Viral dynamics in mild and severe cases of COVID-19
Patients who had any of the following features at the time of, or after, admission were classified as severe cases: (1) respiratory distress (≥30 breaths per min); (2) oxygen saturation at rest ≤93%; (3) ratio of partial pressure of arterial oxygen to fractional concentration of oxygen inspired air...
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| Veröffentlicht in: | The Lancet infectious diseases 2020-06, Vol.20 (6), p.656-657 |
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| container_title | The Lancet infectious diseases |
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| creator | Liu, Yang Yan, Li-Meng Wan, Lagen Xiang, Tian-Xin Le, Aiping Liu, Jia-Ming Peiris, Malik Poon, Leo L M Zhang, Wei |
| description | Patients who had any of the following features at the time of, or after, admission were classified as severe cases: (1) respiratory distress (≥30 breaths per min); (2) oxygen saturation at rest ≤93%; (3) ratio of partial pressure of arterial oxygen to fractional concentration of oxygen inspired air ≤300 mm Hg; or (4) severe disease complications (eg, respiratory failure, requirement of mechanical ventilation, septic shock, or non-respiratory organ failure). Parameters did not differ significantly between the groups, except that patients in the severe group were significantly older than those in the mild group, as expected.4 No patient died from the infection. 23 (77%) of 30 severe cases received intensive care unit (ICU) treatment, whereas none of the mild cases required ICU treatment. All samples were collected according to WHO guidelines.5 The mean viral load of severe cases was around 60 times higher than that of mild cases, suggesting that higher viral loads might be associated with severe clinical outcomes. |
| doi_str_mv | 10.1016/S1473-3099(20)30232-2 |
| format | Article |
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Parameters did not differ significantly between the groups, except that patients in the severe group were significantly older than those in the mild group, as expected.4 No patient died from the infection. 23 (77%) of 30 severe cases received intensive care unit (ICU) treatment, whereas none of the mild cases required ICU treatment. All samples were collected according to WHO guidelines.5 The mean viral load of severe cases was around 60 times higher than that of mild cases, suggesting that higher viral loads might be associated with severe clinical outcomes.</description><identifier>ISSN: 1473-3099</identifier><identifier>EISSN: 1474-4457</identifier><identifier>DOI: 10.1016/S1473-3099(20)30232-2</identifier><identifier>PMID: 32199493</identifier><language>eng</language><publisher>United States: Elsevier Ltd</publisher><subject>Adult ; Aged ; Betacoronavirus - pathogenicity ; Betacoronavirus - physiology ; Blood pressure ; China ; Coronavirus Infections - diagnosis ; Coronavirus Infections - virology ; Coronaviruses ; COVID-19 ; Female ; Health services ; Humans ; Infectious diseases ; Male ; Mechanical ventilation ; Middle Aged ; Oxygen ; Oxygen content ; Pandemics ; Partial pressure ; Patients ; Pneumonia, Viral - diagnosis ; Pneumonia, Viral - virology ; Respiratory organs ; RNA, Viral - isolation & purification ; SARS-CoV-2 ; Septic shock ; Severe acute respiratory syndrome coronavirus 2 ; Viral Load ; Virus Shedding</subject><ispartof>The Lancet infectious diseases, 2020-06, Vol.20 (6), p.656-657</ispartof><rights>2020 Elsevier Ltd</rights><rights>2020. Elsevier Ltd</rights><rights>2020 Elsevier Ltd. All rights reserved. 2020 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5562-3866333111ff85c23a979e50b98e9c0cc7b676011fe8fcf60f2b6489ab3036a3</citedby><cites>FETCH-LOGICAL-c5562-3866333111ff85c23a979e50b98e9c0cc7b676011fe8fcf60f2b6489ab3036a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1473309920302322$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32199493$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Yang</creatorcontrib><creatorcontrib>Yan, Li-Meng</creatorcontrib><creatorcontrib>Wan, Lagen</creatorcontrib><creatorcontrib>Xiang, Tian-Xin</creatorcontrib><creatorcontrib>Le, Aiping</creatorcontrib><creatorcontrib>Liu, Jia-Ming</creatorcontrib><creatorcontrib>Peiris, Malik</creatorcontrib><creatorcontrib>Poon, Leo L M</creatorcontrib><creatorcontrib>Zhang, Wei</creatorcontrib><title>Viral dynamics in mild and severe cases of COVID-19</title><title>The Lancet infectious diseases</title><addtitle>Lancet Infect Dis</addtitle><description>Patients who had any of the following features at the time of, or after, admission were classified as severe cases: (1) respiratory distress (≥30 breaths per min); (2) oxygen saturation at rest ≤93%; (3) ratio of partial pressure of arterial oxygen to fractional concentration of oxygen inspired air ≤300 mm Hg; or (4) severe disease complications (eg, respiratory failure, requirement of mechanical ventilation, septic shock, or non-respiratory organ failure). Parameters did not differ significantly between the groups, except that patients in the severe group were significantly older than those in the mild group, as expected.4 No patient died from the infection. 23 (77%) of 30 severe cases received intensive care unit (ICU) treatment, whereas none of the mild cases required ICU treatment. All samples were collected according to WHO guidelines.5 The mean viral load of severe cases was around 60 times higher than that of mild cases, suggesting that higher viral loads might be associated with severe clinical outcomes.</description><subject>Adult</subject><subject>Aged</subject><subject>Betacoronavirus - pathogenicity</subject><subject>Betacoronavirus - physiology</subject><subject>Blood pressure</subject><subject>China</subject><subject>Coronavirus Infections - diagnosis</subject><subject>Coronavirus Infections - virology</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>Female</subject><subject>Health services</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Mechanical ventilation</subject><subject>Middle Aged</subject><subject>Oxygen</subject><subject>Oxygen content</subject><subject>Pandemics</subject><subject>Partial pressure</subject><subject>Patients</subject><subject>Pneumonia, Viral - diagnosis</subject><subject>Pneumonia, Viral - virology</subject><subject>Respiratory organs</subject><subject>RNA, Viral - isolation & purification</subject><subject>SARS-CoV-2</subject><subject>Septic shock</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Viral Load</subject><subject>Virus Shedding</subject><issn>1473-3099</issn><issn>1474-4457</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkUtLAzEUhYMotlZ_gjLgpi5G85rMZKNIfRUKXVi6DZnMHU2ZR03aQv-96UNRN64Scr_ce-45CJ0TfE0wETevhKcsZljKPsVXDFNGY3qAuuGZx5wn6eH2vkM66MT7GcYkJZgfow6jREouWRexqXW6iop1o2trfGSbqLZVEemmiDyswEFktAcftWU0GE-HDzGRp-io1JWHs_3ZQ5Onx8ngJR6Nn4eD-1FskkTQmGVCMMYIIWWZJYYyLVMJCc5lBtJgY9JcpAKHMmSlKQUuaS54JnXOMBOa9dDtru18mddQGGgWQaqaO1trt1attup3pbHv6q1dqZQkmQyG9FB_38C1H0vwC1Vbb6CqdAPt0ivKMpJxQTkO6OUfdNYuXRO2U5TTRAQjpQhUsqOMa713UH6LIVhtUlHbVNTGckWx2qaiNkIufm7y_esrhgDc7QAIdq4sOOWNhcZAYR2YhSpa-8-ITwELmTc</recordid><startdate>20200601</startdate><enddate>20200601</enddate><creator>Liu, Yang</creator><creator>Yan, Li-Meng</creator><creator>Wan, Lagen</creator><creator>Xiang, Tian-Xin</creator><creator>Le, Aiping</creator><creator>Liu, Jia-Ming</creator><creator>Peiris, Malik</creator><creator>Poon, Leo L M</creator><creator>Zhang, Wei</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8C2</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200601</creationdate><title>Viral dynamics in mild and severe cases of COVID-19</title><author>Liu, Yang ; Yan, Li-Meng ; Wan, Lagen ; Xiang, Tian-Xin ; Le, Aiping ; Liu, Jia-Ming ; Peiris, Malik ; Poon, Leo L M ; Zhang, Wei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5562-3866333111ff85c23a979e50b98e9c0cc7b676011fe8fcf60f2b6489ab3036a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Betacoronavirus - pathogenicity</topic><topic>Betacoronavirus - physiology</topic><topic>Blood pressure</topic><topic>China</topic><topic>Coronavirus Infections - diagnosis</topic><topic>Coronavirus Infections - virology</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>Female</topic><topic>Health services</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Mechanical ventilation</topic><topic>Middle Aged</topic><topic>Oxygen</topic><topic>Oxygen content</topic><topic>Pandemics</topic><topic>Partial pressure</topic><topic>Patients</topic><topic>Pneumonia, Viral - diagnosis</topic><topic>Pneumonia, Viral - virology</topic><topic>Respiratory organs</topic><topic>RNA, Viral - isolation & purification</topic><topic>SARS-CoV-2</topic><topic>Septic shock</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><topic>Viral Load</topic><topic>Virus Shedding</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Yang</creatorcontrib><creatorcontrib>Yan, Li-Meng</creatorcontrib><creatorcontrib>Wan, Lagen</creatorcontrib><creatorcontrib>Xiang, Tian-Xin</creatorcontrib><creatorcontrib>Le, Aiping</creatorcontrib><creatorcontrib>Liu, Jia-Ming</creatorcontrib><creatorcontrib>Peiris, Malik</creatorcontrib><creatorcontrib>Poon, Leo L M</creatorcontrib><creatorcontrib>Zhang, Wei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Lancet Titles</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Lancet infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Yang</au><au>Yan, Li-Meng</au><au>Wan, Lagen</au><au>Xiang, Tian-Xin</au><au>Le, Aiping</au><au>Liu, Jia-Ming</au><au>Peiris, Malik</au><au>Poon, Leo L M</au><au>Zhang, Wei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Viral dynamics in mild and severe cases of COVID-19</atitle><jtitle>The Lancet infectious diseases</jtitle><addtitle>Lancet Infect Dis</addtitle><date>2020-06-01</date><risdate>2020</risdate><volume>20</volume><issue>6</issue><spage>656</spage><epage>657</epage><pages>656-657</pages><issn>1473-3099</issn><eissn>1474-4457</eissn><abstract>Patients who had any of the following features at the time of, or after, admission were classified as severe cases: (1) respiratory distress (≥30 breaths per min); (2) oxygen saturation at rest ≤93%; (3) ratio of partial pressure of arterial oxygen to fractional concentration of oxygen inspired air ≤300 mm Hg; or (4) severe disease complications (eg, respiratory failure, requirement of mechanical ventilation, septic shock, or non-respiratory organ failure). Parameters did not differ significantly between the groups, except that patients in the severe group were significantly older than those in the mild group, as expected.4 No patient died from the infection. 23 (77%) of 30 severe cases received intensive care unit (ICU) treatment, whereas none of the mild cases required ICU treatment. All samples were collected according to WHO guidelines.5 The mean viral load of severe cases was around 60 times higher than that of mild cases, suggesting that higher viral loads might be associated with severe clinical outcomes.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>32199493</pmid><doi>10.1016/S1473-3099(20)30232-2</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1473-3099 |
| ispartof | The Lancet infectious diseases, 2020-06, Vol.20 (6), p.656-657 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Aged Betacoronavirus - pathogenicity Betacoronavirus - physiology Blood pressure China Coronavirus Infections - diagnosis Coronavirus Infections - virology Coronaviruses COVID-19 Female Health services Humans Infectious diseases Male Mechanical ventilation Middle Aged Oxygen Oxygen content Pandemics Partial pressure Patients Pneumonia, Viral - diagnosis Pneumonia, Viral - virology Respiratory organs RNA, Viral - isolation & purification SARS-CoV-2 Septic shock Severe acute respiratory syndrome coronavirus 2 Viral Load Virus Shedding |
| title | Viral dynamics in mild and severe cases of COVID-19 |
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