Aminopeptidase‐N/CD13 is a potential proapoptotic target in human myeloid tumor cells

ABSTRACT The transmembrane metalloprotease aminopeptidase‐N (APN)/CD13 is overexpressed in various solid and hematological malignancies in humans, including acute myeloid leukemia (AML) and is thought to influence tumor progression. Here, we investigated the contribution of APN/CD13 to the regulatio...

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Veröffentlicht in:	The FASEB journal 2011-08, Vol.25 (8), p.2831-2842
Hauptverfasser:	Piedfer, Marion, Dauzonne, Daniel, Tang, Ruoping, N'Guyen, Juliette, Billard, Christian, Bauvois, Brigitte
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over AML Antibodies, Monoclonal - pharmacology antibody APN Apoptosis - drug effects Apoptosis - physiology bcl-2-Associated X Protein - metabolism Bcl‐2 family Caspases - metabolism CD13 Antigens - antagonists & inhibitors CD13 Antigens - immunology CD13 Antigens - physiology Cell Proliferation - drug effects Cell Survival - drug effects Enzyme Inhibitors - pharmacology Female Humans In Vitro Techniques inhibitor Leukemia, Myeloid, Acute - enzymology Leukemia, Myeloid, Acute - pathology Leukemia, Myeloid, Acute - therapy Male MAP Kinase Kinase 1 - antagonists & inhibitors Membrane Potential, Mitochondrial Middle Aged Myeloid Cell Leukemia Sequence 1 Protein Phosphoinositide-3 Kinase Inhibitors Poly (ADP-Ribose) Polymerase-1 Poly(ADP-ribose) Polymerases - metabolism Protease Inhibitors - pharmacology Proto-Oncogene Proteins c-akt - antagonists & inhibitors Proto-Oncogene Proteins c-bcl-2 - metabolism Research Communication Research Communications U937 Cells Young Adult
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