Methionine‐deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF‐I and insulin levels, and increases hepatocyte MIF levels and stress resistance
Summary A diet deficient in the amino acid methionine has previously been shown to extend lifespan in several stocks of inbred rats. We report here that a methionine‐deficient (Meth‐R) diet also increases maximal lifespan in (BALB/cJ × C57BL/6 J)F1 mice. Compared with controls, Meth‐R mice have sign...
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| Veröffentlicht in: | Aging cell 2005-06, Vol.4 (3), p.119-125 |
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| creator | Miller, Richard A. Buehner, Gretchen Chang, Yayi Harper, James M. Sigler, Robert Smith‐Wheelock, Michael |
| description | Summary
A diet deficient in the amino acid methionine has previously been shown to extend lifespan in several stocks of inbred rats. We report here that a methionine‐deficient (Meth‐R) diet also increases maximal lifespan in (BALB/cJ × C57BL/6 J)F1 mice. Compared with controls, Meth‐R mice have significantly lower levels of serum IGF‐I, insulin, glucose and thyroid hormone. Meth‐R mice also have higher levels of liver mRNA for MIF (macrophage migration inhibition factor), known to be higher in several other mouse models of extended longevity. Meth‐R mice are significantly slower to develop lens turbidity and to show age‐related changes in T‐cell subsets. They are also dramatically more resistant to oxidative liver cell injury induced by injection of toxic doses of acetaminophen. The spectrum of terminal illnesses in the Meth‐R group is similar to that seen in control mice. Studies of the cellular and molecular biology of methionine‐deprived mice may, in parallel to studies of calorie‐restricted mice, provide insights into the way in which nutritional factors modulate longevity and late‐life illnesses. |
| doi_str_mv | 10.1111/j.1474-9726.2005.00152.x |
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A diet deficient in the amino acid methionine has previously been shown to extend lifespan in several stocks of inbred rats. We report here that a methionine‐deficient (Meth‐R) diet also increases maximal lifespan in (BALB/cJ × C57BL/6 J)F1 mice. Compared with controls, Meth‐R mice have significantly lower levels of serum IGF‐I, insulin, glucose and thyroid hormone. Meth‐R mice also have higher levels of liver mRNA for MIF (macrophage migration inhibition factor), known to be higher in several other mouse models of extended longevity. Meth‐R mice are significantly slower to develop lens turbidity and to show age‐related changes in T‐cell subsets. They are also dramatically more resistant to oxidative liver cell injury induced by injection of toxic doses of acetaminophen. The spectrum of terminal illnesses in the Meth‐R group is similar to that seen in control mice. Studies of the cellular and molecular biology of methionine‐deprived mice may, in parallel to studies of calorie‐restricted mice, provide insights into the way in which nutritional factors modulate longevity and late‐life illnesses.</description><identifier>ISSN: 1474-9718</identifier><identifier>EISSN: 1474-9726</identifier><identifier>DOI: 10.1111/j.1474-9726.2005.00152.x</identifier><identifier>PMID: 15924568</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Acetaminophen - toxicity ; Aging - metabolism ; Alanine Transaminase - blood ; Animals ; biomarkers ; Blood Glucose - metabolism ; Body Weight ; Cataract - etiology ; Cataract - metabolism ; Diet ; Energy Intake ; Female ; Insulin - blood ; Insulin-Like Growth Factor I - metabolism ; Intramolecular Oxidoreductases ; L-Lactate Dehydrogenase - blood ; Liver - drug effects ; Liver - metabolism ; longevity ; Longevity - physiology ; Macrophage Migration-Inhibitory Factors - genetics ; Macrophage Migration-Inhibitory Factors - metabolism ; Methionine - deficiency ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; migration inhibition factor ; Original ; oxidative stress ; Oxidative Stress - drug effects ; RNA, Messenger - metabolism ; T-Lymphocyte Subsets - metabolism ; Thyroxine - blood</subject><ispartof>Aging cell, 2005-06, Vol.4 (3), p.119-125</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5382-985c05ab96826e1e7bf9b99b44b2a5999c96d5cabe6de3c694e4ccb773f4233b3</citedby><cites>FETCH-LOGICAL-c5382-985c05ab96826e1e7bf9b99b44b2a5999c96d5cabe6de3c694e4ccb773f4233b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1474-9726.2005.00152.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1474-9726.2005.00152.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,11541,27901,27902,45550,45551,46027,46451</link.rule.ids><linktorsrc>$$Uhttps://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1474-9726.2005.00152.x$$EView_record_in_Wiley-Blackwell$$FView_record_in_$$GWiley-Blackwell</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15924568$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miller, Richard A.</creatorcontrib><creatorcontrib>Buehner, Gretchen</creatorcontrib><creatorcontrib>Chang, Yayi</creatorcontrib><creatorcontrib>Harper, James M.</creatorcontrib><creatorcontrib>Sigler, Robert</creatorcontrib><creatorcontrib>Smith‐Wheelock, Michael</creatorcontrib><title>Methionine‐deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF‐I and insulin levels, and increases hepatocyte MIF levels and stress resistance</title><title>Aging cell</title><addtitle>Aging Cell</addtitle><description>Summary
A diet deficient in the amino acid methionine has previously been shown to extend lifespan in several stocks of inbred rats. We report here that a methionine‐deficient (Meth‐R) diet also increases maximal lifespan in (BALB/cJ × C57BL/6 J)F1 mice. Compared with controls, Meth‐R mice have significantly lower levels of serum IGF‐I, insulin, glucose and thyroid hormone. Meth‐R mice also have higher levels of liver mRNA for MIF (macrophage migration inhibition factor), known to be higher in several other mouse models of extended longevity. Meth‐R mice are significantly slower to develop lens turbidity and to show age‐related changes in T‐cell subsets. They are also dramatically more resistant to oxidative liver cell injury induced by injection of toxic doses of acetaminophen. The spectrum of terminal illnesses in the Meth‐R group is similar to that seen in control mice. Studies of the cellular and molecular biology of methionine‐deprived mice may, in parallel to studies of calorie‐restricted mice, provide insights into the way in which nutritional factors modulate longevity and late‐life illnesses.</description><subject>Acetaminophen - toxicity</subject><subject>Aging - metabolism</subject><subject>Alanine Transaminase - blood</subject><subject>Animals</subject><subject>biomarkers</subject><subject>Blood Glucose - metabolism</subject><subject>Body Weight</subject><subject>Cataract - etiology</subject><subject>Cataract - metabolism</subject><subject>Diet</subject><subject>Energy Intake</subject><subject>Female</subject><subject>Insulin - blood</subject><subject>Insulin-Like Growth Factor I - metabolism</subject><subject>Intramolecular Oxidoreductases</subject><subject>L-Lactate Dehydrogenase - blood</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>longevity</subject><subject>Longevity - physiology</subject><subject>Macrophage Migration-Inhibitory Factors - genetics</subject><subject>Macrophage Migration-Inhibitory Factors - metabolism</subject><subject>Methionine - deficiency</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Inbred C57BL</subject><subject>migration inhibition factor</subject><subject>Original</subject><subject>oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>RNA, Messenger - metabolism</subject><subject>T-Lymphocyte Subsets - metabolism</subject><subject>Thyroxine - blood</subject><issn>1474-9718</issn><issn>1474-9726</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1u2zAQhYmiQZOmvULBA8iqJFI_XLRAYMSpAQfZJGuCpEY2DYoyNFJi73KEnqfH6UlK_8Btd-GCHHC-9waYRwhNkzgN5-s6TnnJJ6LMijhLkjxOkjTP4u07cnVuvD_XaXVJPiKuA1SKhH0gl2kuMp4X1RX5dQ_Dynbeevj9-rOGxhoLfqC1hYHCdgBfI227EYE62wBulI8ouu4FqW3b0QNVvqYOPFK1tH4ZUeUG6JEu3Wg6hIg-8ojO72bBfX5grcfRWR80z-AwOv2ZHhQC0hVs1NCZ3QD0fj47QQcGhx4QabgsDsob-EQuGuUQPp_ea_I0u32c_pgsHu7m05vFxOSsyiaiyk2SKy2KKisghVI3QguhOdeZyoUQRhR1bpSGogZmCsGBG6PLkjU8Y0yza_L96LsZdQu1CevplZOb3raq38lOWfl_x9uVXHbPsgxrZkIEg-poYPoOsYfmrE0Tuc9TruU-KrmPTe7zlIc85TZIv_w7-6_wFGAAvh2BF-tg92ZjeTO9XYSK_QG6YrYN</recordid><startdate>200506</startdate><enddate>200506</enddate><creator>Miller, Richard A.</creator><creator>Buehner, Gretchen</creator><creator>Chang, Yayi</creator><creator>Harper, James M.</creator><creator>Sigler, Robert</creator><creator>Smith‐Wheelock, Michael</creator><general>Blackwell Science Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>200506</creationdate><title>Methionine‐deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF‐I and insulin levels, and increases hepatocyte MIF levels and stress resistance</title><author>Miller, Richard A. ; Buehner, Gretchen ; Chang, Yayi ; Harper, James M. ; Sigler, Robert ; Smith‐Wheelock, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5382-985c05ab96826e1e7bf9b99b44b2a5999c96d5cabe6de3c694e4ccb773f4233b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Acetaminophen - toxicity</topic><topic>Aging - metabolism</topic><topic>Alanine Transaminase - blood</topic><topic>Animals</topic><topic>biomarkers</topic><topic>Blood Glucose - metabolism</topic><topic>Body Weight</topic><topic>Cataract - etiology</topic><topic>Cataract - metabolism</topic><topic>Diet</topic><topic>Energy Intake</topic><topic>Female</topic><topic>Insulin - blood</topic><topic>Insulin-Like Growth Factor I - metabolism</topic><topic>Intramolecular Oxidoreductases</topic><topic>L-Lactate Dehydrogenase - blood</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>longevity</topic><topic>Longevity - physiology</topic><topic>Macrophage Migration-Inhibitory Factors - genetics</topic><topic>Macrophage Migration-Inhibitory Factors - metabolism</topic><topic>Methionine - deficiency</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Inbred C57BL</topic><topic>migration inhibition factor</topic><topic>Original</topic><topic>oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>RNA, Messenger - metabolism</topic><topic>T-Lymphocyte Subsets - metabolism</topic><topic>Thyroxine - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miller, Richard A.</creatorcontrib><creatorcontrib>Buehner, Gretchen</creatorcontrib><creatorcontrib>Chang, Yayi</creatorcontrib><creatorcontrib>Harper, James M.</creatorcontrib><creatorcontrib>Sigler, Robert</creatorcontrib><creatorcontrib>Smith‐Wheelock, Michael</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Aging cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Miller, Richard A.</au><au>Buehner, Gretchen</au><au>Chang, Yayi</au><au>Harper, James M.</au><au>Sigler, Robert</au><au>Smith‐Wheelock, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Methionine‐deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF‐I and insulin levels, and increases hepatocyte MIF levels and stress resistance</atitle><jtitle>Aging cell</jtitle><addtitle>Aging Cell</addtitle><date>2005-06</date><risdate>2005</risdate><volume>4</volume><issue>3</issue><spage>119</spage><epage>125</epage><pages>119-125</pages><issn>1474-9718</issn><eissn>1474-9726</eissn><abstract>Summary
A diet deficient in the amino acid methionine has previously been shown to extend lifespan in several stocks of inbred rats. We report here that a methionine‐deficient (Meth‐R) diet also increases maximal lifespan in (BALB/cJ × C57BL/6 J)F1 mice. Compared with controls, Meth‐R mice have significantly lower levels of serum IGF‐I, insulin, glucose and thyroid hormone. Meth‐R mice also have higher levels of liver mRNA for MIF (macrophage migration inhibition factor), known to be higher in several other mouse models of extended longevity. Meth‐R mice are significantly slower to develop lens turbidity and to show age‐related changes in T‐cell subsets. They are also dramatically more resistant to oxidative liver cell injury induced by injection of toxic doses of acetaminophen. The spectrum of terminal illnesses in the Meth‐R group is similar to that seen in control mice. Studies of the cellular and molecular biology of methionine‐deprived mice may, in parallel to studies of calorie‐restricted mice, provide insights into the way in which nutritional factors modulate longevity and late‐life illnesses.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>15924568</pmid><doi>10.1111/j.1474-9726.2005.00152.x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Aging cell, 2005-06, Vol.4 (3), p.119-125 |
| issn | 1474-9718 1474-9726 |
| language | eng |
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| source | Wiley-Blackwell Open Access Titles |
| subjects | Acetaminophen - toxicity Aging - metabolism Alanine Transaminase - blood Animals biomarkers Blood Glucose - metabolism Body Weight Cataract - etiology Cataract - metabolism Diet Energy Intake Female Insulin - blood Insulin-Like Growth Factor I - metabolism Intramolecular Oxidoreductases L-Lactate Dehydrogenase - blood Liver - drug effects Liver - metabolism longevity Longevity - physiology Macrophage Migration-Inhibitory Factors - genetics Macrophage Migration-Inhibitory Factors - metabolism Methionine - deficiency Mice Mice, Inbred BALB C Mice, Inbred C57BL migration inhibition factor Original oxidative stress Oxidative Stress - drug effects RNA, Messenger - metabolism T-Lymphocyte Subsets - metabolism Thyroxine - blood |
| title | Methionine‐deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF‐I and insulin levels, and increases hepatocyte MIF levels and stress resistance |
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