Altered organization of collagen fibers in the uninvolved human colon mucosa 10 cm and 20 cm away from the malignant tumor
Remodelling of collagen fibers has been described during every phase of cancer genesis and progression. Changes in morphology and organization of collagen fibers contribute to the formation of microenvironment that favors cancer progression and development of metastasis. However, there are only few...
Gespeichert in:
| Veröffentlicht in: | Scientific reports 2020-04, Vol.10 (1), p.6359-6359, Article 6359 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 6359 |
|---|---|
| container_issue | 1 |
| container_start_page | 6359 |
| container_title | Scientific reports |
| container_volume | 10 |
| creator | Despotović, Sanja Z. Milićević, Đorđe N. Krmpot, Aleksandar J. Pavlović, Aleksandra M. Živanović, Vladimir D. Krivokapić, Zoran Pavlović, Vladimir B. Lević, Steva Nikolić, Gorana Rabasović, Mihailo D. |
| description | Remodelling of collagen fibers has been described during every phase of cancer genesis and progression. Changes in morphology and organization of collagen fibers contribute to the formation of microenvironment that favors cancer progression and development of metastasis. However, there are only few data about remodelling of collagen fibers in healthy looking mucosa distant from the cancer. Using SHG imaging, electron microscopy and specialized softwares (CT-FIRE, CurveAlign and FiberFit), we objectively visualized and quantified changes in morphology and organization of collagen fibers and investigated possible causes of collagen remodelling (change in syntheses, degradation and collagen cross-linking) in the colon mucosa 10 cm and 20 cm away from the cancer in comparison with healthy mucosa. We showed that in the lamina propria this far from the colon cancer, there were changes in collagen architecture (width, straightness, alignment of collagen fibers and collagen molecules inside fibers), increased representation of myofibroblasts and increase expression of collagen-remodelling enzymes (LOX and MMP2). Thus, the changes in organization of collagen fibers, which were already described in the cancer microenvironment, also exist in the mucosa far from the cancer, but smaller in magnitude. |
| doi_str_mv | 10.1038/s41598-020-63368-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7156654</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2389699387</sourcerecordid><originalsourceid>FETCH-LOGICAL-c540t-bddcf568e4177d8da6cedda3aa8330626eda0686e303fd0ed59e0ee38945f4b63</originalsourceid><addsrcrecordid>eNp9kU1vFSEUhonR2Kb2D7gwJG7cjGX4GmZj0jR-JU260TXhwpm5NANUmLnmujBu_Zv-EmmnrdWFbCCc530Phxeh5y153RKmTgpvRa8aQkkjGZOq2T9Ch5Rw0VBG6eMH5wN0XMolqUvQnrf9U3RQb5XknB2i76fTDBkcTnk00X8zs08RpwHbNE1mhIgHv4FcsI943gJeoo-7NO2qYrsEE6-5KgiLTcXglvz68dMGbKLD9O781ezxkFO40Qcz-TGaOON5CSk_Q08GMxU4vt2P0Od3bz-dfWjOL95_PDs9b6zgZG42ztlBSAW87TqnnJEWnDPMGMUYkVSCM0QqCYywwRFwogcCwFTPxcA3kh2hN6vv1bIJ4CzEOZtJX2UfTN7rZLz-uxL9Vo9pp7tWSCl4NXh1a5DTlwXKrIMvFuofRUhL0bT2kh1nTFX05T_oZVpyrOOtVN8z1VWKrpTNqZQMw_1jWqKvE9ZrwromrG8S1vsqevFwjHvJXZ4VYCtQaimOkP_0_o_tb90fth4</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2389699387</pqid></control><display><type>article</type><title>Altered organization of collagen fibers in the uninvolved human colon mucosa 10 cm and 20 cm away from the malignant tumor</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Nature Free</source><source>PubMed Central</source><source>Springer Nature OA/Free Journals</source><source>Free Full-Text Journals in Chemistry</source><creator>Despotović, Sanja Z. ; Milićević, Đorđe N. ; Krmpot, Aleksandar J. ; Pavlović, Aleksandra M. ; Živanović, Vladimir D. ; Krivokapić, Zoran ; Pavlović, Vladimir B. ; Lević, Steva ; Nikolić, Gorana ; Rabasović, Mihailo D.</creator><creatorcontrib>Despotović, Sanja Z. ; Milićević, Đorđe N. ; Krmpot, Aleksandar J. ; Pavlović, Aleksandra M. ; Živanović, Vladimir D. ; Krivokapić, Zoran ; Pavlović, Vladimir B. ; Lević, Steva ; Nikolić, Gorana ; Rabasović, Mihailo D.</creatorcontrib><description>Remodelling of collagen fibers has been described during every phase of cancer genesis and progression. Changes in morphology and organization of collagen fibers contribute to the formation of microenvironment that favors cancer progression and development of metastasis. However, there are only few data about remodelling of collagen fibers in healthy looking mucosa distant from the cancer. Using SHG imaging, electron microscopy and specialized softwares (CT-FIRE, CurveAlign and FiberFit), we objectively visualized and quantified changes in morphology and organization of collagen fibers and investigated possible causes of collagen remodelling (change in syntheses, degradation and collagen cross-linking) in the colon mucosa 10 cm and 20 cm away from the cancer in comparison with healthy mucosa. We showed that in the lamina propria this far from the colon cancer, there were changes in collagen architecture (width, straightness, alignment of collagen fibers and collagen molecules inside fibers), increased representation of myofibroblasts and increase expression of collagen-remodelling enzymes (LOX and MMP2). Thus, the changes in organization of collagen fibers, which were already described in the cancer microenvironment, also exist in the mucosa far from the cancer, but smaller in magnitude.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-63368-y</identifier><identifier>PMID: 32286443</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/67 ; 692/308 ; 692/4017 ; 692/4020 ; 692/420 ; Aged ; Cancer ; Collagen ; Collagen - metabolism ; Collagen - ultrastructure ; Colon ; Colon - metabolism ; Colon - ultrastructure ; Colon cancer ; Colonic Neoplasms - genetics ; Colonic Neoplasms - metabolism ; Colonic Neoplasms - pathology ; Colonic Neoplasms - ultrastructure ; Colorectal cancer ; Computed tomography ; Cross-linking ; Disease Progression ; Electron microscopy ; Extracellular Matrix - pathology ; Extracellular Matrix - ultrastructure ; Female ; Fibers ; Gelatinase A ; Gene Expression Regulation, Neoplastic - genetics ; Humanities and Social Sciences ; Humans ; Intestinal Mucosa - pathology ; Intestinal Mucosa - ultrastructure ; Lamina propria ; Male ; Matrix Metalloproteinase 2 - genetics ; Metastases ; Microscopy, Electron ; Morphology ; Mucosa ; multidisciplinary ; Protein-Lysine 6-Oxidase - genetics ; Science ; Science (multidisciplinary) ; Software ; Tumor Microenvironment - genetics</subject><ispartof>Scientific reports, 2020-04, Vol.10 (1), p.6359-6359, Article 6359</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-bddcf568e4177d8da6cedda3aa8330626eda0686e303fd0ed59e0ee38945f4b63</citedby><cites>FETCH-LOGICAL-c540t-bddcf568e4177d8da6cedda3aa8330626eda0686e303fd0ed59e0ee38945f4b63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156654/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156654/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32286443$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Despotović, Sanja Z.</creatorcontrib><creatorcontrib>Milićević, Đorđe N.</creatorcontrib><creatorcontrib>Krmpot, Aleksandar J.</creatorcontrib><creatorcontrib>Pavlović, Aleksandra M.</creatorcontrib><creatorcontrib>Živanović, Vladimir D.</creatorcontrib><creatorcontrib>Krivokapić, Zoran</creatorcontrib><creatorcontrib>Pavlović, Vladimir B.</creatorcontrib><creatorcontrib>Lević, Steva</creatorcontrib><creatorcontrib>Nikolić, Gorana</creatorcontrib><creatorcontrib>Rabasović, Mihailo D.</creatorcontrib><title>Altered organization of collagen fibers in the uninvolved human colon mucosa 10 cm and 20 cm away from the malignant tumor</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Remodelling of collagen fibers has been described during every phase of cancer genesis and progression. Changes in morphology and organization of collagen fibers contribute to the formation of microenvironment that favors cancer progression and development of metastasis. However, there are only few data about remodelling of collagen fibers in healthy looking mucosa distant from the cancer. Using SHG imaging, electron microscopy and specialized softwares (CT-FIRE, CurveAlign and FiberFit), we objectively visualized and quantified changes in morphology and organization of collagen fibers and investigated possible causes of collagen remodelling (change in syntheses, degradation and collagen cross-linking) in the colon mucosa 10 cm and 20 cm away from the cancer in comparison with healthy mucosa. We showed that in the lamina propria this far from the colon cancer, there were changes in collagen architecture (width, straightness, alignment of collagen fibers and collagen molecules inside fibers), increased representation of myofibroblasts and increase expression of collagen-remodelling enzymes (LOX and MMP2). Thus, the changes in organization of collagen fibers, which were already described in the cancer microenvironment, also exist in the mucosa far from the cancer, but smaller in magnitude.</description><subject>631/67</subject><subject>692/308</subject><subject>692/4017</subject><subject>692/4020</subject><subject>692/420</subject><subject>Aged</subject><subject>Cancer</subject><subject>Collagen</subject><subject>Collagen - metabolism</subject><subject>Collagen - ultrastructure</subject><subject>Colon</subject><subject>Colon - metabolism</subject><subject>Colon - ultrastructure</subject><subject>Colon cancer</subject><subject>Colonic Neoplasms - genetics</subject><subject>Colonic Neoplasms - metabolism</subject><subject>Colonic Neoplasms - pathology</subject><subject>Colonic Neoplasms - ultrastructure</subject><subject>Colorectal cancer</subject><subject>Computed tomography</subject><subject>Cross-linking</subject><subject>Disease Progression</subject><subject>Electron microscopy</subject><subject>Extracellular Matrix - pathology</subject><subject>Extracellular Matrix - ultrastructure</subject><subject>Female</subject><subject>Fibers</subject><subject>Gelatinase A</subject><subject>Gene Expression Regulation, Neoplastic - genetics</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Intestinal Mucosa - pathology</subject><subject>Intestinal Mucosa - ultrastructure</subject><subject>Lamina propria</subject><subject>Male</subject><subject>Matrix Metalloproteinase 2 - genetics</subject><subject>Metastases</subject><subject>Microscopy, Electron</subject><subject>Morphology</subject><subject>Mucosa</subject><subject>multidisciplinary</subject><subject>Protein-Lysine 6-Oxidase - genetics</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Software</subject><subject>Tumor Microenvironment - genetics</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU1vFSEUhonR2Kb2D7gwJG7cjGX4GmZj0jR-JU260TXhwpm5NANUmLnmujBu_Zv-EmmnrdWFbCCc530Phxeh5y153RKmTgpvRa8aQkkjGZOq2T9Ch5Rw0VBG6eMH5wN0XMolqUvQnrf9U3RQb5XknB2i76fTDBkcTnk00X8zs08RpwHbNE1mhIgHv4FcsI943gJeoo-7NO2qYrsEE6-5KgiLTcXglvz68dMGbKLD9O781ezxkFO40Qcz-TGaOON5CSk_Q08GMxU4vt2P0Od3bz-dfWjOL95_PDs9b6zgZG42ztlBSAW87TqnnJEWnDPMGMUYkVSCM0QqCYywwRFwogcCwFTPxcA3kh2hN6vv1bIJ4CzEOZtJX2UfTN7rZLz-uxL9Vo9pp7tWSCl4NXh1a5DTlwXKrIMvFuofRUhL0bT2kh1nTFX05T_oZVpyrOOtVN8z1VWKrpTNqZQMw_1jWqKvE9ZrwromrG8S1vsqevFwjHvJXZ4VYCtQaimOkP_0_o_tb90fth4</recordid><startdate>20200414</startdate><enddate>20200414</enddate><creator>Despotović, Sanja Z.</creator><creator>Milićević, Đorđe N.</creator><creator>Krmpot, Aleksandar J.</creator><creator>Pavlović, Aleksandra M.</creator><creator>Živanović, Vladimir D.</creator><creator>Krivokapić, Zoran</creator><creator>Pavlović, Vladimir B.</creator><creator>Lević, Steva</creator><creator>Nikolić, Gorana</creator><creator>Rabasović, Mihailo D.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200414</creationdate><title>Altered organization of collagen fibers in the uninvolved human colon mucosa 10 cm and 20 cm away from the malignant tumor</title><author>Despotović, Sanja Z. ; Milićević, Đorđe N. ; Krmpot, Aleksandar J. ; Pavlović, Aleksandra M. ; Živanović, Vladimir D. ; Krivokapić, Zoran ; Pavlović, Vladimir B. ; Lević, Steva ; Nikolić, Gorana ; Rabasović, Mihailo D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c540t-bddcf568e4177d8da6cedda3aa8330626eda0686e303fd0ed59e0ee38945f4b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>631/67</topic><topic>692/308</topic><topic>692/4017</topic><topic>692/4020</topic><topic>692/420</topic><topic>Aged</topic><topic>Cancer</topic><topic>Collagen</topic><topic>Collagen - metabolism</topic><topic>Collagen - ultrastructure</topic><topic>Colon</topic><topic>Colon - metabolism</topic><topic>Colon - ultrastructure</topic><topic>Colon cancer</topic><topic>Colonic Neoplasms - genetics</topic><topic>Colonic Neoplasms - metabolism</topic><topic>Colonic Neoplasms - pathology</topic><topic>Colonic Neoplasms - ultrastructure</topic><topic>Colorectal cancer</topic><topic>Computed tomography</topic><topic>Cross-linking</topic><topic>Disease Progression</topic><topic>Electron microscopy</topic><topic>Extracellular Matrix - pathology</topic><topic>Extracellular Matrix - ultrastructure</topic><topic>Female</topic><topic>Fibers</topic><topic>Gelatinase A</topic><topic>Gene Expression Regulation, Neoplastic - genetics</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Intestinal Mucosa - pathology</topic><topic>Intestinal Mucosa - ultrastructure</topic><topic>Lamina propria</topic><topic>Male</topic><topic>Matrix Metalloproteinase 2 - genetics</topic><topic>Metastases</topic><topic>Microscopy, Electron</topic><topic>Morphology</topic><topic>Mucosa</topic><topic>multidisciplinary</topic><topic>Protein-Lysine 6-Oxidase - genetics</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Software</topic><topic>Tumor Microenvironment - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Despotović, Sanja Z.</creatorcontrib><creatorcontrib>Milićević, Đorđe N.</creatorcontrib><creatorcontrib>Krmpot, Aleksandar J.</creatorcontrib><creatorcontrib>Pavlović, Aleksandra M.</creatorcontrib><creatorcontrib>Živanović, Vladimir D.</creatorcontrib><creatorcontrib>Krivokapić, Zoran</creatorcontrib><creatorcontrib>Pavlović, Vladimir B.</creatorcontrib><creatorcontrib>Lević, Steva</creatorcontrib><creatorcontrib>Nikolić, Gorana</creatorcontrib><creatorcontrib>Rabasović, Mihailo D.</creatorcontrib><collection>Springer Nature OA/Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Despotović, Sanja Z.</au><au>Milićević, Đorđe N.</au><au>Krmpot, Aleksandar J.</au><au>Pavlović, Aleksandra M.</au><au>Živanović, Vladimir D.</au><au>Krivokapić, Zoran</au><au>Pavlović, Vladimir B.</au><au>Lević, Steva</au><au>Nikolić, Gorana</au><au>Rabasović, Mihailo D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Altered organization of collagen fibers in the uninvolved human colon mucosa 10 cm and 20 cm away from the malignant tumor</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2020-04-14</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>6359</spage><epage>6359</epage><pages>6359-6359</pages><artnum>6359</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Remodelling of collagen fibers has been described during every phase of cancer genesis and progression. Changes in morphology and organization of collagen fibers contribute to the formation of microenvironment that favors cancer progression and development of metastasis. However, there are only few data about remodelling of collagen fibers in healthy looking mucosa distant from the cancer. Using SHG imaging, electron microscopy and specialized softwares (CT-FIRE, CurveAlign and FiberFit), we objectively visualized and quantified changes in morphology and organization of collagen fibers and investigated possible causes of collagen remodelling (change in syntheses, degradation and collagen cross-linking) in the colon mucosa 10 cm and 20 cm away from the cancer in comparison with healthy mucosa. We showed that in the lamina propria this far from the colon cancer, there were changes in collagen architecture (width, straightness, alignment of collagen fibers and collagen molecules inside fibers), increased representation of myofibroblasts and increase expression of collagen-remodelling enzymes (LOX and MMP2). Thus, the changes in organization of collagen fibers, which were already described in the cancer microenvironment, also exist in the mucosa far from the cancer, but smaller in magnitude.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32286443</pmid><doi>10.1038/s41598-020-63368-y</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2045-2322 |
| ispartof | Scientific reports, 2020-04, Vol.10 (1), p.6359-6359, Article 6359 |
| issn | 2045-2322 2045-2322 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7156654 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Nature Free; PubMed Central; Springer Nature OA/Free Journals; Free Full-Text Journals in Chemistry |
| subjects | 631/67 692/308 692/4017 692/4020 692/420 Aged Cancer Collagen Collagen - metabolism Collagen - ultrastructure Colon Colon - metabolism Colon - ultrastructure Colon cancer Colonic Neoplasms - genetics Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Colonic Neoplasms - ultrastructure Colorectal cancer Computed tomography Cross-linking Disease Progression Electron microscopy Extracellular Matrix - pathology Extracellular Matrix - ultrastructure Female Fibers Gelatinase A Gene Expression Regulation, Neoplastic - genetics Humanities and Social Sciences Humans Intestinal Mucosa - pathology Intestinal Mucosa - ultrastructure Lamina propria Male Matrix Metalloproteinase 2 - genetics Metastases Microscopy, Electron Morphology Mucosa multidisciplinary Protein-Lysine 6-Oxidase - genetics Science Science (multidisciplinary) Software Tumor Microenvironment - genetics |
| title | Altered organization of collagen fibers in the uninvolved human colon mucosa 10 cm and 20 cm away from the malignant tumor |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-21T05%3A53%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Altered%20organization%20of%20collagen%20fibers%20in%20the%20uninvolved%20human%20colon%20mucosa%2010%E2%80%89cm%20and%2020%E2%80%89cm%20away%20from%20the%20malignant%20tumor&rft.jtitle=Scientific%20reports&rft.au=Despotovi%C4%87,%20Sanja%20Z.&rft.date=2020-04-14&rft.volume=10&rft.issue=1&rft.spage=6359&rft.epage=6359&rft.pages=6359-6359&rft.artnum=6359&rft.issn=2045-2322&rft.eissn=2045-2322&rft_id=info:doi/10.1038/s41598-020-63368-y&rft_dat=%3Cproquest_pubme%3E2389699387%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2389699387&rft_id=info:pmid/32286443&rfr_iscdi=true |