Preclinical evaluation of efficacy and pharmacokinetics of gentamicin containing extracellular‐matrix envelope

Background Using synthetic antibiotic‐eluting envelope (ABE) is an effective intervention for prevention of cardiovascular implantable electronic device (CIED) infection. The biologic extracellular‐matrix envelope (ECME), may offer potential advantages over the synthetic ABE. To further minimize the...

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Veröffentlicht in:	Pacing and clinical electrophysiology 2020-03, Vol.43 (3), p.341-349
Hauptverfasser:	Sohail, M. Rizwan, Esquer Garrigos, Zerelda, Elayi, Claude S., Xiang, Kun, Catanzaro, John N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - pharmacokinetics Bacteria CIED pocket infection Devices Disease Models, Animal efficacy Extracellular Matrix Gentamicin gentamicin extracellular matrix envelope Gentamicins - administration & dosage Gentamicins - pharmacokinetics Infections Pacemaker, Artificial Pharmacokinetics prevention Prosthesis-Related Infections - microbiology Prosthesis-Related Infections - prevention & control Rabbits Statistical analysis Stem Cells
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