Targeted delivery of ribavirin improves outcome of murine viral fulminant hepatitis via enhanced anti-viral activity

Side effects of interferon-ribavirin combination therapy limit the sustained viral response achievable in hepatitis C virus (HCV) patients. Coupling ribavirin to macromolecular carriers that target the drug to the liver would reduce systemic complications. The aim of this study was to evaluate the e...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2006-03, Vol.43 (3), p.581-591
Hauptverfasser:	LEVY, Gary A, ADAMSON, Gord, LEVY, Adam, KOSCIK, Cheryl, HE, William, GORCZYNSKI, Reginald, BROOKES, Steve, WOODS, Caroline, MCGILVRAY, Ian D, BELL, David, PHILLIPS, M. James, SCROCCHI, Louise A, FUNG, Laisum, BIESSELS, Pieter, NG, Nancy F, GHANEKAR, Anand, ROWE, Andrea, XUEZHONG MA, Max
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Antiviral Agents - administration & dosage Biological and medical sciences Coronavirus Infections - complications Coronavirus Infections - drug therapy Drug Delivery Systems Female Gastroenterology. Liver. Pancreas. Abdomen Hepatitis, Viral, Animal - complications Hepatitis, Viral, Animal - drug therapy Hepatocytes - drug effects Hepatocytes - virology Human viral diseases Infectious diseases Liver Failure, Acute - virology Liver. Biliary tract. Portal circulation. Exocrine pancreas Macrophages - drug effects Macrophages - virology Medical sciences Mice Mice, Inbred BALB C Murine hepatitis virus Other diseases. Semiology Outcome Assessment, Health Care Pharmacology. Drug treatments Ribavirin - administration & dosage Viral diseases Viral Hepatitis Virus Replication
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