Long non-coding RNAs in immune regulation and their potential as therapeutic targets
•More than 97% of transcripts in the cell are categorized as non-coding RNAs.•Long non-coding RNAs (lncRNAs) outnumber protein coding genes.•lncRNAs are often expressed in a tissue-, cell type-, and disease-specific manner.•lncRNAs play known roles in virtually all major subclasses of immune cells.•...
Gespeichert in:
| Veröffentlicht in: | International immunopharmacology 2020-04, Vol.81, p.106279-106279, Article 106279 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 106279 |
|---|---|
| container_issue | |
| container_start_page | 106279 |
| container_title | International immunopharmacology |
| container_volume | 81 |
| creator | Uthaya Kumar, Dinesh Babu Williams, Adam |
| description | •More than 97% of transcripts in the cell are categorized as non-coding RNAs.•Long non-coding RNAs (lncRNAs) outnumber protein coding genes.•lncRNAs are often expressed in a tissue-, cell type-, and disease-specific manner.•lncRNAs play known roles in virtually all major subclasses of immune cells.•lncRNAs are implicated in multiple immunologic disorders.
Long non-coding RNAs (lncRNAs) are potent regulators of immune cell development and function. Their implication in multiple immune-mediated disorders highlights lncRNAs as exciting biomarkers and potential drug targets. Recent technological innovations in oligo-based therapeutics, development of RNA-targeting small molecules, and CRISPR-based approaches, position RNA as the next therapeutic frontier. Here, we review the latest advances made toward understanding the role of lncRNAs in human immunological disorders and further discuss RNA-targeting approaches that could be potentially exploited to manipulate lncRNA function as a clinical intervention. |
| doi_str_mv | 10.1016/j.intimp.2020.106279 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7150622</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1567576919329170</els_id><sourcerecordid>2355977072</sourcerecordid><originalsourceid>FETCH-LOGICAL-c491t-c26ba0752bc6667c532e4b86c43f7afa59ba2e6f69e76a928a0e1b4c71e8bfc83</originalsourceid><addsrcrecordid>eNp9UcuKFTEQDaI44-gfiATcuOlrks6jsxGGYXzARUHGdUinq-_k0p20SXrAvzfNHcfHwlWKk1On6tRB6CUlO0qofHvc-VD8vOwYYRskmdKP0DntVNdQRcTjWgupGqGkPkPPcj4SUnFOn6KzlhHRaabP0c0-hgMOMTQuDr6WXz9fZuwD9vO8BsAJDutki48B2zDgcgs-4SUWqLPthG3eoGQXWIt3uNh0gJKfoyejnTK8uH8v0Lf31zdXH5v9lw-fri73jeOalsYx2VuiBOudlFI50TLgfScdb0dlRyt0bxnIUWpQ0mrWWQK0505R6PrRde0FenfSXdZ-hsHVpZKdzJL8bNMPE603f_8Ef2sO8c4oKuq9WBV4cy-Q4vcVcjGzzw6myQaIazasFUIrRdRGff0P9RjXFKo9wzgnXBNNZWXxE8ulmHOC8WEZSswWmzmaU2xmi82cYqttr_408tD0K6ffTqGe885DMtl5CA4Gn8AVM0T__wk_AcbjrDg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2440490916</pqid></control><display><type>article</type><title>Long non-coding RNAs in immune regulation and their potential as therapeutic targets</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Uthaya Kumar, Dinesh Babu ; Williams, Adam</creator><creatorcontrib>Uthaya Kumar, Dinesh Babu ; Williams, Adam</creatorcontrib><description>•More than 97% of transcripts in the cell are categorized as non-coding RNAs.•Long non-coding RNAs (lncRNAs) outnumber protein coding genes.•lncRNAs are often expressed in a tissue-, cell type-, and disease-specific manner.•lncRNAs play known roles in virtually all major subclasses of immune cells.•lncRNAs are implicated in multiple immunologic disorders.
Long non-coding RNAs (lncRNAs) are potent regulators of immune cell development and function. Their implication in multiple immune-mediated disorders highlights lncRNAs as exciting biomarkers and potential drug targets. Recent technological innovations in oligo-based therapeutics, development of RNA-targeting small molecules, and CRISPR-based approaches, position RNA as the next therapeutic frontier. Here, we review the latest advances made toward understanding the role of lncRNAs in human immunological disorders and further discuss RNA-targeting approaches that could be potentially exploited to manipulate lncRNA function as a clinical intervention.</description><identifier>ISSN: 1567-5769</identifier><identifier>EISSN: 1878-1705</identifier><identifier>DOI: 10.1016/j.intimp.2020.106279</identifier><identifier>PMID: 32058929</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Biomarkers ; Clustered Regularly Interspaced Short Palindromic Repeats ; CRISPR ; Disorders ; Drug development ; Genetic Markers ; Genetic Therapy - trends ; Humans ; Immune system ; Immunity, Cellular - genetics ; Immunology ; Immunomodulation ; Immunoregulation ; Medical innovations ; Non-coding RNA ; Regulators ; Ribonucleic acid ; RNA ; RNA, Long Noncoding - immunology ; Technological change ; Therapeutic targets</subject><ispartof>International immunopharmacology, 2020-04, Vol.81, p.106279-106279, Article 106279</ispartof><rights>2020 Elsevier B.V.</rights><rights>Copyright © 2020 Elsevier B.V. All rights reserved.</rights><rights>Copyright Elsevier BV Apr 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c491t-c26ba0752bc6667c532e4b86c43f7afa59ba2e6f69e76a928a0e1b4c71e8bfc83</citedby><cites>FETCH-LOGICAL-c491t-c26ba0752bc6667c532e4b86c43f7afa59ba2e6f69e76a928a0e1b4c71e8bfc83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.intimp.2020.106279$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32058929$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Uthaya Kumar, Dinesh Babu</creatorcontrib><creatorcontrib>Williams, Adam</creatorcontrib><title>Long non-coding RNAs in immune regulation and their potential as therapeutic targets</title><title>International immunopharmacology</title><addtitle>Int Immunopharmacol</addtitle><description>•More than 97% of transcripts in the cell are categorized as non-coding RNAs.•Long non-coding RNAs (lncRNAs) outnumber protein coding genes.•lncRNAs are often expressed in a tissue-, cell type-, and disease-specific manner.•lncRNAs play known roles in virtually all major subclasses of immune cells.•lncRNAs are implicated in multiple immunologic disorders.
Long non-coding RNAs (lncRNAs) are potent regulators of immune cell development and function. Their implication in multiple immune-mediated disorders highlights lncRNAs as exciting biomarkers and potential drug targets. Recent technological innovations in oligo-based therapeutics, development of RNA-targeting small molecules, and CRISPR-based approaches, position RNA as the next therapeutic frontier. Here, we review the latest advances made toward understanding the role of lncRNAs in human immunological disorders and further discuss RNA-targeting approaches that could be potentially exploited to manipulate lncRNA function as a clinical intervention.</description><subject>Animals</subject><subject>Biomarkers</subject><subject>Clustered Regularly Interspaced Short Palindromic Repeats</subject><subject>CRISPR</subject><subject>Disorders</subject><subject>Drug development</subject><subject>Genetic Markers</subject><subject>Genetic Therapy - trends</subject><subject>Humans</subject><subject>Immune system</subject><subject>Immunity, Cellular - genetics</subject><subject>Immunology</subject><subject>Immunomodulation</subject><subject>Immunoregulation</subject><subject>Medical innovations</subject><subject>Non-coding RNA</subject><subject>Regulators</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>RNA, Long Noncoding - immunology</subject><subject>Technological change</subject><subject>Therapeutic targets</subject><issn>1567-5769</issn><issn>1878-1705</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UcuKFTEQDaI44-gfiATcuOlrks6jsxGGYXzARUHGdUinq-_k0p20SXrAvzfNHcfHwlWKk1On6tRB6CUlO0qofHvc-VD8vOwYYRskmdKP0DntVNdQRcTjWgupGqGkPkPPcj4SUnFOn6KzlhHRaabP0c0-hgMOMTQuDr6WXz9fZuwD9vO8BsAJDutki48B2zDgcgs-4SUWqLPthG3eoGQXWIt3uNh0gJKfoyejnTK8uH8v0Lf31zdXH5v9lw-fri73jeOalsYx2VuiBOudlFI50TLgfScdb0dlRyt0bxnIUWpQ0mrWWQK0505R6PrRde0FenfSXdZ-hsHVpZKdzJL8bNMPE603f_8Ef2sO8c4oKuq9WBV4cy-Q4vcVcjGzzw6myQaIazasFUIrRdRGff0P9RjXFKo9wzgnXBNNZWXxE8ulmHOC8WEZSswWmzmaU2xmi82cYqttr_408tD0K6ffTqGe885DMtl5CA4Gn8AVM0T__wk_AcbjrDg</recordid><startdate>20200401</startdate><enddate>20200401</enddate><creator>Uthaya Kumar, Dinesh Babu</creator><creator>Williams, Adam</creator><general>Elsevier B.V</general><general>Elsevier BV</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200401</creationdate><title>Long non-coding RNAs in immune regulation and their potential as therapeutic targets</title><author>Uthaya Kumar, Dinesh Babu ; Williams, Adam</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c491t-c26ba0752bc6667c532e4b86c43f7afa59ba2e6f69e76a928a0e1b4c71e8bfc83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Biomarkers</topic><topic>Clustered Regularly Interspaced Short Palindromic Repeats</topic><topic>CRISPR</topic><topic>Disorders</topic><topic>Drug development</topic><topic>Genetic Markers</topic><topic>Genetic Therapy - trends</topic><topic>Humans</topic><topic>Immune system</topic><topic>Immunity, Cellular - genetics</topic><topic>Immunology</topic><topic>Immunomodulation</topic><topic>Immunoregulation</topic><topic>Medical innovations</topic><topic>Non-coding RNA</topic><topic>Regulators</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>RNA, Long Noncoding - immunology</topic><topic>Technological change</topic><topic>Therapeutic targets</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Uthaya Kumar, Dinesh Babu</creatorcontrib><creatorcontrib>Williams, Adam</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International immunopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Uthaya Kumar, Dinesh Babu</au><au>Williams, Adam</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long non-coding RNAs in immune regulation and their potential as therapeutic targets</atitle><jtitle>International immunopharmacology</jtitle><addtitle>Int Immunopharmacol</addtitle><date>2020-04-01</date><risdate>2020</risdate><volume>81</volume><spage>106279</spage><epage>106279</epage><pages>106279-106279</pages><artnum>106279</artnum><issn>1567-5769</issn><eissn>1878-1705</eissn><abstract>•More than 97% of transcripts in the cell are categorized as non-coding RNAs.•Long non-coding RNAs (lncRNAs) outnumber protein coding genes.•lncRNAs are often expressed in a tissue-, cell type-, and disease-specific manner.•lncRNAs play known roles in virtually all major subclasses of immune cells.•lncRNAs are implicated in multiple immunologic disorders.
Long non-coding RNAs (lncRNAs) are potent regulators of immune cell development and function. Their implication in multiple immune-mediated disorders highlights lncRNAs as exciting biomarkers and potential drug targets. Recent technological innovations in oligo-based therapeutics, development of RNA-targeting small molecules, and CRISPR-based approaches, position RNA as the next therapeutic frontier. Here, we review the latest advances made toward understanding the role of lncRNAs in human immunological disorders and further discuss RNA-targeting approaches that could be potentially exploited to manipulate lncRNA function as a clinical intervention.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>32058929</pmid><doi>10.1016/j.intimp.2020.106279</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1567-5769 |
| ispartof | International immunopharmacology, 2020-04, Vol.81, p.106279-106279, Article 106279 |
| issn | 1567-5769 1878-1705 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7150622 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Biomarkers Clustered Regularly Interspaced Short Palindromic Repeats CRISPR Disorders Drug development Genetic Markers Genetic Therapy - trends Humans Immune system Immunity, Cellular - genetics Immunology Immunomodulation Immunoregulation Medical innovations Non-coding RNA Regulators Ribonucleic acid RNA RNA, Long Noncoding - immunology Technological change Therapeutic targets |
| title | Long non-coding RNAs in immune regulation and their potential as therapeutic targets |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T02%3A22%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Long%20non-coding%20RNAs%20in%20immune%20regulation%20and%20their%20potential%20as%20therapeutic%20targets&rft.jtitle=International%20immunopharmacology&rft.au=Uthaya%20Kumar,%20Dinesh%20Babu&rft.date=2020-04-01&rft.volume=81&rft.spage=106279&rft.epage=106279&rft.pages=106279-106279&rft.artnum=106279&rft.issn=1567-5769&rft.eissn=1878-1705&rft_id=info:doi/10.1016/j.intimp.2020.106279&rft_dat=%3Cproquest_pubme%3E2355977072%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2440490916&rft_id=info:pmid/32058929&rft_els_id=S1567576919329170&rfr_iscdi=true |