Replicating predictive serum correlates of greater translocator protein distribution volume in brain

Greater activation of glia, a key component of neuroinflammation, is an important process to target in neuropsychiatric illnesses. However, the magnitude of gliosis varies across cases so low-cost predictors are needed to stratify subjects for clinical trials. Here, several such blood serum measures...

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Veröffentlicht in:	Neuropsychopharmacology (New York, N.Y.) N.Y.), 2020-05, Vol.45 (6), p.925-931
Hauptverfasser:	Attwells, Sophia, Setiawan, Elaine, Wilson, Alan A, Rusjan, Pablo M, Miler, Laura, Xu, Cynthia, Hutton, Celeste, Husain, Muhammad I, Kish, Stephen, Vasdev, Neil, Houle, Sylvain, Meyer, Jeffrey H
Format:	Artikel
Sprache:	eng
Schlagworte:	Astrocytes Blood levels C-reactive protein Clinical trials Gliosis Inflammation Mental depression Microglia Neuronal-glial interactions Obsessive compulsive disorder Positron emission tomography Prefrontal cortex Prostaglandin E2 Proteins Tumor necrosis factor-α
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