Enhancing Protein Backbone Binding-A Fruitful Concept for Combating Drug-Resistant HIV

The evolution of drug resistance is one of the most fundamental problems in medicine. In HIV/AIDS, the rapid emergence of drug‐resistant HIV‐1 variants is a major obstacle to current treatments. HIV‐1 protease inhibitors are essential components of present antiretroviral therapies. However, with the...

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Veröffentlicht in:	Angewandte Chemie International Edition 2012-02, Vol.51 (8), p.1778-1802
Hauptverfasser:	Ghosh, Arun K., Anderson, David D., Weber, Irene T., Mitsuya, Hiroaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome AIDS Antiretroviral agents antiviral agents Backbone backbone binding Drug resistance Drug Resistance, Viral Drugs Effectiveness Enzymes Evolution HIV HIV Infections - drug therapy HIV Infections - metabolism HIV Infections - virology HIV Protease Inhibitors - pharmacology HIV-1 - metabolism Human immunodeficiency virus Human immunodeficiency virus 1 Humans Inhibitors Protease inhibitors Protein Binding Proteinase inhibitors proteins Review Therapy
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