Metastasis of cholangiocarcinoma is promoted by extended high-mannose glycans

Membrane-bound oligosaccharides form the interfacial boundary between the cell and its environment, mediating processes such as adhesion and signaling. These structures can undergo dynamic changes in composition and expression based on cell type, external stimuli, and genetic factors. Glycosylation,...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2020-04, Vol.117 (14), p.7633-7644
Hauptverfasser:	Park, Diane Dayoung, Phoomak, Chatchai, Xu, Gege, Olney, Laura P., Tran, Khiem A., Park, Simon S., Haigh, Nathan E., Luxardi, Guillaume, Lert-itthiporn, Worachart, Shimoda, Michiko, Li, Qiongyu, Matoba, Nobuyuki, Fierro, Fernando, Wongkham, Sopit, Maverakis, Emanual, Lebrilla, Carlito B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer Cell adhesion & migration Cell membranes Cell migration Cell surface Cholangiocarcinoma Down-regulation External stimuli Gene expression Genetic factors Glycoproteins Glycosylation Golgi apparatus Invasiveness Mannose Mannosidase Masking Membrane glycoproteins Membrane proteins Metastases Metastasis Molecular modelling N-glycans Oligosaccharides Phenotypes Physical Sciences Polysaccharides Proteins Therapeutic applications Transferrin Transferrins
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