What is the effect of the early follicular phase FSH/LH ratio on the number of mature oocytes and embryo development?
Basal level of follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), and antral follicle count are used as predictors of ovarian reserve before starting ovulation induction. We aimed to investigate the predictor potential of early follicular phase FSH/LH ratio on controlled o...
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| Veröffentlicht in: | TURKISH JOURNAL OF MEDICAL SCIENCES 2020-04, Vol.50 (2), p.420-425 |
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| creator | Arat, Özgür Deveci, Derya Özkan, Zehra Sema Tuncer Can, Sevim |
| description | Basal level of follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), and antral follicle count are used as predictors of ovarian reserve before starting ovulation induction. We aimed to investigate the predictor potential of early follicular phase FSH/LH ratio on controlled ovarian hyperstimulation-intracytoplasmic sperm injection (COH-ICSI) cycle outcomes.
This retrospective cohort study was conducted with 648 COH-ICSI cycles performed between 2012 and 2014. Cycles were classified according to their basal FSH/LH ratio, group 1(G1) = FSH/LH ratio < 2, N = 473 and group 2(G2) = FSH/LH ratio ≥ 2, N = 175. Demographic characteristics and stimulation parameters were evaluated. Retrieved total oocyte count (TOC), mature oocyte count (MOC), transferred embryo number, and pregnancy results were obtained and transferred to computer by SPSS 21.0 programme.
TOC and MOC of G1 were significantly higher than those of G2. The total gonadotrophin doses of G2 were significantly higher than G1. There was no significant difference between groups for transferred embryo number. Pregnancy and live birth rates were similar in both groups.
In our population, increased FSH/LH ratio did not affect the rates of pregnancy and live birth negatively. |
| doi_str_mv | 10.3906/sag-1910-234 |
| format | Article |
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This retrospective cohort study was conducted with 648 COH-ICSI cycles performed between 2012 and 2014. Cycles were classified according to their basal FSH/LH ratio, group 1(G1) = FSH/LH ratio < 2, N = 473 and group 2(G2) = FSH/LH ratio ≥ 2, N = 175. Demographic characteristics and stimulation parameters were evaluated. Retrieved total oocyte count (TOC), mature oocyte count (MOC), transferred embryo number, and pregnancy results were obtained and transferred to computer by SPSS 21.0 programme.
TOC and MOC of G1 were significantly higher than those of G2. The total gonadotrophin doses of G2 were significantly higher than G1. There was no significant difference between groups for transferred embryo number. Pregnancy and live birth rates were similar in both groups.
In our population, increased FSH/LH ratio did not affect the rates of pregnancy and live birth negatively.</description><identifier>ISSN: 1303-6165</identifier><identifier>ISSN: 1300-0144</identifier><identifier>EISSN: 1303-6165</identifier><identifier>DOI: 10.3906/sag-1910-234</identifier><identifier>PMID: 32093445</identifier><language>eng</language><publisher>Turkey: The Scientific and Technological Research Council of Turkey</publisher><subject>Adult ; Embryonic Development - physiology ; Female ; Follicle Stimulating Hormone - blood ; Follicular Phase - physiology ; Humans ; Luteinizing Hormone - blood ; Oocytes - physiology ; Pregnancy ; Pregnancy Outcome - epidemiology ; Retrospective Studies</subject><ispartof>TURKISH JOURNAL OF MEDICAL SCIENCES, 2020-04, Vol.50 (2), p.420-425</ispartof><rights>This work is licensed under a Creative Commons Attribution 4.0 International License.</rights><rights>Copyright © 2019 The Author(s) 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-8db49c999f28e51dd466ab26742c1349070333b3cc6fecd408ad5c2e919737b53</citedby><cites>FETCH-LOGICAL-c384t-8db49c999f28e51dd466ab26742c1349070333b3cc6fecd408ad5c2e919737b53</cites><orcidid>0000-0003-0445-1653 ; 0000-0001-9185-3663 ; 0000-0003-3119-1148 ; 0000-0002-9867-0867</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164748/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164748/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32093445$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arat, Özgür</creatorcontrib><creatorcontrib>Deveci, Derya</creatorcontrib><creatorcontrib>Özkan, Zehra Sema</creatorcontrib><creatorcontrib>Tuncer Can, Sevim</creatorcontrib><title>What is the effect of the early follicular phase FSH/LH ratio on the number of mature oocytes and embryo development?</title><title>TURKISH JOURNAL OF MEDICAL SCIENCES</title><addtitle>Turk J Med Sci</addtitle><description>Basal level of follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), and antral follicle count are used as predictors of ovarian reserve before starting ovulation induction. We aimed to investigate the predictor potential of early follicular phase FSH/LH ratio on controlled ovarian hyperstimulation-intracytoplasmic sperm injection (COH-ICSI) cycle outcomes.
This retrospective cohort study was conducted with 648 COH-ICSI cycles performed between 2012 and 2014. Cycles were classified according to their basal FSH/LH ratio, group 1(G1) = FSH/LH ratio < 2, N = 473 and group 2(G2) = FSH/LH ratio ≥ 2, N = 175. Demographic characteristics and stimulation parameters were evaluated. Retrieved total oocyte count (TOC), mature oocyte count (MOC), transferred embryo number, and pregnancy results were obtained and transferred to computer by SPSS 21.0 programme.
TOC and MOC of G1 were significantly higher than those of G2. The total gonadotrophin doses of G2 were significantly higher than G1. There was no significant difference between groups for transferred embryo number. Pregnancy and live birth rates were similar in both groups.
In our population, increased FSH/LH ratio did not affect the rates of pregnancy and live birth negatively.</description><subject>Adult</subject><subject>Embryonic Development - physiology</subject><subject>Female</subject><subject>Follicle Stimulating Hormone - blood</subject><subject>Follicular Phase - physiology</subject><subject>Humans</subject><subject>Luteinizing Hormone - blood</subject><subject>Oocytes - physiology</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome - epidemiology</subject><subject>Retrospective Studies</subject><issn>1303-6165</issn><issn>1300-0144</issn><issn>1303-6165</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkFFLwzAUhYMobk7ffJb8AOuSJk2bF0WGc8LABxUfQ5qka6VtSpIO-u_tnI75dO_lnnvO5QPgGqM7whGbe7mJMMcoigk9AVNMEIkYZsnpUT8BF95_ITRKEn4OJiRGnFCaTEH_WcoAKw9DaaApCqMCtMV-kq4eYGHrulJ9LR3sSukNXL6t5usVdDJUFtr2R9r2TW7c7rCRoXcGWquGYDyUrYamyd1goTZbU9uuMW14uARnhay9ufqtM_CxfHpfrKL16_PL4nEdKZLREGU6p1xxzos4MwnWmjIm85ilNFaYUI5SRAjJiVJsfFxTlEmdqNhwzFOS5gmZgfu9b9fnjdFqzHayFp2rGukGYWUl_m_aqhQbuxUpZjSl2WhwuzdQznrvTHG4xUjs8IsRv9jhFyPbUX5znHcQ__Em3-a-gp0</recordid><startdate>20200409</startdate><enddate>20200409</enddate><creator>Arat, Özgür</creator><creator>Deveci, Derya</creator><creator>Özkan, Zehra Sema</creator><creator>Tuncer Can, Sevim</creator><general>The Scientific and Technological Research Council of Turkey</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0445-1653</orcidid><orcidid>https://orcid.org/0000-0001-9185-3663</orcidid><orcidid>https://orcid.org/0000-0003-3119-1148</orcidid><orcidid>https://orcid.org/0000-0002-9867-0867</orcidid></search><sort><creationdate>20200409</creationdate><title>What is the effect of the early follicular phase FSH/LH ratio on the number of mature oocytes and embryo development?</title><author>Arat, Özgür ; Deveci, Derya ; Özkan, Zehra Sema ; Tuncer Can, Sevim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-8db49c999f28e51dd466ab26742c1349070333b3cc6fecd408ad5c2e919737b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Embryonic Development - physiology</topic><topic>Female</topic><topic>Follicle Stimulating Hormone - blood</topic><topic>Follicular Phase - physiology</topic><topic>Humans</topic><topic>Luteinizing Hormone - blood</topic><topic>Oocytes - physiology</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome - epidemiology</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Arat, Özgür</creatorcontrib><creatorcontrib>Deveci, Derya</creatorcontrib><creatorcontrib>Özkan, Zehra Sema</creatorcontrib><creatorcontrib>Tuncer Can, Sevim</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>TURKISH JOURNAL OF MEDICAL SCIENCES</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arat, Özgür</au><au>Deveci, Derya</au><au>Özkan, Zehra Sema</au><au>Tuncer Can, Sevim</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>What is the effect of the early follicular phase FSH/LH ratio on the number of mature oocytes and embryo development?</atitle><jtitle>TURKISH JOURNAL OF MEDICAL SCIENCES</jtitle><addtitle>Turk J Med Sci</addtitle><date>2020-04-09</date><risdate>2020</risdate><volume>50</volume><issue>2</issue><spage>420</spage><epage>425</epage><pages>420-425</pages><issn>1303-6165</issn><issn>1300-0144</issn><eissn>1303-6165</eissn><abstract>Basal level of follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), and antral follicle count are used as predictors of ovarian reserve before starting ovulation induction. We aimed to investigate the predictor potential of early follicular phase FSH/LH ratio on controlled ovarian hyperstimulation-intracytoplasmic sperm injection (COH-ICSI) cycle outcomes.
This retrospective cohort study was conducted with 648 COH-ICSI cycles performed between 2012 and 2014. Cycles were classified according to their basal FSH/LH ratio, group 1(G1) = FSH/LH ratio < 2, N = 473 and group 2(G2) = FSH/LH ratio ≥ 2, N = 175. Demographic characteristics and stimulation parameters were evaluated. Retrieved total oocyte count (TOC), mature oocyte count (MOC), transferred embryo number, and pregnancy results were obtained and transferred to computer by SPSS 21.0 programme.
TOC and MOC of G1 were significantly higher than those of G2. The total gonadotrophin doses of G2 were significantly higher than G1. There was no significant difference between groups for transferred embryo number. Pregnancy and live birth rates were similar in both groups.
In our population, increased FSH/LH ratio did not affect the rates of pregnancy and live birth negatively.</abstract><cop>Turkey</cop><pub>The Scientific and Technological Research Council of Turkey</pub><pmid>32093445</pmid><doi>10.3906/sag-1910-234</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-0445-1653</orcidid><orcidid>https://orcid.org/0000-0001-9185-3663</orcidid><orcidid>https://orcid.org/0000-0003-3119-1148</orcidid><orcidid>https://orcid.org/0000-0002-9867-0867</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Embryonic Development - physiology Female Follicle Stimulating Hormone - blood Follicular Phase - physiology Humans Luteinizing Hormone - blood Oocytes - physiology Pregnancy Pregnancy Outcome - epidemiology Retrospective Studies |
| title | What is the effect of the early follicular phase FSH/LH ratio on the number of mature oocytes and embryo development? |
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