Synthetic molecular evolution of host cell-compatible, antimicrobial peptides effective against drug-resistant, biofilm-forming bacteria

Novel classes of antibiotics and new strategies to prevent and treat infections are urgently needed because the rapid rise in drugresistant bacterial infections in recent decades has been accompanied by a parallel decline in development of new antibiotics. Membrane permeabilizing antimicrobial pepti...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2020-04, Vol.117 (15), p.8437-8448
Hauptverfasser:	Starr, Charles G., Ghimire, Jenisha, Guha, Shantanu, Hoffmann, Joseph P., Wang, Yihui, Sun, Leisheng, Landreneau, Brooke N., Kolansky, Zachary D., Kilanowski-Doroh, Isabella M., Sammarco, Mimi C., Morici, Lisa A., Wimley, William C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics Antiinfectives and antibacterials Antimicrobial peptides Bacteria Bacterial diseases Biocompatibility Biofilms Biological Sciences Clinical trials Cytotoxicity Drug resistance Evolution Infections Molecular evolution Peptides Proteins Proteolysis Solubility Toxicity Wounds
Online-Zugang:	Volltext
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