Androgen receptor with short polyglutamine tract preferably enhances Wnt/β-catenin-mediated prostatic tumorigenesis

Polyglutamine (polyQ) tract polymorphism within the human androgen receptor (AR) shows population heterogeneity. African American men possess short polyQ tracts significantly more frequently than Caucasian American men. The length of polyQ tracts is inversely correlated with the risk of prostate can...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Oncogene 2020-04, Vol.39 (16), p.3276-3291
Hauptverfasser:	He, Yongfeng, Mi, Jiaqi, Olson, Adam, Aldahl, Joseph, Hooker, Erika, Yu, Eun-Jeong, Le, Vien, Lee, Dong-Hoon, Kim, Won Kyung, Robins, Diane M., Geradts, Joseph, Sun, Zijie
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/589/466 631/67/70 African Americans African Americans - genetics Androgen receptors Androgens Animal models Animals Apoptosis beta Catenin - genetics c-Myc protein Carcinogenesis - genetics Cell Biology Cell Proliferation - genetics Chromatin Disease Models, Animal Gene Expression Regulation, Neoplastic - genetics Human Genetics Humans Immunoprecipitation Internal Medicine Male Medicine Medicine & Public Health Mice Myc protein Oncology Peptides - genetics Phenotypes Polyglutamine Prostate - metabolism Prostate - pathology Prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology Proto-Oncogene Proteins c-myc - genetics Receptors, Androgen - genetics Ribonucleic acid RNA Sequence analysis Sequence Analysis, RNA Transcription Trinucleotide repeat diseases Tumor cells Tumorigenesis Wnt protein Wnt Signaling Pathway - genetics β-Catenin
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!