Modified nucleotides may have enhanced early RNA catalysis

The modern version of the RNA World Hypothesis begins with activated ribonucleotides condensing (nonenzymatically) to make RNA molecules, some of which possess (perhaps slight) catalytic activity. We propose that noncanonical ribonucleotides, which would have been inevitable under prebiotic conditio...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2020-04, Vol.117 (15), p.8236-8242
Hauptverfasser:	Wolk, Steven K., Mayfield, Wesley S., Gelinas, Amy D., Astling, David, Guillot, Jessica, Brody, Edward N., Janjic, Nebojsa, Gold, Larry
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Sciences Catalysis Catalytic activity Cofactors Nucleotides PERSPECTIVE Ribonucleic acid Ribonucleotides RNA
Online-Zugang:	Volltext
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