Investigation of meropenem stability after reconstitution: the influence of buffering and challenges to meet the NHS Yellow Cover Document compliance for continuous infusions in an outpatient setting

To determine the influence of different buffers, pH and meropenem concentrations on the degradation rates of meropenem in aqueous solution during storage at 32°C, with the aim of developing a formulation suitable for 24-hour infusion in an ambulatory elastomeric device, compliant with the latest Nat...

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Veröffentlicht in:	European journal of hospital pharmacy. Science and practice 2020-03, Vol.27 (e1), p.e53-e57
Hauptverfasser:	Jamieson, Conor, Allwood, Michael Charles, Stonkute, Donata, Wallace, Andrew, Wilkinson, Alan-Shaun, Hills, Tim
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics Antimicrobial agents Aqueous solutions Caustic soda Chromatography Drug dosages Hydrochloric acid Hydrogen peroxide Infections Original Research Quality control Sodium
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