Sero‐prevalence of Middle East respiratory syndrome coronavirus (MERS‐CoV) specific antibodies in dromedary camels in Tabuk, Saudi Arabia
The Middle East Respiratory Syndrome Coronavirus (MERS‐CoV) is a novel Coronavirus which was responsible of the first case of human acute respiratory syndrome in the Kingdom of Saudi Arabia (KSA), 2012. Dromedary camels are considered as potential reservoirs for the virus and seem to be the only ani...
Gespeichert in:
| Veröffentlicht in: | Journal of medical virology 2018-08, Vol.90 (8), p.1285-1289 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1289 |
|---|---|
| container_issue | 8 |
| container_start_page | 1285 |
| container_title | Journal of medical virology |
| container_volume | 90 |
| creator | Harrath, Rafik Abu Duhier, Faisel M. |
| description | The Middle East Respiratory Syndrome Coronavirus (MERS‐CoV) is a novel Coronavirus which was responsible of the first case of human acute respiratory syndrome in the Kingdom of Saudi Arabia (KSA), 2012. Dromedary camels are considered as potential reservoirs for the virus and seem to be the only animal host which may transmit the infection to human. Further studies are required to better understand the animal sources of zoonotic transmission route and the risks of this infection. A primary sero‐prevalence study of MERS‐CoV preexisting neutralizing antibodies in Dromedary camel serum was conducted in Tabuk, western north region of KSA, in order to assess the seopositivity of these animals and to explain their possible role in the transmission of the infection to Human. One hundred seventy one (171) serum samples were collected from healthy dromedary camels with different ages and genders in Tabuk city and tested for specific serum IgG by ELISA using the receptor‐binding S1 subunits of spike proteins of MERS‐CoV. 144 (84,21%) of the total camel sera shown the presence of protein‐specific antibodies against MERS‐CoV. These results may provide evidence that MERS‐CoV has previously infected dromedary camels in Tabuk and may support the possible role of camels in the human infection. |
| doi_str_mv | 10.1002/jmv.25186 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7166535</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2026415099</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4436-f3b9abaf7088f99dcf3facbe69cb026837c39f8174d3652cc07a8003c9b5426a3</originalsourceid><addsrcrecordid>eNp1kd9qFDEYR4NY7Fq98AUk4E0LTps_M5nJjVCWVStdBLf2NnyTSTTrzGRMZlb2zhcQfEafpOluLSp4FZicOZzwQ-gZJaeUEHa27janrKCVeIBmlEiRSVLSh2hGaC4yIWhxiB7HuCaEVJKxR-iQSSF4zuUM_ViZ4H99_zkEs4HW9Npgb_HSNU1r8ALiiIOJgwsw-rDFcds3wXcGax98DxsXpoiPl4sPq6SY--sTHAejnXUaQz-62jfOROx6vPurgaTQ0Jl29-0K6unLS7yCqXH4PEDt4Ak6sNBG8_TuPEIfXy-u5m-zy_dvLubnl5nOcy4yy2sJNdiSVJWVstGWW9C1EVLXhImKl5pLW9Eyb7gomNakhIoQrmVd5EwAP0Kv9t5hqlOXNv0YoFVDcF1qVB6c-vumd5_VJ79RJRWi4EUSHN8Jgv86mTiqzkVt2hZ646eoWMrIaUGkTOiLf9C1n0KfnpeookyROakSdbKndPAxBmPvYyhRtyOrNLLajZzY53_W35O_V03A2R745lqz_b9JvVte75U3sT-1Wg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2057174408</pqid></control><display><type>article</type><title>Sero‐prevalence of Middle East respiratory syndrome coronavirus (MERS‐CoV) specific antibodies in dromedary camels in Tabuk, Saudi Arabia</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Harrath, Rafik ; Abu Duhier, Faisel M.</creator><creatorcontrib>Harrath, Rafik ; Abu Duhier, Faisel M.</creatorcontrib><description>The Middle East Respiratory Syndrome Coronavirus (MERS‐CoV) is a novel Coronavirus which was responsible of the first case of human acute respiratory syndrome in the Kingdom of Saudi Arabia (KSA), 2012. Dromedary camels are considered as potential reservoirs for the virus and seem to be the only animal host which may transmit the infection to human. Further studies are required to better understand the animal sources of zoonotic transmission route and the risks of this infection. A primary sero‐prevalence study of MERS‐CoV preexisting neutralizing antibodies in Dromedary camel serum was conducted in Tabuk, western north region of KSA, in order to assess the seopositivity of these animals and to explain their possible role in the transmission of the infection to Human. One hundred seventy one (171) serum samples were collected from healthy dromedary camels with different ages and genders in Tabuk city and tested for specific serum IgG by ELISA using the receptor‐binding S1 subunits of spike proteins of MERS‐CoV. 144 (84,21%) of the total camel sera shown the presence of protein‐specific antibodies against MERS‐CoV. These results may provide evidence that MERS‐CoV has previously infected dromedary camels in Tabuk and may support the possible role of camels in the human infection.</description><identifier>ISSN: 0146-6615</identifier><identifier>EISSN: 1096-9071</identifier><identifier>DOI: 10.1002/jmv.25186</identifier><identifier>PMID: 29663439</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Animals ; Antibodies ; Antibodies, Viral - blood ; blood ; Camelidae ; Camels ; Camelus ; Camelus dromedarius ; Coronaviridae ; Coronavirus ; Coronavirus Infections - epidemiology ; Coronavirus Infections - veterinary ; Coronaviruses ; enzyme assays ; Enzyme-Linked Immunosorbent Assay ; Female ; Health risks ; immunoglobulin ; Immunoglobulin G ; Immunoglobulin G - blood ; Immunoglobulins ; Infections ; Male ; Middle East Respiratory Syndrome Coronavirus - immunology ; Proteins ; reservoir ; Respiratory diseases ; Saudi Arabia - epidemiology ; Seroepidemiologic Studies ; Spike Glycoprotein, Coronavirus - immunology ; Virology ; Viruses</subject><ispartof>Journal of medical virology, 2018-08, Vol.90 (8), p.1285-1289</ispartof><rights>2018 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4436-f3b9abaf7088f99dcf3facbe69cb026837c39f8174d3652cc07a8003c9b5426a3</citedby><cites>FETCH-LOGICAL-c4436-f3b9abaf7088f99dcf3facbe69cb026837c39f8174d3652cc07a8003c9b5426a3</cites><orcidid>0000-0002-9071-2970</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmv.25186$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmv.25186$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29663439$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Harrath, Rafik</creatorcontrib><creatorcontrib>Abu Duhier, Faisel M.</creatorcontrib><title>Sero‐prevalence of Middle East respiratory syndrome coronavirus (MERS‐CoV) specific antibodies in dromedary camels in Tabuk, Saudi Arabia</title><title>Journal of medical virology</title><addtitle>J Med Virol</addtitle><description>The Middle East Respiratory Syndrome Coronavirus (MERS‐CoV) is a novel Coronavirus which was responsible of the first case of human acute respiratory syndrome in the Kingdom of Saudi Arabia (KSA), 2012. Dromedary camels are considered as potential reservoirs for the virus and seem to be the only animal host which may transmit the infection to human. Further studies are required to better understand the animal sources of zoonotic transmission route and the risks of this infection. A primary sero‐prevalence study of MERS‐CoV preexisting neutralizing antibodies in Dromedary camel serum was conducted in Tabuk, western north region of KSA, in order to assess the seopositivity of these animals and to explain their possible role in the transmission of the infection to Human. One hundred seventy one (171) serum samples were collected from healthy dromedary camels with different ages and genders in Tabuk city and tested for specific serum IgG by ELISA using the receptor‐binding S1 subunits of spike proteins of MERS‐CoV. 144 (84,21%) of the total camel sera shown the presence of protein‐specific antibodies against MERS‐CoV. These results may provide evidence that MERS‐CoV has previously infected dromedary camels in Tabuk and may support the possible role of camels in the human infection.</description><subject>Animals</subject><subject>Antibodies</subject><subject>Antibodies, Viral - blood</subject><subject>blood</subject><subject>Camelidae</subject><subject>Camels</subject><subject>Camelus</subject><subject>Camelus dromedarius</subject><subject>Coronaviridae</subject><subject>Coronavirus</subject><subject>Coronavirus Infections - epidemiology</subject><subject>Coronavirus Infections - veterinary</subject><subject>Coronaviruses</subject><subject>enzyme assays</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Health risks</subject><subject>immunoglobulin</subject><subject>Immunoglobulin G</subject><subject>Immunoglobulin G - blood</subject><subject>Immunoglobulins</subject><subject>Infections</subject><subject>Male</subject><subject>Middle East Respiratory Syndrome Coronavirus - immunology</subject><subject>Proteins</subject><subject>reservoir</subject><subject>Respiratory diseases</subject><subject>Saudi Arabia - epidemiology</subject><subject>Seroepidemiologic Studies</subject><subject>Spike Glycoprotein, Coronavirus - immunology</subject><subject>Virology</subject><subject>Viruses</subject><issn>0146-6615</issn><issn>1096-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kd9qFDEYR4NY7Fq98AUk4E0LTps_M5nJjVCWVStdBLf2NnyTSTTrzGRMZlb2zhcQfEafpOluLSp4FZicOZzwQ-gZJaeUEHa27janrKCVeIBmlEiRSVLSh2hGaC4yIWhxiB7HuCaEVJKxR-iQSSF4zuUM_ViZ4H99_zkEs4HW9Npgb_HSNU1r8ALiiIOJgwsw-rDFcds3wXcGax98DxsXpoiPl4sPq6SY--sTHAejnXUaQz-62jfOROx6vPurgaTQ0Jl29-0K6unLS7yCqXH4PEDt4Ak6sNBG8_TuPEIfXy-u5m-zy_dvLubnl5nOcy4yy2sJNdiSVJWVstGWW9C1EVLXhImKl5pLW9Eyb7gomNakhIoQrmVd5EwAP0Kv9t5hqlOXNv0YoFVDcF1qVB6c-vumd5_VJ79RJRWi4EUSHN8Jgv86mTiqzkVt2hZ646eoWMrIaUGkTOiLf9C1n0KfnpeookyROakSdbKndPAxBmPvYyhRtyOrNLLajZzY53_W35O_V03A2R745lqz_b9JvVte75U3sT-1Wg</recordid><startdate>201808</startdate><enddate>201808</enddate><creator>Harrath, Rafik</creator><creator>Abu Duhier, Faisel M.</creator><general>Wiley Subscription Services, Inc</general><general>John Wiley and Sons Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9071-2970</orcidid></search><sort><creationdate>201808</creationdate><title>Sero‐prevalence of Middle East respiratory syndrome coronavirus (MERS‐CoV) specific antibodies in dromedary camels in Tabuk, Saudi Arabia</title><author>Harrath, Rafik ; Abu Duhier, Faisel M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4436-f3b9abaf7088f99dcf3facbe69cb026837c39f8174d3652cc07a8003c9b5426a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Antibodies</topic><topic>Antibodies, Viral - blood</topic><topic>blood</topic><topic>Camelidae</topic><topic>Camels</topic><topic>Camelus</topic><topic>Camelus dromedarius</topic><topic>Coronaviridae</topic><topic>Coronavirus</topic><topic>Coronavirus Infections - epidemiology</topic><topic>Coronavirus Infections - veterinary</topic><topic>Coronaviruses</topic><topic>enzyme assays</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Health risks</topic><topic>immunoglobulin</topic><topic>Immunoglobulin G</topic><topic>Immunoglobulin G - blood</topic><topic>Immunoglobulins</topic><topic>Infections</topic><topic>Male</topic><topic>Middle East Respiratory Syndrome Coronavirus - immunology</topic><topic>Proteins</topic><topic>reservoir</topic><topic>Respiratory diseases</topic><topic>Saudi Arabia - epidemiology</topic><topic>Seroepidemiologic Studies</topic><topic>Spike Glycoprotein, Coronavirus - immunology</topic><topic>Virology</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Harrath, Rafik</creatorcontrib><creatorcontrib>Abu Duhier, Faisel M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of medical virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Harrath, Rafik</au><au>Abu Duhier, Faisel M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sero‐prevalence of Middle East respiratory syndrome coronavirus (MERS‐CoV) specific antibodies in dromedary camels in Tabuk, Saudi Arabia</atitle><jtitle>Journal of medical virology</jtitle><addtitle>J Med Virol</addtitle><date>2018-08</date><risdate>2018</risdate><volume>90</volume><issue>8</issue><spage>1285</spage><epage>1289</epage><pages>1285-1289</pages><issn>0146-6615</issn><eissn>1096-9071</eissn><abstract>The Middle East Respiratory Syndrome Coronavirus (MERS‐CoV) is a novel Coronavirus which was responsible of the first case of human acute respiratory syndrome in the Kingdom of Saudi Arabia (KSA), 2012. Dromedary camels are considered as potential reservoirs for the virus and seem to be the only animal host which may transmit the infection to human. Further studies are required to better understand the animal sources of zoonotic transmission route and the risks of this infection. A primary sero‐prevalence study of MERS‐CoV preexisting neutralizing antibodies in Dromedary camel serum was conducted in Tabuk, western north region of KSA, in order to assess the seopositivity of these animals and to explain their possible role in the transmission of the infection to Human. One hundred seventy one (171) serum samples were collected from healthy dromedary camels with different ages and genders in Tabuk city and tested for specific serum IgG by ELISA using the receptor‐binding S1 subunits of spike proteins of MERS‐CoV. 144 (84,21%) of the total camel sera shown the presence of protein‐specific antibodies against MERS‐CoV. These results may provide evidence that MERS‐CoV has previously infected dromedary camels in Tabuk and may support the possible role of camels in the human infection.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29663439</pmid><doi>10.1002/jmv.25186</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-9071-2970</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0146-6615 |
| ispartof | Journal of medical virology, 2018-08, Vol.90 (8), p.1285-1289 |
| issn | 0146-6615 1096-9071 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7166535 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Antibodies Antibodies, Viral - blood blood Camelidae Camels Camelus Camelus dromedarius Coronaviridae Coronavirus Coronavirus Infections - epidemiology Coronavirus Infections - veterinary Coronaviruses enzyme assays Enzyme-Linked Immunosorbent Assay Female Health risks immunoglobulin Immunoglobulin G Immunoglobulin G - blood Immunoglobulins Infections Male Middle East Respiratory Syndrome Coronavirus - immunology Proteins reservoir Respiratory diseases Saudi Arabia - epidemiology Seroepidemiologic Studies Spike Glycoprotein, Coronavirus - immunology Virology Viruses |
| title | Sero‐prevalence of Middle East respiratory syndrome coronavirus (MERS‐CoV) specific antibodies in dromedary camels in Tabuk, Saudi Arabia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T01%3A54%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Sero%E2%80%90prevalence%20of%20Middle%20East%20respiratory%20syndrome%20coronavirus%20(MERS%E2%80%90CoV)%20specific%20antibodies%20in%20dromedary%20camels%20in%20Tabuk,%20Saudi%20Arabia&rft.jtitle=Journal%20of%20medical%20virology&rft.au=Harrath,%20Rafik&rft.date=2018-08&rft.volume=90&rft.issue=8&rft.spage=1285&rft.epage=1289&rft.pages=1285-1289&rft.issn=0146-6615&rft.eissn=1096-9071&rft_id=info:doi/10.1002/jmv.25186&rft_dat=%3Cproquest_pubme%3E2026415099%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2057174408&rft_id=info:pmid/29663439&rfr_iscdi=true |