Catching a Moving Target: Comparative Modeling of Flaviviral NS2B-NS3 Reveals Small Molecule Zika Protease Inhibitors

The pivotal role of viral proteases in virus replication has already been successfully exploited in several antiviral drug design campaigns. However, no efficient antivirals are currently available against flaviviral infections. In this study, we present lead-like small molecule inhibitors of the Zi...

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Veröffentlicht in:	ACS medicinal chemistry letters 2020-04, Vol.11 (4), p.514-520
Hauptverfasser:	Pach, Szymon, Sarter, Tim M, Yousef, Rafe, Schaller, David, Bergemann, Silke, Arkona, Christoph, Rademann, Jörg, Nitsche, Christoph, Wolber, Gerhard
Format:	Artikel
Sprache:	eng
Schlagworte:	Letter
Online-Zugang:	Volltext
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