Rapid Dynamics of Signal-Dependent Transcriptional Repression by Capicua

Optogenetic perturbations, live imaging, and time-resolved ChIP-seq assays in Drosophila embryos were used to dissect the ERK-dependent control of the HMG-box repressor Capicua (Cic), which plays critical roles in development and is deregulated in human spinocerebellar ataxia and cancers. We establi...

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Veröffentlicht in:	Developmental cell 2020-03, Vol.52 (6), p.794-801.e4
Hauptverfasser:	Keenan, Shannon E., Blythe, Shelby A., Marmion, Robert A., Djabrayan, Nareg J.-V., Wieschaus, Eric F., Shvartsman, Stanislav Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus Animals Capicua Cell Nucleus - metabolism cellular signaling development Drosophila Drosophila melanogaster Drosophila Proteins - genetics Drosophila Proteins - metabolism ERK Extracellular Signal-Regulated MAP Kinases - metabolism Gene Expression Regulation, Developmental HMGB Proteins - genetics HMGB Proteins - metabolism MAP Kinase Signaling System optogenetics Protein Binding Repressor Proteins - genetics Repressor Proteins - metabolism transcriptional repression
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