Oxygen therapy in premature low birth weight infants is associated with capillary loss and increases in blood pressure: a pilot study
Low birth weight (LBW) and premature birth are known risk factors for future cardiovascular disease and in particular essential hypertension (EH). Capillary rarefaction (CR) is an established hallmark of EH and is known to occur in individuals with a history of LBW. We previously reported that LBW i...
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| Veröffentlicht in: | Journal of human hypertension 2020-04, Vol.34 (4), p.278-285 |
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| creator | Raghuraman, Rajendra P. Duffy, Donovan Carroll, Veronica A. Manyonda, Isaac Antonios, Tarek F. |
| description | Low birth weight (LBW) and premature birth are known risk factors for future cardiovascular disease and in particular essential hypertension (EH). Capillary rarefaction (CR) is an established hallmark of EH and is known to occur in individuals with a history of LBW. We previously reported that LBW infants do not have CR at birth but rather increased capillary density (CD). We hypothesized that LBW infants undergo a process of accelerated CR in early life, triggered in part by oxygen therapy. We studied 26 LBW infants, of whom 10 infants received oxygen therapy, and compared them to 14 normal birth weight (NBW) infants. We measured CD at 1, 5 and 10 days after birth and again after 40 weeks adjusted gestational age equivalent to birth at full term. We confirmed that LBW infants had higher CD at birth compared to NBW infants and found that significant structural CR occurred at term age in LBW infants who had received oxygen therapy (mean difference −22 capillaries/field,
p
= 0.007) and in those who did not receive oxygen therapy (mean difference −29 capillaries/field,
p
|
| doi_str_mv | 10.1038/s41371-019-0211-1 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7165125</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A621196614</galeid><sourcerecordid>A621196614</sourcerecordid><originalsourceid>FETCH-LOGICAL-c596t-742bbdf1d5287f1f70e3b1fa113353da77bc6d6f1dff24ea51f1c533df5b41b63</originalsourceid><addsrcrecordid>eNp9ks1u1DAUhSMEokPhAdggS0iITYqvHccTFkhVVX6kSt3A2nISe-IqYw-202EegPfujaYMHQQoi0g53znx9blF8RLoGVC-fJcq4BJKCk1JGUAJj4oFVLIuhWDycbGgjaBlwyp6UjxL6YbSWVw-LU44UMlBiEXx8_rHbmU8yYOJerMjzpNNNGudp2jIGLakdTEPZGvcasioWu1zIi4RnVLonM6mJ1uHRKc3bhx13KEroex7pLtodDJpTm3HEPo5OyWMfk80QT5kkvLU754XT6wek3lx_z4tvn28_Hrxuby6_vTl4vyq7ERT51JWrG17C71gS2nBSmp4C1YDcC54r6Vsu7qvEbCWVUYLsNAJznsr2gramp8WH_a5m6ldm74zPkc9qk10azy5CtqpY8W7Qa3CrZJQC2ACA97eB8TwfTIpq7VLncHBvQlTUoxxaIA2ckZf_4HehCl6HE8xrEFid6z5L8UbYLSWWNWBWunRKGwh4Om6-dfqvMbmm7qGCqmzv1D49GbtuuCNdfj9yPDmgWEwesxDCuOUXfDpGIQ92EUsNxp7uDKgal5FtV9Fhauo5lVUgJ5XD-_64Pi1ewiwPZBQ8isTf4_-79Q7o6zpZg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2391206707</pqid></control><display><type>article</type><title>Oxygen therapy in premature low birth weight infants is associated with capillary loss and increases in blood pressure: a pilot study</title><source>Springer Nature - Complete Springer Journals</source><creator>Raghuraman, Rajendra P. ; Duffy, Donovan ; Carroll, Veronica A. ; Manyonda, Isaac ; Antonios, Tarek F.</creator><creatorcontrib>Raghuraman, Rajendra P. ; Duffy, Donovan ; Carroll, Veronica A. ; Manyonda, Isaac ; Antonios, Tarek F.</creatorcontrib><description>Low birth weight (LBW) and premature birth are known risk factors for future cardiovascular disease and in particular essential hypertension (EH). Capillary rarefaction (CR) is an established hallmark of EH and is known to occur in individuals with a history of LBW. We previously reported that LBW infants do not have CR at birth but rather increased capillary density (CD). We hypothesized that LBW infants undergo a process of accelerated CR in early life, triggered in part by oxygen therapy. We studied 26 LBW infants, of whom 10 infants received oxygen therapy, and compared them to 14 normal birth weight (NBW) infants. We measured CD at 1, 5 and 10 days after birth and again after 40 weeks adjusted gestational age equivalent to birth at full term. We confirmed that LBW infants had higher CD at birth compared to NBW infants and found that significant structural CR occurred at term age in LBW infants who had received oxygen therapy (mean difference −22 capillaries/field,
p
= 0.007) and in those who did not receive oxygen therapy (mean difference −29 capillaries/field,
p
< 0.001) compared to baseline at birth. Both LBW groups showed a significant rise in BP at 40 weeks adjusted term age and the rise in systolic (mean difference 24 mm Hg,
p
< 0.0001) and diastolic BP (mean difference 14 mm Hg,
p
< 0.001) was more pronounced in the oxygen treated group compared to the nonoxygen group (mean difference 14 mm Hg,
p
= 0.043 and mean difference = 9 mm Hg
p
= 0.056 respectively). In conclusion, oxygen therapy in premature LBW infants may induce significant increases in their BP in early life.</description><identifier>ISSN: 0950-9240</identifier><identifier>EISSN: 1476-5527</identifier><identifier>DOI: 10.1038/s41371-019-0211-1</identifier><identifier>PMID: 31073155</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>59 ; 631/443/1338 ; 631/443/592 ; Birth weight ; Birth weight, Low ; Blood pressure ; Capillaries ; Cardiovascular diseases ; Care and treatment ; Epidemiology ; Gestational age ; Health Administration ; Health aspects ; Infants ; Low-birth-weight ; Medicine ; Medicine & Public Health ; Methods ; Oxygen ; Oxygen therapy ; Premature birth ; Public Health ; Respiratory therapy ; Risk factors</subject><ispartof>Journal of human hypertension, 2020-04, Vol.34 (4), p.278-285</ispartof><rights>Springer Nature Limited 2019</rights><rights>COPYRIGHT 2020 Nature Publishing Group</rights><rights>Springer Nature Limited 2019.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c596t-742bbdf1d5287f1f70e3b1fa113353da77bc6d6f1dff24ea51f1c533df5b41b63</citedby><cites>FETCH-LOGICAL-c596t-742bbdf1d5287f1f70e3b1fa113353da77bc6d6f1dff24ea51f1c533df5b41b63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41371-019-0211-1$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41371-019-0211-1$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,778,782,883,27911,27912,41475,42544,51306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31073155$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Raghuraman, Rajendra P.</creatorcontrib><creatorcontrib>Duffy, Donovan</creatorcontrib><creatorcontrib>Carroll, Veronica A.</creatorcontrib><creatorcontrib>Manyonda, Isaac</creatorcontrib><creatorcontrib>Antonios, Tarek F.</creatorcontrib><title>Oxygen therapy in premature low birth weight infants is associated with capillary loss and increases in blood pressure: a pilot study</title><title>Journal of human hypertension</title><addtitle>J Hum Hypertens</addtitle><addtitle>J Hum Hypertens</addtitle><description>Low birth weight (LBW) and premature birth are known risk factors for future cardiovascular disease and in particular essential hypertension (EH). Capillary rarefaction (CR) is an established hallmark of EH and is known to occur in individuals with a history of LBW. We previously reported that LBW infants do not have CR at birth but rather increased capillary density (CD). We hypothesized that LBW infants undergo a process of accelerated CR in early life, triggered in part by oxygen therapy. We studied 26 LBW infants, of whom 10 infants received oxygen therapy, and compared them to 14 normal birth weight (NBW) infants. We measured CD at 1, 5 and 10 days after birth and again after 40 weeks adjusted gestational age equivalent to birth at full term. We confirmed that LBW infants had higher CD at birth compared to NBW infants and found that significant structural CR occurred at term age in LBW infants who had received oxygen therapy (mean difference −22 capillaries/field,
p
= 0.007) and in those who did not receive oxygen therapy (mean difference −29 capillaries/field,
p
< 0.001) compared to baseline at birth. Both LBW groups showed a significant rise in BP at 40 weeks adjusted term age and the rise in systolic (mean difference 24 mm Hg,
p
< 0.0001) and diastolic BP (mean difference 14 mm Hg,
p
< 0.001) was more pronounced in the oxygen treated group compared to the nonoxygen group (mean difference 14 mm Hg,
p
= 0.043 and mean difference = 9 mm Hg
p
= 0.056 respectively). In conclusion, oxygen therapy in premature LBW infants may induce significant increases in their BP in early life.</description><subject>59</subject><subject>631/443/1338</subject><subject>631/443/592</subject><subject>Birth weight</subject><subject>Birth weight, Low</subject><subject>Blood pressure</subject><subject>Capillaries</subject><subject>Cardiovascular diseases</subject><subject>Care and treatment</subject><subject>Epidemiology</subject><subject>Gestational age</subject><subject>Health Administration</subject><subject>Health aspects</subject><subject>Infants</subject><subject>Low-birth-weight</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Methods</subject><subject>Oxygen</subject><subject>Oxygen therapy</subject><subject>Premature birth</subject><subject>Public Health</subject><subject>Respiratory therapy</subject><subject>Risk factors</subject><issn>0950-9240</issn><issn>1476-5527</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9ks1u1DAUhSMEokPhAdggS0iITYqvHccTFkhVVX6kSt3A2nISe-IqYw-202EegPfujaYMHQQoi0g53znx9blF8RLoGVC-fJcq4BJKCk1JGUAJj4oFVLIuhWDycbGgjaBlwyp6UjxL6YbSWVw-LU44UMlBiEXx8_rHbmU8yYOJerMjzpNNNGudp2jIGLakdTEPZGvcasioWu1zIi4RnVLonM6mJ1uHRKc3bhx13KEroex7pLtodDJpTm3HEPo5OyWMfk80QT5kkvLU754XT6wek3lx_z4tvn28_Hrxuby6_vTl4vyq7ERT51JWrG17C71gS2nBSmp4C1YDcC54r6Vsu7qvEbCWVUYLsNAJznsr2gramp8WH_a5m6ldm74zPkc9qk10azy5CtqpY8W7Qa3CrZJQC2ACA97eB8TwfTIpq7VLncHBvQlTUoxxaIA2ckZf_4HehCl6HE8xrEFid6z5L8UbYLSWWNWBWunRKGwh4Om6-dfqvMbmm7qGCqmzv1D49GbtuuCNdfj9yPDmgWEwesxDCuOUXfDpGIQ92EUsNxp7uDKgal5FtV9Fhauo5lVUgJ5XD-_64Pi1ewiwPZBQ8isTf4_-79Q7o6zpZg</recordid><startdate>20200401</startdate><enddate>20200401</enddate><creator>Raghuraman, Rajendra P.</creator><creator>Duffy, Donovan</creator><creator>Carroll, Veronica A.</creator><creator>Manyonda, Isaac</creator><creator>Antonios, Tarek F.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200401</creationdate><title>Oxygen therapy in premature low birth weight infants is associated with capillary loss and increases in blood pressure: a pilot study</title><author>Raghuraman, Rajendra P. ; Duffy, Donovan ; Carroll, Veronica A. ; Manyonda, Isaac ; Antonios, Tarek F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c596t-742bbdf1d5287f1f70e3b1fa113353da77bc6d6f1dff24ea51f1c533df5b41b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>59</topic><topic>631/443/1338</topic><topic>631/443/592</topic><topic>Birth weight</topic><topic>Birth weight, Low</topic><topic>Blood pressure</topic><topic>Capillaries</topic><topic>Cardiovascular diseases</topic><topic>Care and treatment</topic><topic>Epidemiology</topic><topic>Gestational age</topic><topic>Health Administration</topic><topic>Health aspects</topic><topic>Infants</topic><topic>Low-birth-weight</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Methods</topic><topic>Oxygen</topic><topic>Oxygen therapy</topic><topic>Premature birth</topic><topic>Public Health</topic><topic>Respiratory therapy</topic><topic>Risk factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Raghuraman, Rajendra P.</creatorcontrib><creatorcontrib>Duffy, Donovan</creatorcontrib><creatorcontrib>Carroll, Veronica A.</creatorcontrib><creatorcontrib>Manyonda, Isaac</creatorcontrib><creatorcontrib>Antonios, Tarek F.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of human hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Raghuraman, Rajendra P.</au><au>Duffy, Donovan</au><au>Carroll, Veronica A.</au><au>Manyonda, Isaac</au><au>Antonios, Tarek F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oxygen therapy in premature low birth weight infants is associated with capillary loss and increases in blood pressure: a pilot study</atitle><jtitle>Journal of human hypertension</jtitle><stitle>J Hum Hypertens</stitle><addtitle>J Hum Hypertens</addtitle><date>2020-04-01</date><risdate>2020</risdate><volume>34</volume><issue>4</issue><spage>278</spage><epage>285</epage><pages>278-285</pages><issn>0950-9240</issn><eissn>1476-5527</eissn><abstract>Low birth weight (LBW) and premature birth are known risk factors for future cardiovascular disease and in particular essential hypertension (EH). Capillary rarefaction (CR) is an established hallmark of EH and is known to occur in individuals with a history of LBW. We previously reported that LBW infants do not have CR at birth but rather increased capillary density (CD). We hypothesized that LBW infants undergo a process of accelerated CR in early life, triggered in part by oxygen therapy. We studied 26 LBW infants, of whom 10 infants received oxygen therapy, and compared them to 14 normal birth weight (NBW) infants. We measured CD at 1, 5 and 10 days after birth and again after 40 weeks adjusted gestational age equivalent to birth at full term. We confirmed that LBW infants had higher CD at birth compared to NBW infants and found that significant structural CR occurred at term age in LBW infants who had received oxygen therapy (mean difference −22 capillaries/field,
p
= 0.007) and in those who did not receive oxygen therapy (mean difference −29 capillaries/field,
p
< 0.001) compared to baseline at birth. Both LBW groups showed a significant rise in BP at 40 weeks adjusted term age and the rise in systolic (mean difference 24 mm Hg,
p
< 0.0001) and diastolic BP (mean difference 14 mm Hg,
p
< 0.001) was more pronounced in the oxygen treated group compared to the nonoxygen group (mean difference 14 mm Hg,
p
= 0.043 and mean difference = 9 mm Hg
p
= 0.056 respectively). In conclusion, oxygen therapy in premature LBW infants may induce significant increases in their BP in early life.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>31073155</pmid><doi>10.1038/s41371-019-0211-1</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | Springer Nature - Complete Springer Journals |
| subjects | 59 631/443/1338 631/443/592 Birth weight Birth weight, Low Blood pressure Capillaries Cardiovascular diseases Care and treatment Epidemiology Gestational age Health Administration Health aspects Infants Low-birth-weight Medicine Medicine & Public Health Methods Oxygen Oxygen therapy Premature birth Public Health Respiratory therapy Risk factors |
| title | Oxygen therapy in premature low birth weight infants is associated with capillary loss and increases in blood pressure: a pilot study |
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