CpG Dinucleotides Inhibit HIV-1 Replication through Zinc Finger Antiviral Protein (ZAP)-Dependent and -Independent Mechanisms

CpG dinucleotides are suppressed in the genomes of many vertebrate RNA viruses, including HIV-1. The cellular antiviral protein ZAP (zinc finger antiviral protein) binds CpGs and inhibits HIV-1 replication when CpGs are introduced into the viral genome. However, it is not known if ZAP-mediated restr...

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Veröffentlicht in:	Journal of virology 2020-02, Vol.94 (6)
Hauptverfasser:	Ficarelli, Mattia, Antzin-Anduetza, Irati, Hugh-White, Rupert, Firth, Andrew E, Sertkaya, Helin, Wilson, Harry, Neil, Stuart J D, Schulz, Reiner, Swanson, Chad M
Format:	Artikel
Sprache:	eng
Schlagworte:	Dinucleoside Phosphates - genetics Dinucleoside Phosphates - metabolism Gene Expression Regulation, Viral - physiology HEK293 Cells HIV-1 - physiology Humans Muramidase Peptide Fragments RNA, Viral - genetics RNA, Viral - metabolism RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Virus Replication - physiology Virus-Cell Interactions
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