Decoupling of Apoptosis from Activation of the ER Stress Response by the Drosophila Metallopeptidase superdeath

Abstract Genetic diseases display a great deal of variability in patient outcomes, much of which is caused by differences in genetic background. The endoplasmic reticulum (ER) stress response commonly modifies degenerative disease... Endoplasmic reticulum (ER) stress-induced apoptosis is a primary c...

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Veröffentlicht in:	Genetics (Austin) 2020-04, Vol.214 (4), p.913-925
Hauptverfasser:	Palu, Rebecca A S, Dalton, Hans M, Chow, Clement Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Alzheimer's disease Animals Apoptosis Cellular stress response Cyclin-dependent kinase 5 Cyclin-Dependent Kinase 5 - genetics Decoupling Degeneration Drosophila melanogaster Drosophila Proteins - genetics Drosophila Proteins - metabolism Endoplasmic reticulum Endoplasmic Reticulum Stress Epistasis, Genetic Genetic disorders Genetic diversity Genetics Insects Investigations Localization Membranes Metalloproteinase N-Acetylgalactosaminyltransferases - genetics N-Acetylgalactosaminyltransferases - metabolism Protein folding Proteins Transcription factors Unfolded Protein Response
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