Flavivirus induces MHC antigen on human myoblasts: A model of autoimmune myositis?

Infection of human embryonic myoblasts by West Nile virus (WNV), a flavivirus, caused significant upregulation of class I and II MHC expression as determined by flow cytometry. After 48 hours at a multiplicity of infection of 5 pfu/cell, a sixfold increase in MHC class I expression was induced from...

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Veröffentlicht in:	Muscle & nerve 1992-11, Vol.15 (11), p.1271-1277
Hauptverfasser:	Bao, Shisan, King, Nicholas J. C., Dos Remedios, Cristobal G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Autoimmune Diseases - immunology autoimmunity Embryo, Mammalian - cytology Embryo, Mammalian - immunology flavivirus Flow Cytometry HLA Antigens - immunology Humans major histocompatibility complex Muscles - cytology Muscles - embryology Muscles - immunology myoblasts myositis Myositis - immunology West Nile Fever - diagnosis West Nile Fever - immunology West Nile virus - immunology
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