Quality of life, cognitive, physical and emotional function at diagnosis predicts head and neck cancer survival: analysis of cases from the Head and Neck 5000 study
Purpose The aim of this paper is to determine whether health-related quality of life (HRQOL) at diagnosis of head and neck cancer (HNC) is associated with overall survival following treatment with curative intent after adjusting for other factors. Methods Data were collected from 5511 participants o...
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| Veröffentlicht in: | European archives of oto-rhino-laryngology 2020-05, Vol.277 (5), p.1515-1523 |
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| creator | Rogers, S. N. Waylen, A. E. Thomas, S. Penfold, C. Pring, M. Waterboer, T. Pawlita, M. Hurley, K. Ness, A. R. |
| description | Purpose
The aim of this paper is to determine whether health-related quality of life (HRQOL) at diagnosis of head and neck cancer (HNC) is associated with overall survival following treatment with curative intent after adjusting for other factors.
Methods
Data were collected from 5511 participants of the Head and Neck 5000 study (HN5000). HRQOL was measured using the EORTC QLQ-C30. Questionnaire and covariate data were available from 2171 participants diagnosed as follows: oral cavity (655), oropharynx HPV+ (723) and HPV− (277), and larynx (516). On average, participants were followed up 3.2 years (SD 1.2) after diagnosis. Data were adjusted for age, gender, co-morbidity, intended treatment, education level, income from benefits, smoking status and alcohol consumption.
Results
There was a clinically meaningful difference between Global HRQOL scores at diagnosis and survival in an unadjusted and adjusted model: [HR = 0.86, CI 0.82–0.89,
p
|
| doi_str_mv | 10.1007/s00405-020-05850-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7160091</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2356606762</sourcerecordid><originalsourceid>FETCH-LOGICAL-c446t-938d60db72f38d2361dfed145df4d8823c958e1c20f2c45ef42d0566c9dab4523</originalsourceid><addsrcrecordid>eNp9Uctu1DAUtRCITgs_wAJ5yYLAjV9JWCChilKkCoQEa8vjx4xLxh5sZ9T8Dx-K02kr2LDyse55XN2D0IsW3rQA3dsMwIA3QKAB3nNobh6hVcsoa1hHxGO0goF2DWNdd4JOc74GAM4G-hSdUAKCdIyu0O9vkxp9mXF0ePTOvsY6boIv_lDhfjtnr9WIVTDY7mLxMdSfm4JeIFYFG682IWaf8T5Z43XJeGuVuVUEq39irYK2CecpHfxBje_qRI3zIqiJWmWbsUtxh8vW4st75ZdFyeu-OJfJzM_QE6fGbJ_fvWfox8XH7-eXzdXXT5_PP1w1mjFRmoH2RoBZd8RVRKhojbOmZdw4ZvqeUD3w3raagCOacesYMcCF0INRa8YJPUPvj777ab2zRttQkhrlPvmdSrOMyst_J8Fv5SYeZNcKgKGtBq_uDFL8Ndlc5M5nbcdRBRunLAmtcSA6sWSRI1WnmHOy7iGmBbnUK4_1ylqvvK1X3lTRy78XfJDc91kJ9EjIdRQ2NsnrOKV68fw_2z-t07QF</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2356606762</pqid></control><display><type>article</type><title>Quality of life, cognitive, physical and emotional function at diagnosis predicts head and neck cancer survival: analysis of cases from the Head and Neck 5000 study</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Rogers, S. N. ; Waylen, A. E. ; Thomas, S. ; Penfold, C. ; Pring, M. ; Waterboer, T. ; Pawlita, M. ; Hurley, K. ; Ness, A. R.</creator><creatorcontrib>Rogers, S. N. ; Waylen, A. E. ; Thomas, S. ; Penfold, C. ; Pring, M. ; Waterboer, T. ; Pawlita, M. ; Hurley, K. ; Ness, A. R.</creatorcontrib><description>Purpose
The aim of this paper is to determine whether health-related quality of life (HRQOL) at diagnosis of head and neck cancer (HNC) is associated with overall survival following treatment with curative intent after adjusting for other factors.
Methods
Data were collected from 5511 participants of the Head and Neck 5000 study (HN5000). HRQOL was measured using the EORTC QLQ-C30. Questionnaire and covariate data were available from 2171 participants diagnosed as follows: oral cavity (655), oropharynx HPV+ (723) and HPV− (277), and larynx (516). On average, participants were followed up 3.2 years (SD 1.2) after diagnosis. Data were adjusted for age, gender, co-morbidity, intended treatment, education level, income from benefits, smoking status and alcohol consumption.
Results
There was a clinically meaningful difference between Global HRQOL scores at diagnosis and survival in an unadjusted and adjusted model: [HR = 0.86, CI 0.82–0.89,
p
< 0.001 (unadjusted) and HR = 0.90, CI 0.86–0.94,
p
< 0.001 (adjusted)]. In analyses stratified by tumour site and HPV status, this association was similarly noted before adjustment and persisted after. There were some tumour sub-site variations: improved survival for people with laryngeal cancer reporting higher levels of physical role or social functioning and people with oral cancer reporting higher levels of role or social functioning.
Conclusion
As survival is the main priority for most people diagnosed with cancer, pre-treatment HRQOL is an additional factor to be included in risk stratification and case-mix adjustments. There is merit in incorporating HRQOL into routine clinical care as this is a useful facet in patient-clinician decision making, prognostication and recovery.</description><identifier>ISSN: 0937-4477</identifier><identifier>EISSN: 1434-4726</identifier><identifier>DOI: 10.1007/s00405-020-05850-x</identifier><identifier>PMID: 32062743</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Carcinoma, Squamous Cell ; Cognition ; Head and Neck ; Head and Neck Neoplasms - diagnosis ; Head and Neck Neoplasms - therapy ; Head and Neck Surgery ; Humans ; Medicine ; Medicine & Public Health ; Neurosurgery ; Otorhinolaryngology ; Prognosis ; Quality of Life</subject><ispartof>European archives of oto-rhino-laryngology, 2020-05, Vol.277 (5), p.1515-1523</ispartof><rights>The Author(s) 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c446t-938d60db72f38d2361dfed145df4d8823c958e1c20f2c45ef42d0566c9dab4523</citedby><cites>FETCH-LOGICAL-c446t-938d60db72f38d2361dfed145df4d8823c958e1c20f2c45ef42d0566c9dab4523</cites><orcidid>0000-0002-5989-6142</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00405-020-05850-x$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00405-020-05850-x$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32062743$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rogers, S. N.</creatorcontrib><creatorcontrib>Waylen, A. E.</creatorcontrib><creatorcontrib>Thomas, S.</creatorcontrib><creatorcontrib>Penfold, C.</creatorcontrib><creatorcontrib>Pring, M.</creatorcontrib><creatorcontrib>Waterboer, T.</creatorcontrib><creatorcontrib>Pawlita, M.</creatorcontrib><creatorcontrib>Hurley, K.</creatorcontrib><creatorcontrib>Ness, A. R.</creatorcontrib><title>Quality of life, cognitive, physical and emotional function at diagnosis predicts head and neck cancer survival: analysis of cases from the Head and Neck 5000 study</title><title>European archives of oto-rhino-laryngology</title><addtitle>Eur Arch Otorhinolaryngol</addtitle><addtitle>Eur Arch Otorhinolaryngol</addtitle><description>Purpose
The aim of this paper is to determine whether health-related quality of life (HRQOL) at diagnosis of head and neck cancer (HNC) is associated with overall survival following treatment with curative intent after adjusting for other factors.
Methods
Data were collected from 5511 participants of the Head and Neck 5000 study (HN5000). HRQOL was measured using the EORTC QLQ-C30. Questionnaire and covariate data were available from 2171 participants diagnosed as follows: oral cavity (655), oropharynx HPV+ (723) and HPV− (277), and larynx (516). On average, participants were followed up 3.2 years (SD 1.2) after diagnosis. Data were adjusted for age, gender, co-morbidity, intended treatment, education level, income from benefits, smoking status and alcohol consumption.
Results
There was a clinically meaningful difference between Global HRQOL scores at diagnosis and survival in an unadjusted and adjusted model: [HR = 0.86, CI 0.82–0.89,
p
< 0.001 (unadjusted) and HR = 0.90, CI 0.86–0.94,
p
< 0.001 (adjusted)]. In analyses stratified by tumour site and HPV status, this association was similarly noted before adjustment and persisted after. There were some tumour sub-site variations: improved survival for people with laryngeal cancer reporting higher levels of physical role or social functioning and people with oral cancer reporting higher levels of role or social functioning.
Conclusion
As survival is the main priority for most people diagnosed with cancer, pre-treatment HRQOL is an additional factor to be included in risk stratification and case-mix adjustments. There is merit in incorporating HRQOL into routine clinical care as this is a useful facet in patient-clinician decision making, prognostication and recovery.</description><subject>Carcinoma, Squamous Cell</subject><subject>Cognition</subject><subject>Head and Neck</subject><subject>Head and Neck Neoplasms - diagnosis</subject><subject>Head and Neck Neoplasms - therapy</subject><subject>Head and Neck Surgery</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurosurgery</subject><subject>Otorhinolaryngology</subject><subject>Prognosis</subject><subject>Quality of Life</subject><issn>0937-4477</issn><issn>1434-4726</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp9Uctu1DAUtRCITgs_wAJ5yYLAjV9JWCChilKkCoQEa8vjx4xLxh5sZ9T8Dx-K02kr2LDyse55XN2D0IsW3rQA3dsMwIA3QKAB3nNobh6hVcsoa1hHxGO0goF2DWNdd4JOc74GAM4G-hSdUAKCdIyu0O9vkxp9mXF0ePTOvsY6boIv_lDhfjtnr9WIVTDY7mLxMdSfm4JeIFYFG682IWaf8T5Z43XJeGuVuVUEq39irYK2CecpHfxBje_qRI3zIqiJWmWbsUtxh8vW4st75ZdFyeu-OJfJzM_QE6fGbJ_fvWfox8XH7-eXzdXXT5_PP1w1mjFRmoH2RoBZd8RVRKhojbOmZdw4ZvqeUD3w3raagCOacesYMcCF0INRa8YJPUPvj777ab2zRttQkhrlPvmdSrOMyst_J8Fv5SYeZNcKgKGtBq_uDFL8Ndlc5M5nbcdRBRunLAmtcSA6sWSRI1WnmHOy7iGmBbnUK4_1ylqvvK1X3lTRy78XfJDc91kJ9EjIdRQ2NsnrOKV68fw_2z-t07QF</recordid><startdate>20200501</startdate><enddate>20200501</enddate><creator>Rogers, S. N.</creator><creator>Waylen, A. E.</creator><creator>Thomas, S.</creator><creator>Penfold, C.</creator><creator>Pring, M.</creator><creator>Waterboer, T.</creator><creator>Pawlita, M.</creator><creator>Hurley, K.</creator><creator>Ness, A. R.</creator><general>Springer Berlin Heidelberg</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5989-6142</orcidid></search><sort><creationdate>20200501</creationdate><title>Quality of life, cognitive, physical and emotional function at diagnosis predicts head and neck cancer survival: analysis of cases from the Head and Neck 5000 study</title><author>Rogers, S. N. ; Waylen, A. E. ; Thomas, S. ; Penfold, C. ; Pring, M. ; Waterboer, T. ; Pawlita, M. ; Hurley, K. ; Ness, A. R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c446t-938d60db72f38d2361dfed145df4d8823c958e1c20f2c45ef42d0566c9dab4523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Carcinoma, Squamous Cell</topic><topic>Cognition</topic><topic>Head and Neck</topic><topic>Head and Neck Neoplasms - diagnosis</topic><topic>Head and Neck Neoplasms - therapy</topic><topic>Head and Neck Surgery</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurosurgery</topic><topic>Otorhinolaryngology</topic><topic>Prognosis</topic><topic>Quality of Life</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rogers, S. N.</creatorcontrib><creatorcontrib>Waylen, A. E.</creatorcontrib><creatorcontrib>Thomas, S.</creatorcontrib><creatorcontrib>Penfold, C.</creatorcontrib><creatorcontrib>Pring, M.</creatorcontrib><creatorcontrib>Waterboer, T.</creatorcontrib><creatorcontrib>Pawlita, M.</creatorcontrib><creatorcontrib>Hurley, K.</creatorcontrib><creatorcontrib>Ness, A. R.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European archives of oto-rhino-laryngology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rogers, S. N.</au><au>Waylen, A. E.</au><au>Thomas, S.</au><au>Penfold, C.</au><au>Pring, M.</au><au>Waterboer, T.</au><au>Pawlita, M.</au><au>Hurley, K.</au><au>Ness, A. R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quality of life, cognitive, physical and emotional function at diagnosis predicts head and neck cancer survival: analysis of cases from the Head and Neck 5000 study</atitle><jtitle>European archives of oto-rhino-laryngology</jtitle><stitle>Eur Arch Otorhinolaryngol</stitle><addtitle>Eur Arch Otorhinolaryngol</addtitle><date>2020-05-01</date><risdate>2020</risdate><volume>277</volume><issue>5</issue><spage>1515</spage><epage>1523</epage><pages>1515-1523</pages><issn>0937-4477</issn><eissn>1434-4726</eissn><abstract>Purpose
The aim of this paper is to determine whether health-related quality of life (HRQOL) at diagnosis of head and neck cancer (HNC) is associated with overall survival following treatment with curative intent after adjusting for other factors.
Methods
Data were collected from 5511 participants of the Head and Neck 5000 study (HN5000). HRQOL was measured using the EORTC QLQ-C30. Questionnaire and covariate data were available from 2171 participants diagnosed as follows: oral cavity (655), oropharynx HPV+ (723) and HPV− (277), and larynx (516). On average, participants were followed up 3.2 years (SD 1.2) after diagnosis. Data were adjusted for age, gender, co-morbidity, intended treatment, education level, income from benefits, smoking status and alcohol consumption.
Results
There was a clinically meaningful difference between Global HRQOL scores at diagnosis and survival in an unadjusted and adjusted model: [HR = 0.86, CI 0.82–0.89,
p
< 0.001 (unadjusted) and HR = 0.90, CI 0.86–0.94,
p
< 0.001 (adjusted)]. In analyses stratified by tumour site and HPV status, this association was similarly noted before adjustment and persisted after. There were some tumour sub-site variations: improved survival for people with laryngeal cancer reporting higher levels of physical role or social functioning and people with oral cancer reporting higher levels of role or social functioning.
Conclusion
As survival is the main priority for most people diagnosed with cancer, pre-treatment HRQOL is an additional factor to be included in risk stratification and case-mix adjustments. There is merit in incorporating HRQOL into routine clinical care as this is a useful facet in patient-clinician decision making, prognostication and recovery.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>32062743</pmid><doi>10.1007/s00405-020-05850-x</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-5989-6142</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0937-4477 |
| ispartof | European archives of oto-rhino-laryngology, 2020-05, Vol.277 (5), p.1515-1523 |
| issn | 0937-4477 1434-4726 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7160091 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Carcinoma, Squamous Cell Cognition Head and Neck Head and Neck Neoplasms - diagnosis Head and Neck Neoplasms - therapy Head and Neck Surgery Humans Medicine Medicine & Public Health Neurosurgery Otorhinolaryngology Prognosis Quality of Life |
| title | Quality of life, cognitive, physical and emotional function at diagnosis predicts head and neck cancer survival: analysis of cases from the Head and Neck 5000 study |
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