrvxxHLWXhhC9jaT6_mTeeLHuJi_cYMzYjBSlmrMSiLvmT7JJQXOYcl_jp-U7pRXYdwn2RTo15Ifjz7IISSivC-GX2c-3Ntj9o8KaF2cJsd_kN2GDiAa3M4AbvIhiL5jvXQ4jgXY--qmgcWgbUhOC0URFa9GDiDi1tvnBhMFH16LPzKUwy6XWjxwhofRgAfURNyhiNbkwIoJOSfZE961Qf4PoUr7Jvd7fr-SJfffm0nDerXJdCxFzripFks9VUi64soN7UQrCaEFZtirbdiFZoxqjgHeswpJGITkBbp1QJRVfRq-zDUXcYN3toNdjoVS8Hb_bKH6RTRv6dsWYnt-6HrDCvuSiTwJuTgHffxzQOuTdBQ98rC24MklDBUjOpckJf_4Peu9HbZG-icF1x_pjaqh6ksZ1LdfUkKhtOGKHJzUS9O1LauxA8dOeWcSGnLZDTFsjTFiT81WObZ_j3nyfg7RHYGduqB_OfcpAY6NQfGtOyYhX9Bd7KxB8</recordid><startdate>2020</startdate><enddate>2020</enddate><creator>Peng, Wen</creator><creator>Pan, Xiaogao</creator><creator>He, Huaping</creator><creator>Yang, Guifang</creator><creator>Zhou, Yang</creator><creator>Chai, Xiangping</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PIMPY</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4809-0175</orcidid><orcidid>https://orcid.org/0000-0003-1753-6795</orcidid><orcidid>https://orcid.org/0000-0002-3575-2646</orcidid><orcidid>https://orcid.org/0000-0001-7373-1996</orcidid><orcidid>https://orcid.org/0000-0003-3897-6773</orcidid><orcidid>https://orcid.org/0000-0003-1067-9822</orcidid></search><sort><creationdate>2020</creationdate><title>Triglyceride/High-Density Lipoprotein Cholesterol Ratio Is Associated with In-Hospital Mortality in Acute Type B Aortic Dissection</title><author>Peng, Wen ; Pan, Xiaogao ; He, Huaping ; Yang, Guifang ; Zhou, Yang ; Chai, Xiangping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-cc752846dc3c9f40e8b899582257b0ddb9d9c55396f5f1e1989f9ed80dd4e0f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Alanine Transaminase - blood</topic><topic>Analysis</topic><topic>Aneurysm, Dissecting - blood</topic><topic>Aneurysm, Dissecting - mortality</topic><topic>Aorta</topic><topic>Aortic dissection</topic><topic>Asians</topic><topic>Aspartate Aminotransferases - blood</topic><topic>Atherosclerosis</topic><topic>Blood pressure</topic><topic>Body Mass Index</topic><topic>Cardiovascular disease</topic><topic>China</topic><topic>Cholesterol</topic><topic>Cholesterol, HDL - blood</topic><topic>Confidence intervals</topic><topic>Creatinine - blood</topic><topic>Density</topic><topic>Diabetes</topic><topic>Dissecting aneurysm</topic><topic>Dissection</topic><topic>Female</topic><topic>Hemoglobin</topic><topic>High density lipoprotein</topic><topic>Hospital Mortality</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Independent variables</topic><topic>Lipoproteins</topic><topic>Male</topic><topic>Marfan syndrome</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Metabolic disorders</topic><topic>Metabolic syndrome</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Patient outcomes</topic><topic>Regression analysis</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Stroke</topic><topic>Studies</topic><topic>Surgery</topic><topic>Triglycerides</topic><topic>Triglycerides - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Peng, Wen</au><au>Pan, Xiaogao</au><au>He, Huaping</au><au>Yang, Guifang</au><au>Zhou, Yang</au><au>Chai, Xiangping</au><au>Uehara, Yoshinari</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Triglyceride/High-Density Lipoprotein Cholesterol Ratio Is Associated with In-Hospital Mortality in Acute Type B Aortic Dissection</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2020</date><risdate>2020</risdate><volume>2020</volume><issue>2020</issue><spage>1</spage><epage>9</epage><pages>1-9</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Background. Triglyceride/high-density lipoprotein cholesterol (TG/HDL-c) ratio varies with vascular and other metabolic diseases. However, its role in acute type B aortic dissection is not well understood. In the current study, we evaluated the relationship between TG/HDL-c ratio and in-hospital mortality in type B aortic dissection. Methods. We performed a retrospective analysis of consecutive patients between January 2015 and December 2018, by targeting dependent (TG/HDL-c ratio) and independent (in-hospital mortality) variables. TG/HDL-c ratio was determined as a division of TG levels by HDL-c levels. Results. Of 523 patients in the study, we found a mean age of 55.00±11.74 years, 15.68% of them being female. A fully-adjusted model revealed a positive relationship between TG/HDL-c ratio and in-hospital mortality in acute type B aortic dissection after adjusting confounders (OR=2.08, 95% CI 1.32 to 3.27). This relationship was also nonlinear, with a point of 2.05. OR values (and confidence intervals) for the right (>2.05) and left (≤2.05) sides of the inflection point were 1.0 (0.580-1.26, P=0.983) and 3.17 (1.54-6.57, P=0.001), respectively. Conclusions. The TG/HDL-c ratio and in-hospital mortality in type B AAD have a nonlinear relationship among Chinese population. This ratio increased in-hospital mortality when it is less than 2.05.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>32337256</pmid><doi>10.1155/2020/5419846</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-4809-0175</orcidid><orcidid>https://orcid.org/0000-0003-1753-6795</orcidid><orcidid>https://orcid.org/0000-0002-3575-2646</orcidid><orcidid>https://orcid.org/0000-0001-7373-1996</orcidid><orcidid>https://orcid.org/0000-0003-3897-6773</orcidid><orcidid>https://orcid.org/0000-0003-1067-9822</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Age Aged Alanine Transaminase - blood Analysis Aneurysm, Dissecting - blood Aneurysm, Dissecting - mortality Aorta Aortic dissection Asians Aspartate Aminotransferases - blood Atherosclerosis Blood pressure Body Mass Index Cardiovascular disease China Cholesterol Cholesterol, HDL - blood Confidence intervals Creatinine - blood Density Diabetes Dissecting aneurysm Dissection Female Hemoglobin High density lipoprotein Hospital Mortality Hospitals Humans Hypertension Independent variables Lipoproteins Male Marfan syndrome Medical research Medicine, Experimental Metabolic disorders Metabolic syndrome Middle Aged Mortality Patient outcomes Regression analysis Retrospective Studies Risk Factors Stroke Studies Surgery Triglycerides Triglycerides - blood Troponin T - blood Uric acid Uric Acid - blood Variables |
| title | Triglyceride/High-Density Lipoprotein Cholesterol Ratio Is Associated with In-Hospital Mortality in Acute Type B Aortic Dissection |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-19T13%3A43%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Triglyceride/High-Density%20Lipoprotein%20Cholesterol%20Ratio%20Is%20Associated%20with%20In-Hospital%20Mortality%20in%20Acute%20Type%20B%20Aortic%20Dissection&rft.jtitle=BioMed%20research%20international&rft.au=Peng,%20Wen&rft.date=2020&rft.volume=2020&rft.issue=2020&rft.spage=1&rft.epage=9&rft.pages=1-9&rft.issn=2314-6133&rft.eissn=2314-6141&rft_id=info:doi/10.1155/2020/5419846&rft_dat=%3Cgale_pubme%3EA625235398%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2391876698&rft_id=info:pmid/32337256&rft_galeid=A625235398&rfr_iscdi=true |