Hematopoiesis and Cardiovascular Disease
A central feature of atherosclerosis, the most prevalent chronic vascular disease and root cause of myocardial infarction and stroke, is leukocyte accumulation in the arterial wall. These crucial immune cells are produced in specialized niches in the bone marrow, where a complex cell network orchest...
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| Veröffentlicht in: | Circulation research 2020-04, Vol.126 (8), p.1061-1085 |
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| container_end_page | 1085 |
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| container_issue | 8 |
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| container_title | Circulation research |
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| creator | Poller, Wolfram C. Nahrendorf, Matthias Swirski, Filip K. |
| description | A central feature of atherosclerosis, the most prevalent chronic vascular disease and root cause of myocardial infarction and stroke, is leukocyte accumulation in the arterial wall. These crucial immune cells are produced in specialized niches in the bone marrow, where a complex cell network orchestrates their production and release. A growing body of clinical studies has documented a correlation between leukocyte numbers and cardiovascular disease risk. Understanding how leukocytes are produced and how they contribute to atherosclerosis and its complications is, therefore, critical to understanding and treating the disease. In this review, we focus on the key cells and products that regulate hematopoiesis under homeostatic conditions, during atherosclerosis and after myocardial infarction. |
| doi_str_mv | 10.1161/CIRCRESAHA.120.315895 |
| format | Article |
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In this review, we focus on the key cells and products that regulate hematopoiesis under homeostatic conditions, during atherosclerosis and after myocardial infarction.</description><identifier>ISSN: 0009-7330</identifier><identifier>EISSN: 1524-4571</identifier><identifier>DOI: 10.1161/CIRCRESAHA.120.315895</identifier><identifier>PMID: 32271679</identifier><language>eng</language><publisher>United States: American Heart Association, Inc</publisher><subject>Animals ; Atherosclerosis - immunology ; Atherosclerosis - metabolism ; Atherosclerosis - pathology ; Cardiovascular Diseases - immunology ; Cardiovascular Diseases - metabolism ; Cardiovascular Diseases - pathology ; Endothelium, Vascular - immunology ; Endothelium, Vascular - metabolism ; Endothelium, Vascular - pathology ; Hematopoiesis - physiology ; Humans ; Leukocytes - immunology ; Leukocytes - metabolism ; Leukocytes - pathology</subject><ispartof>Circulation research, 2020-04, Vol.126 (8), p.1061-1085</ispartof><rights>American Heart Association, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5744-8e22b8538efae2a59798e21e8d706ce577dae0de539fc4f626b0ec2a339c63d43</citedby><cites>FETCH-LOGICAL-c5744-8e22b8538efae2a59798e21e8d706ce577dae0de539fc4f626b0ec2a339c63d43</cites><orcidid>0000-0002-3163-9152</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,3687,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32271679$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Poller, Wolfram C.</creatorcontrib><creatorcontrib>Nahrendorf, Matthias</creatorcontrib><creatorcontrib>Swirski, Filip K.</creatorcontrib><title>Hematopoiesis and Cardiovascular Disease</title><title>Circulation research</title><addtitle>Circ Res</addtitle><description>A central feature of atherosclerosis, the most prevalent chronic vascular disease and root cause of myocardial infarction and stroke, is leukocyte accumulation in the arterial wall. 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| source | MEDLINE; American Heart Association Journals; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Atherosclerosis - immunology Atherosclerosis - metabolism Atherosclerosis - pathology Cardiovascular Diseases - immunology Cardiovascular Diseases - metabolism Cardiovascular Diseases - pathology Endothelium, Vascular - immunology Endothelium, Vascular - metabolism Endothelium, Vascular - pathology Hematopoiesis - physiology Humans Leukocytes - immunology Leukocytes - metabolism Leukocytes - pathology |
| title | Hematopoiesis and Cardiovascular Disease |
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