Morphological alterations of the reticular thalamic nucleus in Engrailed‐2 knockout mice

The reticular thalamic nucleus (Rt) is a sheet of neurons that surrounds the dorsal thalamus laterally, along its dorso‐ventral and rostro‐caudal axes. It consists of inhibitory neurons releasing gamma‐aminobutyric acid (GABA). This nucleus participates in the circuitry between the thalamus and the...

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Veröffentlicht in:Journal of anatomy 2020-05, Vol.236 (5), p.883-890
Hauptverfasser: Pirone, Andrea, Viaggi, Cristina, Cantile, Carlo, Giannessi, Elisabetta, Pardini, Carla, Vaglini, Francesca, Miragliotta, Vincenzo
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container_issue 5
container_start_page 883
container_title Journal of anatomy
container_volume 236
creator Pirone, Andrea
Viaggi, Cristina
Cantile, Carlo
Giannessi, Elisabetta
Pardini, Carla
Vaglini, Francesca
Miragliotta, Vincenzo
description The reticular thalamic nucleus (Rt) is a sheet of neurons that surrounds the dorsal thalamus laterally, along its dorso‐ventral and rostro‐caudal axes. It consists of inhibitory neurons releasing gamma‐aminobutyric acid (GABA). This nucleus participates in the circuitry between the thalamus and the cerebral cortex, and its impairment is associated with neuro‐psychiatric disorders. In this study, we investigated the Rt anatomy of Engrailed‐2 knockout mice (En2−/−), a mouse model of autism spectrum disorder (ASD), using parvalbumin as an immunohistochemical marker. We compared 4‐ and 6‐week‐old wild type (WT) and En2−/− mice using various morphometric parameters: cell area, shape factor, circularity and cell density. Significant differences were present in 6‐week‐old male mice with different genetic background (WT vs. En2−/−): the Rt neurons of En2−/− mice showed a bigger cell area, shape factor and circularity when compared with WT. Age (4 weeks vs. 6 weeks) influenced the shape factor of WT females, the circularity and cell density of En2−/− males, and the shape factor and circularity of En2−/− females. Gender affected cell density in 4‐week‐old WT mice, shape factor and cellularity of 6‐week‐old WT mice, and cell area, shape factor and cell density of En2−/− at 6 weeks. Intrasubject (left–right) asymmetry of Rt was never observed. These results show for the first time that sex‐ and age‐related changes occur in the Rt GABAergic neurons of the En2−/− ASD mouse model. The reticular thalamic nucleus (Rt) is a sheet of neurons that surrounds the dorsal thalamus laterally, along its dorso‐ventral and rostro‐caudal axes. This nucleus consists of inhibitory neurons releasing gamma‐aminobutyric acid (GABA). We investigated the Rt anatomy of Engrailed‐2 knockout mice (En2−/−), a mouse model of autism spectrum disorder (ASD) using parvalbumin as an immunohistochemical marker. The present study showed for the first time that changes occur in the Rt GABAergic neurons of En2−/− mice of both sex at 4 and 6 weeks of age. This may lead to abnormal functioning of the Rt that seems to have a critical role in the regulation of attention in models of autism and neurodevelopmental disorders.
doi_str_mv 10.1111/joa.13150
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It consists of inhibitory neurons releasing gamma‐aminobutyric acid (GABA). This nucleus participates in the circuitry between the thalamus and the cerebral cortex, and its impairment is associated with neuro‐psychiatric disorders. In this study, we investigated the Rt anatomy of Engrailed‐2 knockout mice (En2−/−), a mouse model of autism spectrum disorder (ASD), using parvalbumin as an immunohistochemical marker. We compared 4‐ and 6‐week‐old wild type (WT) and En2−/− mice using various morphometric parameters: cell area, shape factor, circularity and cell density. Significant differences were present in 6‐week‐old male mice with different genetic background (WT vs. En2−/−): the Rt neurons of En2−/− mice showed a bigger cell area, shape factor and circularity when compared with WT. Age (4 weeks vs. 6 weeks) influenced the shape factor of WT females, the circularity and cell density of En2−/− males, and the shape factor and circularity of En2−/− females. Gender affected cell density in 4‐week‐old WT mice, shape factor and cellularity of 6‐week‐old WT mice, and cell area, shape factor and cell density of En2−/− at 6 weeks. Intrasubject (left–right) asymmetry of Rt was never observed. These results show for the first time that sex‐ and age‐related changes occur in the Rt GABAergic neurons of the En2−/− ASD mouse model. The reticular thalamic nucleus (Rt) is a sheet of neurons that surrounds the dorsal thalamus laterally, along its dorso‐ventral and rostro‐caudal axes. This nucleus consists of inhibitory neurons releasing gamma‐aminobutyric acid (GABA). We investigated the Rt anatomy of Engrailed‐2 knockout mice (En2−/−), a mouse model of autism spectrum disorder (ASD) using parvalbumin as an immunohistochemical marker. The present study showed for the first time that changes occur in the Rt GABAergic neurons of En2−/− mice of both sex at 4 and 6 weeks of age. 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It consists of inhibitory neurons releasing gamma‐aminobutyric acid (GABA). This nucleus participates in the circuitry between the thalamus and the cerebral cortex, and its impairment is associated with neuro‐psychiatric disorders. In this study, we investigated the Rt anatomy of Engrailed‐2 knockout mice (En2−/−), a mouse model of autism spectrum disorder (ASD), using parvalbumin as an immunohistochemical marker. We compared 4‐ and 6‐week‐old wild type (WT) and En2−/− mice using various morphometric parameters: cell area, shape factor, circularity and cell density. Significant differences were present in 6‐week‐old male mice with different genetic background (WT vs. En2−/−): the Rt neurons of En2−/− mice showed a bigger cell area, shape factor and circularity when compared with WT. Age (4 weeks vs. 6 weeks) influenced the shape factor of WT females, the circularity and cell density of En2−/− males, and the shape factor and circularity of En2−/− females. Gender affected cell density in 4‐week‐old WT mice, shape factor and cellularity of 6‐week‐old WT mice, and cell area, shape factor and cell density of En2−/− at 6 weeks. Intrasubject (left–right) asymmetry of Rt was never observed. These results show for the first time that sex‐ and age‐related changes occur in the Rt GABAergic neurons of the En2−/− ASD mouse model. The reticular thalamic nucleus (Rt) is a sheet of neurons that surrounds the dorsal thalamus laterally, along its dorso‐ventral and rostro‐caudal axes. This nucleus consists of inhibitory neurons releasing gamma‐aminobutyric acid (GABA). We investigated the Rt anatomy of Engrailed‐2 knockout mice (En2−/−), a mouse model of autism spectrum disorder (ASD) using parvalbumin as an immunohistochemical marker. The present study showed for the first time that changes occur in the Rt GABAergic neurons of En2−/− mice of both sex at 4 and 6 weeks of age. 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It consists of inhibitory neurons releasing gamma‐aminobutyric acid (GABA). This nucleus participates in the circuitry between the thalamus and the cerebral cortex, and its impairment is associated with neuro‐psychiatric disorders. In this study, we investigated the Rt anatomy of Engrailed‐2 knockout mice (En2−/−), a mouse model of autism spectrum disorder (ASD), using parvalbumin as an immunohistochemical marker. We compared 4‐ and 6‐week‐old wild type (WT) and En2−/− mice using various morphometric parameters: cell area, shape factor, circularity and cell density. Significant differences were present in 6‐week‐old male mice with different genetic background (WT vs. En2−/−): the Rt neurons of En2−/− mice showed a bigger cell area, shape factor and circularity when compared with WT. Age (4 weeks vs. 6 weeks) influenced the shape factor of WT females, the circularity and cell density of En2−/− males, and the shape factor and circularity of En2−/− females. Gender affected cell density in 4‐week‐old WT mice, shape factor and cellularity of 6‐week‐old WT mice, and cell area, shape factor and cell density of En2−/− at 6 weeks. Intrasubject (left–right) asymmetry of Rt was never observed. These results show for the first time that sex‐ and age‐related changes occur in the Rt GABAergic neurons of the En2−/− ASD mouse model. The reticular thalamic nucleus (Rt) is a sheet of neurons that surrounds the dorsal thalamus laterally, along its dorso‐ventral and rostro‐caudal axes. This nucleus consists of inhibitory neurons releasing gamma‐aminobutyric acid (GABA). We investigated the Rt anatomy of Engrailed‐2 knockout mice (En2−/−), a mouse model of autism spectrum disorder (ASD) using parvalbumin as an immunohistochemical marker. The present study showed for the first time that changes occur in the Rt GABAergic neurons of En2−/− mice of both sex at 4 and 6 weeks of age. This may lead to abnormal functioning of the Rt that seems to have a critical role in the regulation of attention in models of autism and neurodevelopmental disorders.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31972897</pmid><doi>10.1111/joa.13150</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-7896-5695</orcidid><orcidid>https://orcid.org/0000-0001-6363-392X</orcidid><oa>free_for_read</oa></addata></record>
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subjects Animals
Autism
autism spectrum disorder
Autism Spectrum Disorder - genetics
Autism Spectrum Disorder - metabolism
Cell density
Cerebral cortex
Disease Models, Animal
engrailed
Engrailed-2 protein
Female
gamma‐aminobutyric acid
Gender
Homeodomain Proteins - genetics
Homeodomain Proteins - metabolism
Male
Mental disorders
Mice
Mice, Knockout
mouse
Nerve Tissue Proteins - genetics
Nerve Tissue Proteins - metabolism
Neurons
Neurons - metabolism
Original
Original Paper
Parvalbumin
Parvalbumins - metabolism
reticular thalamic nucleus
Rodents
Sex Factors
Thalamic Nuclei - metabolism
Thalamic reticular nucleus
Thalamus
γ-Aminobutyric acid
title Morphological alterations of the reticular thalamic nucleus in Engrailed‐2 knockout mice
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