Stepwise Promoter Melting by Bacterial RNA Polymerase

Transcription initiation requires formation of the open promoter complex (RPo). To generate RPo, RNA polymerase (RNAP) unwinds the DNA duplex to form the transcription bubble and loads the DNA into the RNAP active site. RPo formation is a multi-step process with transient intermediates of unknown st...

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Veröffentlicht in:	Molecular cell 2020-04, Vol.78 (2), p.275-288.e6
Hauptverfasser:	Chen, James, Chiu, Courtney, Gopalkrishnan, Saumya, Chen, Albert Y., Olinares, Paul Dominic B., Saecker, Ruth M., Winkelman, Jared T., Maloney, Michael F., Chait, Brian T., Ross, Wilma, Gourse, Richard L., Campbell, Elizabeth A., Darst, Seth A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Conformational change Cryoelectron Microscopy DNA DNA-Directed RNA Polymerases - chemistry DNA-Directed RNA Polymerases - genetics Escherichia coli - genetics Nucleic Acid Conformation Open promoter complex formation Promoter DNA Promoter Regions, Genetic - genetics Protein Binding - genetics Protein Conformation RNA polymerase RNA, Bacterial - genetics Transcription initiation Transcription Initiation, Genetic TraR
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