Post‐translational regulation of antiviral innate signaling

The innate immune system initiates immune responses by pattern‐recognition receptors (PRR). Virus‐derived nucleic acids are sensed by the retinoic acid‐inducible gene I (RIG‐I)‐like receptor (RLR) family and the toll‐like receptor (TLR) family as well as the DNA sensor cyclic GMP‐AMP (cGAMP) synthas...

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Veröffentlicht in:	European journal of immunology 2017-09, Vol.47 (9), p.1414-1426
Hauptverfasser:	Zhou, Yilong, He, Chenxi, Wang, Lin, Ge, Baoxue
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Adenosine diphosphate ADP-ribosylation Amino acids AMP Animals Antiviral drugs Antiviral immunity Cyclic GMP Deoxyribonucleic acid DNA DNA, Viral - immunology Functional groups Highlights Homeostasis Humans Immune response Immunity, Innate Innate immunity Interferon Interferon regulatory factor 3 Interferon Type I - genetics Interferon Type I - metabolism Interferons Methylation NF-kappa B - metabolism NF-κB protein Nucleic acids Phosphorylation Post-translation Post‐translational modifications Protein Processing, Post-Translational PRR Receptors, Pattern Recognition - metabolism Retinoic acid Review\|Basic Ribosylation RNA, Viral - immunology Signal Transduction SUMO protein Toll-like receptors Toll-Like Receptors - metabolism Translation Ubiquitination Virus Diseases - immunology Viruses
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